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Study · Not a test of the peptide alone · 1998

3 results

Preserved growth hormone (GH) secretion in aged and very old subjects after testing with the combined stimulus GH-releasing hormone plus GH-releasing hexapeptide-6.

Micic D, Popovic V, Doknic M, Macut D, Dieguez C, Casanueva FF

The Journal of clinical endocrinology and metabolism1 Jul 1998Cited by 21 (Europe PMC)

PMID9661645 (opens in a new tab)DOI10.1210/jcem.83.7.4957 (opens in a new tab)PepBankPUB-09661645
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 01HumanNot a test of GHRP-6 aloneNon-randomized trialEfficacy outcome

    In normal subjects, the GH area under the curve after combined GHRH plus GHRP‑6 did not differ between adults, aged and very old subjects.

    In plain wordsIn healthy people, GHRP‑6 with GHRH gave a similar total growth hormone release in younger, older and very old people.

    Peptide
    GHRP-6
    Outcome
    No significant changeGH area under the curve after GHRH plus GHRP-6 across age groups
    Study

    n = 26

    Comparator
    Adults aged 19-40 years
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    In the three groups, the combined administration of GHRH plus GHRP-6 elicited a GH area under the curve (microgram/L per 120 min) of 3,127 +/- 262, 3,409 +/- 573, and 4,655 +/- 737 for adults, aged, and very old subjects, respectively (nonsignificant differences).
    2 context sentences
    Summary · context
    To understand whether the GH discharge elicited by the combined stimulus declines with age, 26 normal subjects of both sexes, divided into 3 age groups [adults 19-40 yr; aged 46-65 yr; and very old (75-96 yr) subjects] were studied.
    Summary · context
    They were administered i.v., as bolus and in combination, 90 micrograms GHRH plus 90 micrograms GHRP-6.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 02HumanNot a test of GHRP-6 aloneNon-randomized trialEfficacy outcome

    In normal subjects, the peak GH after combined GHRH plus GHRP‑6 did not differ between adults, aged and very old subjects.

    In plain wordsIn healthy people, GHRP‑6 with GHRH gave a similar growth hormone peak in younger, older and very old people.

    Peptide
    GHRP-6
    Outcome
    No significant changePeak GH after GHRH plus GHRP-6 across age groups
    Study

    n = 26

    Comparator
    Adults aged 19-40 years
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    The mean GH peak was 47.5 +/- 4.5 micrograms/L for adults, 52.9 +/- 8.4 micrograms/L for aged subjects, and 76.0 +/- 11.7 for very old subjects (nonsignificant differences).
    2 context sentences
    Summary · context
    To understand whether the GH discharge elicited by the combined stimulus declines with age, 26 normal subjects of both sexes, divided into 3 age groups [adults 19-40 yr; aged 46-65 yr; and very old (75-96 yr) subjects] were studied.
    Summary · context
    They were administered i.v., as bolus and in combination, 90 micrograms GHRH plus 90 micrograms GHRP-6.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  3. 03HumanNot a test of GHRP-6 aloneNon-randomized trialEfficacy outcome

    In normal subjects of all ages, there were no nonresponders to combined GHRH plus GHRP‑6 and every subject had a GH peak over 25 micrograms/L.

    In plain wordsIn healthy people of all ages, everyone responded to GHRP‑6 with GHRH with a clear growth hormone rise.

    Peptide
    GHRP-6
    Outcome
    Not applicableGH responders to GHRH plus GHRP-6
    Study

    n = 26

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Individually examined, there were no nonresponders to the combined stimulus, and all subjects (independently of age) showed a GH peak over 25 micrograms/L (the lowest peak was 27.3 micrograms/L, and the highest peak was 119.2 micrograms/L).
    2 context sentences
    Summary · context
    To understand whether the GH discharge elicited by the combined stimulus declines with age, 26 normal subjects of both sexes, divided into 3 age groups [adults 19-40 yr; aged 46-65 yr; and very old (75-96 yr) subjects] were studied.
    Summary · context
    They were administered i.v., as bolus and in combination, 90 micrograms GHRH plus 90 micrograms GHRP-6.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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