Effects of growth hormone secretagogues on prolactin release in anesthetized dwarf (dw/dw) rats.

Carmignac DF, Bennett PA, Robinson IC

Endocrinology1 Aug 1998Cited by 15 (Europe PMC)

PMID9681512DOI10.1210/endo.139.8.6148PepBankPUB-09681512

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Activity measurement
In normal male rats, GHRP‑6 did not induce prolactin release.
In plain wordsIn rats, GHRP‑6 did not induce prolactin release in normal males.
Peptide
GHRP-6
Outcome
No significant changeProlactin release in normal males
Study
ratn: not reported in source
Normal male rats
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
0.1-2.5 microg · intravenousAs given in this study (rat).
Source sentences
Summary
Whereas GHRP-6 (0.1-2.5 microg, i.v.) did not induce PRL release in normal male or female rats, significant PRL responses were observed in dw/dw females.
Report a problemFND-0968151201
02AnimalAnimal study (in vivo)Activity measurement
In normal female rats, GHRP‑6 did not induce prolactin release.
In plain wordsIn rats, GHRP‑6 did not induce prolactin release in normal females.
Peptide
GHRP-6
Outcome
No significant changeProlactin release in normal females
Study
ratn: not reported in source
Normal female rats
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
0.1-2.5 microg · intravenousAs given in this study (rat).
Source sentences
Summary
Whereas GHRP-6 (0.1-2.5 microg, i.v.) did not induce PRL release in normal male or female rats, significant PRL responses were observed in dw/dw females.
Report a problemFND-0968151202
03AnimalAnimal study (in vivo)Activity measurement
In dw/dw female rats, GHRP‑6 induced significant prolactin responses.
In plain wordsIn dwarf female rats, GHRP‑6 increased prolactin release.
Peptide
GHRP-6
Outcome
IncreaseProlactin release in dwarf females
Study
ratn: not reported in source
GH-deficient female dw/dw rats
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
0.1-2.5 microg · intravenousAs given in this study (rat).
Source sentences
Summary
Whereas GHRP-6 (0.1-2.5 microg, i.v.) did not induce PRL release in normal male or female rats, significant PRL responses were observed in dw/dw females.
Report a problemFND-0968151203
04AnimalAnimal study (in vivo)Activity measurement
In rats, GHRP‑6 did not affect TSH levels.
In plain wordsIn rats, GHRP‑6 did not change TSH levels.
Peptide
GHRP-6
Outcome
No significant changeTSH levels
Study
ratn: not reported in source
Normal and GH-deficient dw/dw rats
Outcome group
Thyroid function · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
However, the effects of GHRP-6 on PRL were unlikely to be mediated by TRH because in the same animals, TSH levels were unaffected by GHRP-6 whereas they were increased by TRH.
Report a problemFND-0968151206

Studies that did not test the peptide alone2

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

05AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism
In dw/dw female rats, ovariectomy abolished GHRP‑6-induced prolactin responses.
In plain wordsIn dwarf female rats, ovary removal abolished the prolactin response to GHRP‑6.
Peptide
GHRP-6
Outcome
DecreaseOvariectomy and prolactin response
Study
ratn: not reported in source
GH-deficient female dw/dw rats
Outcome group
Pituitary hormones · Endocrine and hormones
Source sentences
Summary
These responses were abolished by ovariectomy and could be strongly induced in male dw/dw rats by E2 treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Whereas GHRP-6 (0.1-2.5 microg, i.v.) did not induce PRL release in normal male or female rats, significant PRL responses were observed in dw/dw females.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0968151204
06AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism
In male dw/dw rats, estrogen treatment strongly induced prolactin responses to GHRP‑6.
In plain wordsIn dwarf male rats, estrogen treatment strongly induced the prolactin response to GHRP‑6.
Peptide
GHRP-6
Outcome
IncreaseEstrogen and prolactin response
Study
ratn: not reported in source
GH-deficient male dw/dw rats
Outcome group
Pituitary hormones · Endocrine and hormones
Source sentences
Summary
These responses were abolished by ovariectomy and could be strongly induced in male dw/dw rats by E2 treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Whereas GHRP-6 (0.1-2.5 microg, i.v.) did not induce PRL release in normal male or female rats, significant PRL responses were observed in dw/dw females.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0968151205

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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