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Study · In vitro (cells) · 1998

3 results

Molecular regulation of the blood-brain barrier GLUT1 glucose transporter by brain-derived factors.

Boado RJ

Journal of neural transmission. Supplementum1 Jan 1998Cited by 7 (Europe PMC)

PMID9700668 (opens in a new tab)DOI10.1007/978-3-7091-6467-9_28 (opens in a new tab)PepBankPUB-09700668
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In brain endothelial cells, Cerebrolysin increased expression of the BBB-GLUT1 clone 753 reporter containing a transcript-stabilizing regulatory element.

    In plain wordsIn cells, Cerebrolysin increased glucose transporter reporter expression when a stabilizing regulatory element was present.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseBBB-GLUT1 clone 753 reporter expression
    Study

    n: not reported in source

    Brain endothelial cultured cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the present investigation, Cl markedly increased (p < 0.001) the expression of a BBB-GLUT1 reporter gene, named clone 753, that contains an important regulatory cis-acting element involved in the stabilization of this transcript in brain endothelial cultured cells (ECL).
  2. 02LabIn vitro (cells)Mechanism

    In brain endothelial cells, Cerebrolysin produced only a minimal reporter response without the regulatory element compared with clone 753.

    In plain wordsIn cells, Cerebrolysin produced a smaller reporter response without the regulatory element than with it.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseReporter response without regulatory element
    Study

    n: not reported in source

    Brain endothelial cultured cells
    Comparator
    Clone 753 reporter with regulatory element
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In experiments with a reporter gene lacking this regulatory element, Cl produced only a minimal fraction of the effect observed with clone 753.
  3. 03LabIn vitro (cells)Mechanism

    In brain endothelial cells, Cerebrolysin increased the abundance of the GLUT1 RNA-protein cis/trans acting complex.

    In plain wordsIn cells, Cerebrolysin increased a complex formed by glucose transporter RNA and cell proteins.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseCis/trans acting complex abundance
    Study

    n: not reported in source

    Brain endothelial cultured cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The abundance of this cis/trans acting complex was found to be increased in Cl-treated cells.
    1 context sentence
    Summary · context
    UV-cross linking/PAGE experiments showed that the GLUT1 transcript reacts with ECL cytosolic proteins to form a RNA/protein complex of approximately 80 kDa.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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