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Study · Animal study (in vivo) · goat · 1998

3 results

Intrahypothalamic perfusion of KP102 stimulates growth hormone release in goats.

Hashizume T, Sasaki K, Kobayashi S, Nitta Y

Endocrine journal1 Feb 1998Cited by 6 (Europe PMC)

PMID9625446 (opens in a new tab)DOI10.1507/endocrj.45.53 (opens in a new tab)PepBankPUB-09625446
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In female goats, intrahypothalamic perfusion of KP102 (GHRP‑2) significantly increased plasma GH, with higher values than in control animals from 165 to 240 min after perfusion began.

    In plain wordsIn female goats, GHRP‑2 placed into the hypothalamus raised growth hormone in the blood compared with control animals.

    Peptide
    GHRP-2
    Outcome
    IncreasePlasma GH release
    Study

    goatn: not reported in source

    Female goats
    Comparator
    Control animals
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10(-5) M · intrahypothalamic perfusion by microdialysis probe · 90 minAs given in this study (goat).

    Source sentences

    Summary
    The intrahypothalamic perfusion of 10(-5) M KP102 significantly stimulated GH release in goats (P<0.05).
    2 context sentences
    Summary · context
    The concentrations of GH at 165, 180, 195, 210, 225 and 240 min after commencement of perfusion of KP102 were significantly higher than the corresponding values for control animals (P<0.05).
    Summary · context
    KP102 (10(-5) M) was perfused into the goat hypothalamus through a microdialysis probe (CMA/10 probe with a 4 mm membrane length) at a rate of 4 microl/min for 90 min, and plasma GH concentrations before and after perfusion were measured.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In female goats, KP102 significantly increased GH pulse amplitude after the perfusion.

    In plain wordsIn female goats, GHRP‑2 placed into the hypothalamus made growth hormone pulses larger.

    Peptide
    GHRP-2
    Outcome
    IncreaseGH pulse amplitude
    Study

    goatn: not reported in source

    Female goats
    Comparator
    Control animals
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10(-5) M · intrahypothalamic perfusion by microdialysis probe · 90 minAs given in this study (goat).

    Source sentences

    Summary
    it significantly increased the GH pulse amplitude after the perfusion (P<0.05).
    1 context sentence
    Summary · context
    KP102 (10(-5) M) was perfused into the goat hypothalamus through a microdialysis probe (CMA/10 probe with a 4 mm membrane length) at a rate of 4 microl/min for 90 min, and plasma GH concentrations before and after perfusion were measured.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In female goats, KP102 had no effect on GH pulse frequency.

    In plain wordsIn female goats, GHRP‑2 placed into the hypothalamus did not change how often growth hormone pulses occurred.

    Peptide
    GHRP-2
    Outcome
    No significant changeGH pulse frequency
    Study

    goatn: not reported in source

    Female goats
    Comparator
    Control animals
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10(-5) M · intrahypothalamic perfusion by microdialysis probe · 90 minAs given in this study (goat).

    Source sentences

    Summary
    KP102 had no effect on GH pulse frequency
    1 context sentence
    Summary · context
    KP102 (10(-5) M) was perfused into the goat hypothalamus through a microdialysis probe (CMA/10 probe with a 4 mm membrane length) at a rate of 4 microl/min for 90 min, and plasma GH concentrations before and after perfusion were measured.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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