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Study · Not a test of the peptide alone · 1998

3 results

Plasma cortisol responses to three corticotrophic preparations in normal dogs.

Watson AD, Church DB, Emslie DR, Foster SF

Australian veterinary journal1 Apr 1998Cited by 16 (Europe PMC)

PMID9612546 (opens in a new tab)DOI10.1111/j.1751-0813.1998.tb10153.x (opens in a new tab)PepBankPUB-09612546
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cosyntropin.

  1. 01AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Other

    In normal dogs, intravenous tetracosactrin produced smaller mean peak cortisol concentrations than intramuscular ACTH.

    In plain wordsIn dogs, intravenous tetracosactrin produced lower peak cortisol than intramuscular ACTH.

    Peptide
    Cosyntropin
    Outcome
    DecreasePeak cortisol concentration
    Study

    dogsn = 8

    Clinically normal dogs
    Comparator
    Intramuscular ACTH preparations
    Outcome group
    Adrenal Response · Endocrine and hormones

    Source sentences

    Summary
    Tetracosactrin produced smaller mean peak cortisol concentrations, which tended to occur earlier than with ACTH, and smaller values for the area under the curve of plasma cortisol concentration from zero time to 4 h.
    2 context sentences
    Summary · context
    Eight clinically normal dogs (four intact males, four intact females) of medium size.ProceduresEach dog received four treatments on four separate occasions in a duplicated Latin square pattern.
    Summary · context
    Treatments were two adrenocorticotrophin (ACTH) preparations given intramuscularly at 2.2 U/kg, one of the ACTH preparations given intramuscularly at 1 U/kg and a synthetic polypeptide with ACTH-like activity (tetracosactrin, cosyntropin) given intravenously at 5 micrograms/kg.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  2. 02AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Other

    In normal dogs, cortisol peaks tended to occur earlier after tetracosactrin than after ACTH.

    In plain wordsIn dogs, cortisol tended to peak earlier after tetracosactrin than after ACTH.

    Peptide
    Cosyntropin
    Outcome
    DecreaseTime to peak cortisol
    Study

    dogsn = 8

    Clinically normal dogs
    Comparator
    Intramuscular ACTH preparations
    Outcome group
    Adrenal Response · Endocrine and hormones

    Source sentences

    Summary
    Tetracosactrin produced smaller mean peak cortisol concentrations, which tended to occur earlier than with ACTH, and smaller values for the area under the curve of plasma cortisol concentration from zero time to 4 h.
    2 context sentences
    Summary · context
    Eight clinically normal dogs (four intact males, four intact females) of medium size.ProceduresEach dog received four treatments on four separate occasions in a duplicated Latin square pattern.
    Summary · context
    Treatments were two adrenocorticotrophin (ACTH) preparations given intramuscularly at 2.2 U/kg, one of the ACTH preparations given intramuscularly at 1 U/kg and a synthetic polypeptide with ACTH-like activity (tetracosactrin, cosyntropin) given intravenously at 5 micrograms/kg.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  3. 03AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Other

    In normal dogs, tetracosactrin produced a smaller cortisol area under the curve through 4 h than ACTH.

    In plain wordsIn dogs, tetracosactrin produced less total cortisol exposure through 4 h than ACTH.

    Peptide
    Cosyntropin
    Outcome
    DecreaseCortisol area under the curve
    Study

    dogsn = 8

    Clinically normal dogs
    Comparator
    Intramuscular ACTH preparations
    Outcome group
    Adrenal Response · Endocrine and hormones

    Source sentences

    Summary
    Tetracosactrin produced smaller mean peak cortisol concentrations, which tended to occur earlier than with ACTH, and smaller values for the area under the curve of plasma cortisol concentration from zero time to 4 h.
    2 context sentences
    Summary · context
    Eight clinically normal dogs (four intact males, four intact females) of medium size.ProceduresEach dog received four treatments on four separate occasions in a duplicated Latin square pattern.
    Summary · context
    Treatments were two adrenocorticotrophin (ACTH) preparations given intramuscularly at 2.2 U/kg, one of the ACTH preparations given intramuscularly at 1 U/kg and a synthetic polypeptide with ACTH-like activity (tetracosactrin, cosyntropin) given intravenously at 5 micrograms/kg.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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