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Study · Animal study (in vivo) · rat · 1998

3 results

[The effect of the new nootropic dipeptide GVS-111 in different functional disorders of the escape reaction].

Inozemtsev AN, Trofimov SS, Borlikova GG, Firova FA, Pragina LL, Gudasheva TA, Ostrovskaia RU, Tushmalova NA, Voronina TA

Eksperimental'naia i klinicheskaia farmakologiia1 May 1998

PMID9690067 (opens in a new tab)PepBankPUB-09690067
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, GVS-111 improved avoidance learning, but the effect varied between experiments.

    In plain wordsIn rats, GVS-111 improved avoidance learning, but the effect varied between experiments.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseLearning
    Study

    ratn: not reported in source

    Avoidance reaction functional disorders
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    0.1 mg/kg/day · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Intraperitoneal injection of GVS-111 (0.1 mg/kg/day) improved the learning, but the effect differed from experiment to experiment.
    1 context sentence
    Summary · context
    The authors studied the effect of a new nootropic agent with anxiolytic properties GVS-111 (ethyl ether N-phenylacetyl-L-prolylglycine) on formation of the avoidance reaction (AR) in rats and its functional disorders which were induced by two methods.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, GVS-111 prevented avoidance reaction disturbance during an error.

    In plain wordsIn rats, GVS-111 prevented avoidance response disturbance during an error.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseAvoidance reaction disturbance during error
    Study

    ratn: not reported in source

    Avoidance reaction functional disorders
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    0.1 mg/kg/day · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Along with this, the dipeptide prevented AR disturbance during the error and quickened restoration of the habit in spatial remodeling.
    1 context sentence
    Summary · context
    The authors studied the effect of a new nootropic agent with anxiolytic properties GVS-111 (ethyl ether N-phenylacetyl-L-prolylglycine) on formation of the avoidance reaction (AR) in rats and its functional disorders which were induced by two methods.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, GVS-111 accelerated habit restoration during spatial remodeling.

    In plain wordsIn rats, GVS-111 accelerated habit restoration when the escape opening changed.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseHabit restoration during spatial remodeling
    Study

    ratn: not reported in source

    Avoidance reaction functional disorders
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    0.1 mg/kg/day · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Along with this, the dipeptide prevented AR disturbance during the error and quickened restoration of the habit in spatial remodeling.
    2 context sentences
    Summary · context
    In another case the spatial stereotype of the experiment was altered by changing the place of the opening through which the animal avoided the stimulus (spatial remodeling).
    Summary · context
    The authors studied the effect of a new nootropic agent with anxiolytic properties GVS-111 (ethyl ether N-phenylacetyl-L-prolylglycine) on formation of the avoidance reaction (AR) in rats and its functional disorders which were induced by two methods.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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