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Study · Animal study (in vivo) · rat · 1998

4 results

Antioxidant systemic effect of short-term Cerebrolysin administration.

González ME, Francis L, Castellano O

Journal of neural transmission. Supplementum1 Jan 1998Cited by 8 (Europe PMC)

PMID9700669 (opens in a new tab)DOI10.1007/978-3-7091-6467-9_29 (opens in a new tab)PepBankPUB-09700669
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats with septohippocampal lesions, Cerebrolysin lowered catalase activity relative to saline, with reported values of 19.1 and 57.3.

    In plain wordsIn rats with septohippocampal lesions, Cerebrolysin lowered catalase activity compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseSerum catalase activity in lesioned rats
    Study

    ratn: not reported in source

    Intact rats or rats with septohippocampal pathway lesion
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    Dose not stated · a weekAs given in this study (rat).

    Measurements

    CAT activity
    19.1
    SHPL-CRB
    CAT activity
    57.3
    SHPL-SAL

    Source sentences

    Summary
    Decrease of CAT levels (19.1) in the group of SHPL-CRB was higher than the values obtained (57.3) in SHPL-SAL group.
    2 context sentences
    Summary · context
    We found that Cerebrolysin induces a decrease on the CAT and SOD levels.
    Summary · context
    Levels of catalase (CAT) and superoxide dismutase (SOD) activity were determinate in serum of intact rats (INT) and those with septohippocampal pathway lesion (SHPL), which received Cerebrolysin (CRB) or saline solution (SAL) for a week.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In intact rats, the Cerebrolysin group had the lowest reported catalase activity, at 16.7.

    In plain wordsIn intact rats, the Cerebrolysin group had the lowest catalase activity among the study groups.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseSerum catalase activity in intact rats
    Study

    ratn: not reported in source

    Intact rats or rats with septohippocampal pathway lesion
    Comparator
    Other study groups
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    Dose not stated · a weekAs given in this study (rat).

    Measurements

    CAT activity
    16.7
    INT-CER

    Source sentences

    Summary
    The lowest CAT levels were detected in the INT-CER group (16.7).
    1 context sentence
    Summary · context
    Levels of catalase (CAT) and superoxide dismutase (SOD) activity were determinate in serum of intact rats (INT) and those with septohippocampal pathway lesion (SHPL), which received Cerebrolysin (CRB) or saline solution (SAL) for a week.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with septohippocampal lesions, Cerebrolysin lowered superoxide dismutase activity to 9.84 versus 14.9 with saline.

    In plain wordsIn rats with septohippocampal lesions, Cerebrolysin lowered superoxide dismutase activity compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseSerum superoxide dismutase activity in lesioned rats
    Study

    ratn: not reported in source

    Intact rats or rats with septohippocampal pathway lesion
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    Dose not stated · a weekAs given in this study (rat).

    Measurements

    SOD activity
    9.84
    SHPL-CER
    SOD activity
    14.9
    SHPL-SAL

    Source sentences

    Summary
    The SOD levels obtained in SHPL-CER group (9.84) were also smaller than those obtained in the SHPL-SAL group (14.9) which showed the highest levels of SOD, while the INT animals showed the lowest levels (7.6).
    1 context sentence
    Summary · context
    Levels of catalase (CAT) and superoxide dismutase (SOD) activity were determinate in serum of intact rats (INT) and those with septohippocampal pathway lesion (SHPL), which received Cerebrolysin (CRB) or saline solution (SAL) for a week.
  4. 04AnimalAnimal study (in vivo)Safety outcome

    In rats with septohippocampal lesions, mortality was 18% with Cerebrolysin versus 43% with saline.

    In plain wordsIn rats with septohippocampal lesions, mortality was lower with Cerebrolysin than saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseMortality in lesioned rats
    Study

    ratn: not reported in source

    Intact rats or rats with septohippocampal pathway lesion
    Comparator
    Saline
    Outcome group
    Mortality · Whole body
    Studied dose
    Dose not stated · a weekAs given in this study (rat).

    Measurements

    Mortality
    18%
    CER
    Mortality
    43%
    SAL

    Source sentences

    Summary
    In addition, the SHPL animals mortality was of 18% for the CER group against 43% for SAL group.
    1 context sentence
    Summary · context
    Levels of catalase (CAT) and superoxide dismutase (SOD) activity were determinate in serum of intact rats (INT) and those with septohippocampal pathway lesion (SHPL), which received Cerebrolysin (CRB) or saline solution (SAL) for a week.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

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