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Study · Measured the body's own peptide · 1998

3 results

Substance P and vasoactive intestinal polypeptide but not calcitonin gene-related peptide concentrations are reduced in patients with moderate and severe ulcerative colitis.

Renzi D, Mantellini P, Calabrò A, Panerai C, Amorosi A, Paladini I, Salvadori G, Garcea MR, Surrenti C

Italian journal of gastroenterology and hepatology1 Feb 1998Cited by 29 (Europe PMC)

PMID9615269 (opens in a new tab)PepBankPUB-09615269
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In people with ulcerative colitis, the body's own VIP concentration in colonic biopsies was significantly lower than in control subjects.

    In plain wordsIn people with ulcerative colitis, the body's own VIP in the colon lining was lower than in controls.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseVIP concentration in colonic biopsy specimens
    Study

    n = 84

    Comparator
    Control subjects
    Outcome group
    Inflammation markers · Gastrointestinal

    Measurements

    P value
    < 0.01
    VIP tissue level versus controls

    Source sentences

    Summary
    Both Vasoactive Intestinal Polypeptide and Substance P concentrations were found to be significantly reduced in endoscopic biopsy specimens of patients with ulcerative colitis compared to controls (p < 0.01 and p = 0.05, respectively)
    2 context sentences
    Summary · context
    A total of 29 patients with active and 39 with inactive ulcerative colitis, and 16 control subjects took part in the study.
    Summary · context
    Biopsy specimens of colonic mucosa and blood samples were obtained from each subject, and neuropeptide concentrations were measured by sensitive and specific radioimmunoassays.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In people with ulcerative colitis, the reduction in the body's own tissue VIP appeared related to the degree of mucosal inflammation.

    In plain wordsIn people with ulcerative colitis, lower natural VIP in the colon lining appeared linked to more inflammation.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseTissue VIP versus degree of mucosal inflammation
    Study

    n = 84

    Outcome group
    Inflammation markers · Gastrointestinal

    Source sentences

    Summary
    and the reduction appeared to be related to the degree of mucosal inflammation
    2 context sentences
    Summary · context
    A total of 29 patients with active and 39 with inactive ulcerative colitis, and 16 control subjects took part in the study.
    Summary · context
    Biopsy specimens of colonic mucosa and blood samples were obtained from each subject, and neuropeptide concentrations were measured by sensitive and specific radioimmunoassays.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In people with ulcerative colitis, plasma levels of the body's own VIP did not differ significantly from control subjects.

    In plain wordsIn people with ulcerative colitis, natural VIP levels in blood were not different from controls.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changePlasma VIP level
    Study

    n = 84

    Comparator
    Control subjects
    Outcome group
    Inflammation markers · Gastrointestinal

    Source sentences

    Summary
    In addition, there was no significant difference in the neuropeptide plasma levels between ulcerative colitis patients and control subjects.
    2 context sentences
    Summary · context
    A total of 29 patients with active and 39 with inactive ulcerative colitis, and 16 control subjects took part in the study.
    Summary · context
    Biopsy specimens of colonic mucosa and blood samples were obtained from each subject, and neuropeptide concentrations were measured by sensitive and specific radioimmunoassays.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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