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Study · Randomized controlled trial · n = 7 · 1998

4 results

Evidence against a role for the growth hormone-releasing peptide axis in human slow-wave sleep regulation.

Moreno-Reyes R, Kerkhofs M, L'Hermite-Balériaux M, Thorner MO, Van Cauter E, Copinschi G

The American journal of physiology1 May 1998Cited by 15 (Europe PMC)

PMID9612233 (opens in a new tab)DOI10.1152/ajpendo.1998.274.5.e779 (opens in a new tab)PepBankPUB-09612233
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In young healthy men, a late-night intravenous injection of GHRP‑2 did not enhance slow-wave sleep compared with saline.

    In plain wordsIn healthy young men, a night-time GHRP‑2 injection did not increase deep sleep compared with saline.

    Peptide
    GHRP-2
    Outcome
    No significant changeSlow-wave sleep
    Study

    n = 7

    Comparator
    Saline
    Outcome group
    Sleep · Sleep
    Studied dose
    1 microgram/kg body wt · intravenous · single bolus injectionAs given in this study (human).

    Source sentences

    Summary
    Except for a nonsignificant tendency to increased amounts of wakefulness during the 1st h after the injection, no effects of GHRP-2 administration on sleep were detected. There was in particular no enhancement of SW sleep.
    1 context sentence
    Summary · context
    In the present study, the possible somnogenic effects induced under similar conditions by GH-releasing peptide (GHRP) were investigated in seven young healthy men. Bolus intravenous injections of GHRP-2 (1 microgram/kg body wt) or saline, in randomized order, were given after 60 s of the third rapid…
  2. 02HumanRandomized controlled trialEfficacy outcome

    GHRP‑2 produced a nonsignificant tendency to more wakefulness in the first hour after injection in young healthy men.

    In plain wordsIn healthy young men, GHRP‑2 did not significantly change time awake in the first hour after the injection.

    Peptide
    GHRP-2
    Outcome
    No significant changeWakefulness in the first hour after injection
    Study

    n = 7

    Comparator
    Saline
    Outcome group
    Sleep · Sleep
    Studied dose
    1 microgram/kg body wt · intravenous · single bolus injectionAs given in this study (human).

    Source sentences

    Summary
    Except for a nonsignificant tendency to increased amounts of wakefulness during the 1st h after the injection
    1 context sentence
    Summary · context
    In the present study, the possible somnogenic effects induced under similar conditions by GH-releasing peptide (GHRP) were investigated in seven young healthy men. Bolus intravenous injections of GHRP-2 (1 microgram/kg body wt) or saline, in randomized order, were given after 60 s of the third rapid…
  3. 03HumanRandomized controlled trialEfficacy outcome

    Each GHRP‑2 injection was followed immediately by a transient prolactin elevation in young healthy men.

    In plain wordsIn healthy young men, GHRP‑2 injections were followed by a short rise in prolactin.

    Peptide
    GHRP-2
    Outcome
    IncreaseProlactin after GHRP-2 injection
    Study

    n = 7

    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    1 microgram/kg body wt · intravenous · single bolus injectionAs given in this study (human).

    Source sentences

    Summary
    All GHRP injections were immediately followed by transient prolactin elevations
    1 context sentence
    Summary · context
    In the present study, the possible somnogenic effects induced under similar conditions by GH-releasing peptide (GHRP) were investigated in seven young healthy men. Bolus intravenous injections of GHRP-2 (1 microgram/kg body wt) or saline, in randomized order, were given after 60 s of the third rapid…
  4. 04HumanRandomized controlled trialEfficacy outcome

    Each GHRP‑2 injection was followed by a GH pulse within or around the upper limit of the physiological range in young healthy men.

    In plain wordsIn healthy young men, GHRP‑2 injections were followed by growth hormone pulses in or near the upper normal range.

    Peptide
    GHRP-2
    Outcome
    IncreaseGH pulses after GHRP-2 injection
    Study

    n = 7

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg body wt · intravenous · single bolus injectionAs given in this study (human).

    Source sentences

    Summary
    by GH pulses of a magnitude within or around the upper limit of the physiological range.
    1 context sentence
    Summary · context
    In the present study, the possible somnogenic effects induced under similar conditions by GH-releasing peptide (GHRP) were investigated in seven young healthy men. Bolus intravenous injections of GHRP-2 (1 microgram/kg body wt) or saline, in randomized order, were given after 60 s of the third rapid…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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