Cognitive changes during growth hormone replacement in adult men.

Deijen JB, de Boer H, van der Veen EA

Psychoneuroendocrinology1 Jan 1998Cited by 132 (Europe PMC)

PMID9618751DOI10.1016/s0306-4530(97)00092-9PepBankPUB-09618751

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

01HumanNon-randomized trialEfficacy outcome
In adult men with childhood-onset GH deficiency, memory improved at 6 months with supraphysiological GH treatment.
In plain wordsIn men with childhood-onset GH deficiency, memory improved after 6 months of supraphysiological GH treatment.
Peptide
HGH (somatotropin)
Outcome
IncreaseMemory with supraphysiological GH at 6 months
Study
n: not reported in source
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · 6 monthsAs given in this study (human).
Source sentences
Summary
At 6 months memory only had improved in the group receiving supraphysiological GH treatment, but not in the group of patients who had a normalization of serum IGF-I.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study evaluates the effects of 2 years of growth hormone (GH) replacement therapy on psychological well-being and cognitive performance in adults with childhood-onset growth hormone deficiency (CO-GHD).
Summary · context
A total of 48 GHD adult men (mean age: 27 years) were randomly assigned to one of four treatment groups: placebo treatment, or GH replacement in a dose of 1, 2, or 3 IU/m2, respectively.
Summary · context
Placebo treatment was given for 6 months.
Report a problemFND-0961875103
02HumanNon-randomized trialEfficacy outcome
In adult men with childhood-onset GH deficiency, memory did not improve at 6 months when GH normalized serum IGF-I.
In plain wordsIn men with childhood-onset GH deficiency, memory did not improve after 6 months of GH that normalized blood IGF-I.
Peptide
HGH (somatotropin)
Outcome
No significant changeMemory with physiological GH at 6 months
Study
n: not reported in source
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · 6 monthsAs given in this study (human).
Source sentences
Summary
At 6 months memory only had improved in the group receiving supraphysiological GH treatment, but not in the group of patients who had a normalization of serum IGF-I.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study evaluates the effects of 2 years of growth hormone (GH) replacement therapy on psychological well-being and cognitive performance in adults with childhood-onset growth hormone deficiency (CO-GHD).
Summary · context
A total of 48 GHD adult men (mean age: 27 years) were randomly assigned to one of four treatment groups: placebo treatment, or GH replacement in a dose of 1, 2, or 3 IU/m2, respectively.
Summary · context
Placebo treatment was given for 6 months.
Report a problemFND-0961875104
03HumanNon-randomized trialEfficacy outcome
In adult men with childhood-onset GH deficiency, physiological GH normalized memory after 1 year and maintained normalization during the 2nd year.
In plain wordsIn men with childhood-onset GH deficiency, physiological GH normalized memory after 1 year, with normalization maintained during the 2nd year.
Peptide
HGH (somatotropin)
Outcome
IncreaseMemory normalization with physiological GH
Study
n: not reported in source
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · 2 yearsAs given in this study (human).
Source sentences
Summary
However, after 1 year of treatment a normalization of memory functioning was found in both groups of patients and this was preserved during the 2nd year of treatment.
4 context sentences(design, population, supporting numbers)
Summary · context
At 6 months memory only had improved in the group receiving supraphysiological GH treatment, but not in the group of patients who had a normalization of serum IGF-I.
Summary · context
The present study evaluates the effects of 2 years of growth hormone (GH) replacement therapy on psychological well-being and cognitive performance in adults with childhood-onset growth hormone deficiency (CO-GHD).
Summary · context
A total of 48 GHD adult men (mean age: 27 years) were randomly assigned to one of four treatment groups: placebo treatment, or GH replacement in a dose of 1, 2, or 3 IU/m2, respectively.
Summary · context
Placebo treatment was given for 6 months.
Report a problemFND-0961875105
04HumanNon-randomized trialEfficacy outcome
In adult men with childhood-onset GH deficiency, supraphysiological GH normalized memory after 1 year and maintained normalization during the 2nd year.
In plain wordsIn men with childhood-onset GH deficiency, supraphysiological GH normalized memory after 1 year, with normalization maintained during the 2nd year.
Peptide
HGH (somatotropin)
Outcome
IncreaseMemory normalization with supraphysiological GH
Study
n: not reported in source
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · 2 yearsAs given in this study (human).
Source sentences
Summary
However, after 1 year of treatment a normalization of memory functioning was found in both groups of patients and this was preserved during the 2nd year of treatment.
4 context sentences(design, population, supporting numbers)
Summary · context
At 6 months memory only had improved in the group receiving supraphysiological GH treatment, but not in the group of patients who had a normalization of serum IGF-I.
Summary · context
The present study evaluates the effects of 2 years of growth hormone (GH) replacement therapy on psychological well-being and cognitive performance in adults with childhood-onset growth hormone deficiency (CO-GHD).
Summary · context
A total of 48 GHD adult men (mean age: 27 years) were randomly assigned to one of four treatment groups: placebo treatment, or GH replacement in a dose of 1, 2, or 3 IU/m2, respectively.
Summary · context
Placebo treatment was given for 6 months.
Report a problemFND-0961875106
05HumanNon-randomized trialEfficacy outcome
In adult men with childhood-onset GH deficiency, psychological well-being did not change during GH replacement.
In plain wordsIn men with childhood-onset GH deficiency, psychological well-being did not change during GH treatment.
Peptide
HGH (somatotropin)
Outcome
No significant changePsychological well-being
Study
n: not reported in source
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
1, 2, or 3 IU/m2 · 2 yearsAs given in this study (human).
Source sentences
Summary
No changes were observed in psychological well-being and perceptual-motor skill.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study evaluates the effects of 2 years of growth hormone (GH) replacement therapy on psychological well-being and cognitive performance in adults with childhood-onset growth hormone deficiency (CO-GHD).
Summary · context
A total of 48 GHD adult men (mean age: 27 years) were randomly assigned to one of four treatment groups: placebo treatment, or GH replacement in a dose of 1, 2, or 3 IU/m2, respectively.
Summary · context
Placebo treatment was given for 6 months.
Report a problemFND-0961875107
06HumanNon-randomized trialEfficacy outcome
In adult men with childhood-onset GH deficiency, perceptual-motor skill did not change during GH replacement.
In plain wordsIn men with childhood-onset GH deficiency, perceptual-motor skill did not change during GH treatment.
Peptide
HGH (somatotropin)
Outcome
No significant changePerceptual-motor skill
Study
n: not reported in source
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
1, 2, or 3 IU/m2 · 2 yearsAs given in this study (human).
Source sentences
Summary
No changes were observed in psychological well-being and perceptual-motor skill.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study evaluates the effects of 2 years of growth hormone (GH) replacement therapy on psychological well-being and cognitive performance in adults with childhood-onset growth hormone deficiency (CO-GHD).
Summary · context
A total of 48 GHD adult men (mean age: 27 years) were randomly assigned to one of four treatment groups: placebo treatment, or GH replacement in a dose of 1, 2, or 3 IU/m2, respectively.
Summary · context
Placebo treatment was given for 6 months.
Report a problemFND-0961875108
07HumanObservational studyMechanism
In adult men with childhood-onset GH deficiency, memory changes correlated positively with GH-induced serum IGF-I changes during the placebo-controlled phase.
In plain wordsIn men with childhood-onset GH deficiency, memory changes during GH treatment correlated positively with blood IGF-I changes.
Peptide
HGH (somatotropin)
Outcome
Not applicableMemory correlation with IGF-I change
Study
n: not reported in source
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
1, 2, or 3 IU/m2 · 6 monthsAs given in this study (human).
Source sentences
Summary
During the placebo-controlled phase of the study the changes in memory performance were positively correlated to the GH induced changes in serum IGF-I concentration and, more weakly, to the daily GH substitution dose.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study evaluates the effects of 2 years of growth hormone (GH) replacement therapy on psychological well-being and cognitive performance in adults with childhood-onset growth hormone deficiency (CO-GHD).
Summary · context
A total of 48 GHD adult men (mean age: 27 years) were randomly assigned to one of four treatment groups: placebo treatment, or GH replacement in a dose of 1, 2, or 3 IU/m2, respectively.
Summary · context
Placebo treatment was given for 6 months.
Report a problemFND-0961875101
08HumanObservational studyMechanism
In adult men with childhood-onset GH deficiency, memory changes correlated weakly and positively with daily GH dose during the placebo-controlled phase.
In plain wordsIn men with childhood-onset GH deficiency, memory changes correlated weakly and positively with daily GH dose.
Peptide
HGH (somatotropin)
Outcome
Not applicableMemory correlation with daily GH dose
Study
n: not reported in source
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
1, 2, or 3 IU/m2 · 6 monthsAs given in this study (human).
Source sentences
Summary
During the placebo-controlled phase of the study the changes in memory performance were positively correlated to the GH induced changes in serum IGF-I concentration and, more weakly, to the daily GH substitution dose.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study evaluates the effects of 2 years of growth hormone (GH) replacement therapy on psychological well-being and cognitive performance in adults with childhood-onset growth hormone deficiency (CO-GHD).
Summary · context
A total of 48 GHD adult men (mean age: 27 years) were randomly assigned to one of four treatment groups: placebo treatment, or GH replacement in a dose of 1, 2, or 3 IU/m2, respectively.
Summary · context
Placebo treatment was given for 6 months.
Report a problemFND-0961875102

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · source ClinicalTrials.gov (opens in a new tab)

Status unknownPhase 2NCT04121780

Growth Hormone Replacement Therapy for Retried Professional Football Players

Center for Neurological Studiesn = 428 Oct 2019 to est. Sept 2026

TBI (Traumatic Brain Injury) · Concussion, Brain · Sport Injury · Anterior Pituitary Hyposecretion Syndrome · Hypopituitarism · Growth Hormone Deficiency

Trial page ClinicalTrials.govUpdated 8 Feb 2023

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:36 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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