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Study · In vitro (cells) · 1998

1 result

Effect of follicle stimulating hormone and insulin-like growth factors on proteolysis of insulin-like growth factor binding protein-4 in human granulosa cells.

Iwashita M, Kudo Y, Takeda Y

Molecular human reproduction1 Apr 1998Cited by 19 (Europe PMC)

PMID9620841 (opens in a new tab)DOI10.1093/molehr/4.4.401 (opens in a new tab)PepBankPUB-09620841
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In human granulosa cell cultures, LR3-IGF-I did not stimulate IGFBP-4 degradation.

    In plain wordsIn human ovary cells in a dish, LR3-IGF-I did not trigger breakdown of IGFBP-4.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeIGFBP-4 proteolysis
    Study

    humann: not reported in source

    human granulosa cell culture
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The degradation of IGFBP-4 was not stimulated when cells were incubated with the IGF-I analogue, LR3-IGF-I, and insulin which binds to IGF-I receptor but has little or no affinity for IGFBPs.
    1 context sentence
    Summary · context
    The effect of follicle stimulating hormone (FSH) and insulin-like growth factors (IGFs) on IGFBP-4 proteolytic activity was studied using granulosa cell cultures.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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