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Study · Measured the body's own peptide · 1998

3 results

Melatonin inhibits oxytocin response to insulin-induced hypoglycemia, but not to angiotensin II in normal men.

Chiodera P, Volpi R, Capretti L, Giuliani N, Caffarri G, Coiro V

Journal of neural transmission (Vienna, Austria : 1996)1 Jan 1998Cited by 5 (Europe PMC)

PMID9660095 (opens in a new tab)DOI10.1007/s007020050046 (opens in a new tab)PepBankPUB-09660095
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelNon-randomized trialOther

    In normal men, oral melatonin (6 or 12 mg) did not change basal levels of the body's own oxytocin.

    In plain wordsIn healthy men, melatonin did not change the body's own basal oxytocin levels.

    Peptide
    Oxytocin
    Outcome
    No significant changeBasal oxytocin secretion after melatonin
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    The administration of 6 or 12 mg melatonin did not change basal and angiotensin II-stimulated oxytocin secretion.
    1 context sentence
    Summary · context
    In order to establish whether melatonin alters basal and/or stimulated oxytocin secretion, 18 normal men were treated (p.o.) with 6 or 12 mg melatonin or placebo in basal conditions (N-6 subjects) or concomitantly to the administration of insulin (O.15 IU/kg body weight in an i.v. bolus) (N-6 subjec…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelNon-randomized trialOther

    In normal men, oral melatonin (6 or 12 mg) did not change angiotensin II-stimulated secretion of the body's own oxytocin.

    In plain wordsIn healthy men, melatonin did not change the rise in the body's own oxytocin caused by angiotensin II.

    Peptide
    Oxytocin
    Outcome
    No significant changeAngiotensin II-stimulated oxytocin secretion after melatonin
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    The administration of 6 or 12 mg melatonin did not change basal and angiotensin II-stimulated oxytocin secretion.
    1 context sentence
    Summary · context
    In order to establish whether melatonin alters basal and/or stimulated oxytocin secretion, 18 normal men were treated (p.o.) with 6 or 12 mg melatonin or placebo in basal conditions (N-6 subjects) or concomitantly to the administration of insulin (O.15 IU/kg body weight in an i.v. bolus) (N-6 subjec…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelNon-randomized trialOther

    In normal men, oral melatonin significantly reduced the response of the body's own oxytocin to insulin-induced hypoglycaemia (peak 1.6 times baseline versus 2.2 times without melatonin).

    In plain wordsIn healthy men, melatonin lowered the rise in the body's own oxytocin after low blood sugar compared with no melatonin.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin response to insulin-induced hypoglycaemia after melatonin
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Measurements

    Peak oxytocin response to hypoglycaemia
    2.2 times baseline
    without melatonin
    Peak oxytocin response to hypoglycaemia
    1.6 times baseline
    melatonin 6 or 12 mg

    Source sentences

    Summary
    In contrast, the oxytocin response to insulin-induced hypoglycemia was significantly reduced by melatonin treatment.
    2 context sentences
    Summary · context
    In fact, the mean peak oxytocin response to hypoglycemia was 2.2 times higher than baseline in the absence of melatonin, whereas it was 1.6 times higher than basal value after administration of 6 or 12 mg melatonin.
    Summary · context
    In order to establish whether melatonin alters basal and/or stimulated oxytocin secretion, 18 normal men were treated (p.o.) with 6 or 12 mg melatonin or placebo in basal conditions (N-6 subjects) or concomitantly to the administration of insulin (O.15 IU/kg body weight in an i.v. bolus) (N-6 subjec…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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