[Effect of the nootropic agent cerebrolysin in cerebral ischemia in rats with varying behavioral reactions in the open field test].

Gannushkina IV, Antelava AL, Baranchikova MV

Patologicheskaia fiziologiia i eksperimental'naia terapiia1 Apr 1998

PMID9633187PepBankPUB-09633187

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In intact rats, Cerebrolysin enhanced EEG activity.
In plain wordsIn intact rats, Cerebrolysin increased electrical brain activity.
Peptide
Cerebrolysin
Outcome
IncreaseEEG activity in intact rats
Study
ratn: not reported in source
White male rats with intact circulation or acute carotid-occlusion brain ischemia
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
0.3 ml/100 g body mass · intraperitonealAs given in this study (rat).
Source sentences
Summary
It was confirmed that cerebrolysin, as an active nootrop, enhances EEG. This effect takes place both in intact and brain ischemia rats.
2 context sentences(design, population, supporting numbers)
Summary · context
Cerebrolysin was injected i.p. in a dose 0.3 ml/100 g body mass.
Summary · context
Brain ischemia was provoked by occlusion of the common carotid arteries.
Report a problemFND-0963318701
02AnimalAnimal study (in vivo)Mechanism
In rats with brain ischemia, Cerebrolysin enhanced EEG activity.
In plain wordsIn rats with brain ischemia, Cerebrolysin increased electrical brain activity.
Peptide
Cerebrolysin
Outcome
IncreaseEEG activity in ischemic rats
Study
ratn: not reported in source
White male rats with intact circulation or acute carotid-occlusion brain ischemia
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
0.3 ml/100 g body mass · intraperitonealAs given in this study (rat).
Source sentences
Summary
It was confirmed that cerebrolysin, as an active nootrop, enhances EEG. This effect takes place both in intact and brain ischemia rats.
2 context sentences(design, population, supporting numbers)
Summary · context
Cerebrolysin was injected i.p. in a dose 0.3 ml/100 g body mass.
Summary · context
Brain ischemia was provoked by occlusion of the common carotid arteries.
Report a problemFND-0963318702
03AnimalAnimal study (in vivo)Mechanism
In rats, Cerebrolysin effectiveness varied with baseline behavior in the open field test.
In plain wordsIn rats, Cerebrolysin effects varied with behavior in an open field test.
Peptide
Cerebrolysin
Outcome
Direction not reportedBehavior-dependent effectiveness
Study
ratn: not reported in source
White male rats with intact circulation or acute carotid-occlusion brain ischemia
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
0.3 ml/100 g body mass · intraperitonealAs given in this study (rat).
Source sentences
Summary
It was also found that cerebrolysin has different effectiveness dependent on the animal's behavior in the open field test, that blood supply to the brain does not increase in cerebrolysin-activated HNA.
2 context sentences(design, population, supporting numbers)
Summary · context
Cerebrolysin was injected i.p. in a dose 0.3 ml/100 g body mass.
Summary · context
Brain ischemia was provoked by occlusion of the common carotid arteries.
Report a problemFND-0963318703
04AnimalAnimal study (in vivo)Mechanism
In rats, cerebral blood supply did not increase during Cerebrolysin-activated higher nervous activity.
In plain wordsIn rats, Cerebrolysin increased nervous activity without an increase in brain blood supply.
Peptide
Cerebrolysin
Outcome
Direction not reportedCerebral blood supply during activated nervous activity
Study
ratn: not reported in source
White male rats with intact circulation or acute carotid-occlusion brain ischemia
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
0.3 ml/100 g body mass · intraperitonealAs given in this study (rat).
Source sentences
Summary
It was also found that cerebrolysin has different effectiveness dependent on the animal's behavior in the open field test, that blood supply to the brain does not increase in cerebrolysin-activated HNA.
2 context sentences(design, population, supporting numbers)
Summary · context
Cerebrolysin was injected i.p. in a dose 0.3 ml/100 g body mass.
Summary · context
Brain ischemia was provoked by occlusion of the common carotid arteries.
Report a problemFND-0963318704
05AnimalAnimal study (in vivo)Mechanism
In rats with intensive EEG activation, Cerebrolysin reduced cerebral blood supply.
In plain wordsIn rats with strong electrical brain activation, Cerebrolysin reduced brain blood supply.
Peptide
Cerebrolysin
Outcome
DecreaseCerebral blood supply during intensive EEG activation
Study
ratn: not reported in source
White male rats with intact circulation or acute carotid-occlusion brain ischemia
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
0.3 ml/100 g body mass · intraperitonealAs given in this study (rat).
Source sentences
Summary
In stable circulation, this was compensated due to cerebral metabolic reserve, but in intensive EEG activation, recorded by CC/EEG index, cerebrolysin reduces cerebral blood supply aggravating acute brain ischemia.
2 context sentences(design, population, supporting numbers)
Summary · context
Cerebrolysin was injected i.p. in a dose 0.3 ml/100 g body mass.
Summary · context
Brain ischemia was provoked by occlusion of the common carotid arteries.
Report a problemFND-0963318705
06AnimalAnimal study (in vivo)Safety outcome
In rats with intensive EEG activation, Cerebrolysin aggravated acute brain ischemia as cerebral blood supply decreased.
In plain wordsIn rats with strong electrical brain activation, Cerebrolysin worsened acute brain ischemia.
Peptide
Cerebrolysin
Outcome
IncreaseAcute brain ischemia aggravation
Study
ratn: not reported in source
White male rats with intact circulation or acute carotid-occlusion brain ischemia
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
0.3 ml/100 g body mass · intraperitonealAs given in this study (rat).
Source sentences
Summary
In stable circulation, this was compensated due to cerebral metabolic reserve, but in intensive EEG activation, recorded by CC/EEG index, cerebrolysin reduces cerebral blood supply aggravating acute brain ischemia.
2 context sentences(design, population, supporting numbers)
Summary · context
Cerebrolysin was injected i.p. in a dose 0.3 ml/100 g body mass.
Summary · context
Brain ischemia was provoked by occlusion of the common carotid arteries.
Report a problemFND-0963318706

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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