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Study · Animal study (in vivo) · rat · 1998

6 results

The influence of Cerebrolysin and E021 on spatial navigation of 24-month-old rats.

Gschanes A, Windisch M

Journal of neural transmission. Supplementum1 Jan 1998Cited by 15 (Europe PMC)

PMID9700667 (opens in a new tab)DOI10.1007/978-3-7091-6467-9_27 (opens in a new tab)PepBankPUB-09700667
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In aged rats, Cerebrolysin reduced escape latency versus saline on all four test days.

    In plain wordsIn aged rats, Cerebrolysin reduced maze escape time compared with saline on all test days.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseEscape latency
    Study

    ratn: not reported in source

    24-month-old rats in Morris water maze
    Comparator
    Saline
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    2.5 ml/kg · intraperitoneal · 19 daysAs given in this study (rat).

    Source sentences

    Summary
    Both Cere and E021 treated rats showed significant lower escape latencies than saline treated controls on all four test days (p < 0.01).
    3 context sentences
    Summary · context
    In the present study the behavioural effects of Cerebrolysin (Cere), a peptidergic nootropic drug, and E021, the concentrated peptide fraction of Cere, were investigated in 24-month-old rats.
    Summary · context
    Rats passing a pretest to exclude motor- and eye-deficits were treated with either drugs or saline as control (2.5 ml/kg, intraperitoneally i.p.) for 19 days.
    Summary · context
    Animals were tested in a standard Morris water maze on day 16 after pretest for 4 consecutive days (test days 1-4), eight trials per day.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In aged rats, Cerebrolysin effects on spatial navigation were more pronounced in females than males.

    In plain wordsIn aged rats, Cerebrolysin had stronger spatial navigation effects in females than males.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseFemale spatial navigation treatment effect
    Study

    ratn: not reported in source

    24-month-old rats in Morris water maze
    Comparator
    Male rats
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    2.5 ml/kg · intraperitoneal · 19 daysAs given in this study (rat).

    Source sentences

    Summary
    More pronounced effects of both drugs were found for female rats.
    4 context sentences
    Summary · context
    Both Cere and E021 treated rats showed significant lower escape latencies than saline treated controls on all four test days (p < 0.01).
    Summary · context
    In the present study the behavioural effects of Cerebrolysin (Cere), a peptidergic nootropic drug, and E021, the concentrated peptide fraction of Cere, were investigated in 24-month-old rats.
    Summary · context
    Rats passing a pretest to exclude motor- and eye-deficits were treated with either drugs or saline as control (2.5 ml/kg, intraperitoneally i.p.) for 19 days.
    Summary · context
    Animals were tested in a standard Morris water maze on day 16 after pretest for 4 consecutive days (test days 1-4), eight trials per day.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In aged female rats, the Cerebrolysin study found no significant differences in motor activity.

    In plain wordsIn aged female rats, motor activity did not differ significantly between Cerebrolysin and saline groups.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeFemale motor activity
    Study

    ratn: not reported in source

    24-month-old rats in Morris water maze
    Comparator
    Saline
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    2.5 ml/kg · intraperitoneal · 19 daysAs given in this study (rat).

    Source sentences

    Summary
    Female rats showed no significant differences in motor activity whereas drug treated males swam quicker on test day 1 (Cere p < 0.01: E021 p < 0.05) and day 2 (Cere p < 0.01).
    3 context sentences
    Summary · context
    In the present study the behavioural effects of Cerebrolysin (Cere), a peptidergic nootropic drug, and E021, the concentrated peptide fraction of Cere, were investigated in 24-month-old rats.
    Summary · context
    Rats passing a pretest to exclude motor- and eye-deficits were treated with either drugs or saline as control (2.5 ml/kg, intraperitoneally i.p.) for 19 days.
    Summary · context
    Animals were tested in a standard Morris water maze on day 16 after pretest for 4 consecutive days (test days 1-4), eight trials per day.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In aged male rats, Cerebrolysin increased swimming speed versus saline on test day 1.

    In plain wordsIn aged male rats, Cerebrolysin increased swimming speed compared with saline on the first test day.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseMale swimming speed on test day 1
    Study

    ratn: not reported in source

    24-month-old rats in Morris water maze
    Comparator
    Saline
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    2.5 ml/kg · intraperitoneal · 19 daysAs given in this study (rat).

    Source sentences

    Summary
    Female rats showed no significant differences in motor activity whereas drug treated males swam quicker on test day 1 (Cere p < 0.01: E021 p < 0.05) and day 2 (Cere p < 0.01).
    3 context sentences
    Summary · context
    In the present study the behavioural effects of Cerebrolysin (Cere), a peptidergic nootropic drug, and E021, the concentrated peptide fraction of Cere, were investigated in 24-month-old rats.
    Summary · context
    Rats passing a pretest to exclude motor- and eye-deficits were treated with either drugs or saline as control (2.5 ml/kg, intraperitoneally i.p.) for 19 days.
    Summary · context
    Animals were tested in a standard Morris water maze on day 16 after pretest for 4 consecutive days (test days 1-4), eight trials per day.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In aged male rats, Cerebrolysin increased swimming speed versus saline on test day 2.

    In plain wordsIn aged male rats, Cerebrolysin increased swimming speed compared with saline on the second test day.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseMale swimming speed on test day 2
    Study

    ratn: not reported in source

    24-month-old rats in Morris water maze
    Comparator
    Saline
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    2.5 ml/kg · intraperitoneal · 19 daysAs given in this study (rat).

    Source sentences

    Summary
    Female rats showed no significant differences in motor activity whereas drug treated males swam quicker on test day 1 (Cere p < 0.01: E021 p < 0.05) and day 2 (Cere p < 0.01).
    3 context sentences
    Summary · context
    In the present study the behavioural effects of Cerebrolysin (Cere), a peptidergic nootropic drug, and E021, the concentrated peptide fraction of Cere, were investigated in 24-month-old rats.
    Summary · context
    Rats passing a pretest to exclude motor- and eye-deficits were treated with either drugs or saline as control (2.5 ml/kg, intraperitoneally i.p.) for 19 days.
    Summary · context
    Animals were tested in a standard Morris water maze on day 16 after pretest for 4 consecutive days (test days 1-4), eight trials per day.

Studies that did not test the peptide alone1

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

  1. 06AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome

    In aged rats, escape latency showed no significant difference between males and females before results were pooled.

    In plain wordsIn aged rats in the Cerebrolysin study, escape time did not differ significantly between males and females.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeSex difference in escape latency
    Study

    ratn: not reported in source

    24-month-old rats in Morris water maze
    Comparator
    Male versus female rats
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    No significant differences of escape latency between males and females were found, therefore, results were pooled.
    3 context sentences
    Summary · context
    In the present study the behavioural effects of Cerebrolysin (Cere), a peptidergic nootropic drug, and E021, the concentrated peptide fraction of Cere, were investigated in 24-month-old rats.
    Summary · context
    Rats passing a pretest to exclude motor- and eye-deficits were treated with either drugs or saline as control (2.5 ml/kg, intraperitoneally i.p.) for 19 days.
    Summary · context
    Animals were tested in a standard Morris water maze on day 16 after pretest for 4 consecutive days (test days 1-4), eight trials per day.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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