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Study · Animal study (in vivo) · rat · 1998

16 results

Effects of a weekly injection of human parathyroid hormone (1-34) and withdrawal on bone mass, strength, and turnover in mature ovariectomized rats.

Okimoto N, Tsurukami H, Okazaki Y, Nishida S, Sakai A, Ohnishi H, Hori M, Yasukawa K, Nakamura T

Bone1 May 1998Cited by 32 (Europe PMC)

PMID9600787 (opens in a new tab)DOI10.1016/s8756-3282(98)00024-6 (opens in a new tab)PepBankPUB-09600787
Publisher pagePubMedAsk about this study
Jump to 16 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study16

16 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, weekly hPTH maintained lumbar BMD.

    In plain wordsIn rats, weekly hPTH maintained lower spine bone density.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    Not applicableLumbar BMD
    Study

    Ratn: not reported in source

    Mature ovariectomized Wistar rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 or 90 microg/kg weekly · injection · 3 monthsAs given in this study (Rat).

    Source sentences

    Summary
    Weekly hPTH injections at doses of 10 or 90 microg/kg BW maintained the lumbar BMD values and increased the values of the femoral cortical bone, increasing the bone formation rates in the trabecular, endocortical, and periosteal envelopes.
    3 context sentences
    Summary · context
    One hundred fifteen Wistar rats, 7 months of age, were ovariectomized (ovx) or sham-operated to evaluate the effects of a weekly injection of human parathyroid hormone (hPTH) and withdrawal on the bone mass, strength, and turnover in mature ovariectomized rats.
    Summary · context
    At 3 months, ovx rats were given a weekly injection of hPTH(1-34) at the respective doses of 0 (vehicle), 10, and 90 microg/kg body weight (BW) for 3 months.
    Summary · context
    Then, hPTH-treated rats were divided into two groups each: continuously treated groups, and the groups treated with vehicle only for another 3 months.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, weekly hPTH increased femoral cortical bone values.

    In plain wordsIn rats, weekly hPTH increased femoral cortical bone measurements.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseFemoral cortical bone
    Study

    Ratn: not reported in source

    Mature ovariectomized Wistar rats
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 or 90 microg/kg weekly · injection · 3 monthsAs given in this study (Rat).

    Source sentences

    Summary
    Weekly hPTH injections at doses of 10 or 90 microg/kg BW maintained the lumbar BMD values and increased the values of the femoral cortical bone, increasing the bone formation rates in the trabecular, endocortical, and periosteal envelopes.
    3 context sentences
    Summary · context
    One hundred fifteen Wistar rats, 7 months of age, were ovariectomized (ovx) or sham-operated to evaluate the effects of a weekly injection of human parathyroid hormone (hPTH) and withdrawal on the bone mass, strength, and turnover in mature ovariectomized rats.
    Summary · context
    At 3 months, ovx rats were given a weekly injection of hPTH(1-34) at the respective doses of 0 (vehicle), 10, and 90 microg/kg body weight (BW) for 3 months.
    Summary · context
    Then, hPTH-treated rats were divided into two groups each: continuously treated groups, and the groups treated with vehicle only for another 3 months.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, weekly hPTH increased trabecular bone formation rates.

    In plain wordsIn rats, weekly hPTH increased spongy bone formation.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseTrabecular bone formation rate
    Study

    Ratn: not reported in source

    Mature ovariectomized Wistar rats
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 or 90 microg/kg weekly · injection · 3 monthsAs given in this study (Rat).

    Source sentences

    Summary
    Weekly hPTH injections at doses of 10 or 90 microg/kg BW maintained the lumbar BMD values and increased the values of the femoral cortical bone, increasing the bone formation rates in the trabecular, endocortical, and periosteal envelopes.
    3 context sentences
    Summary · context
    One hundred fifteen Wistar rats, 7 months of age, were ovariectomized (ovx) or sham-operated to evaluate the effects of a weekly injection of human parathyroid hormone (hPTH) and withdrawal on the bone mass, strength, and turnover in mature ovariectomized rats.
    Summary · context
    At 3 months, ovx rats were given a weekly injection of hPTH(1-34) at the respective doses of 0 (vehicle), 10, and 90 microg/kg body weight (BW) for 3 months.
    Summary · context
    Then, hPTH-treated rats were divided into two groups each: continuously treated groups, and the groups treated with vehicle only for another 3 months.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, weekly hPTH increased endocortical bone formation rates.

    In plain wordsIn rats, weekly hPTH increased bone formation at the inner cortical surface.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseEndocortical bone formation rate
    Study

    Ratn: not reported in source

    Mature ovariectomized Wistar rats
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 or 90 microg/kg weekly · injection · 3 monthsAs given in this study (Rat).

    Source sentences

    Summary
    Weekly hPTH injections at doses of 10 or 90 microg/kg BW maintained the lumbar BMD values and increased the values of the femoral cortical bone, increasing the bone formation rates in the trabecular, endocortical, and periosteal envelopes.
    3 context sentences
    Summary · context
    One hundred fifteen Wistar rats, 7 months of age, were ovariectomized (ovx) or sham-operated to evaluate the effects of a weekly injection of human parathyroid hormone (hPTH) and withdrawal on the bone mass, strength, and turnover in mature ovariectomized rats.
    Summary · context
    At 3 months, ovx rats were given a weekly injection of hPTH(1-34) at the respective doses of 0 (vehicle), 10, and 90 microg/kg body weight (BW) for 3 months.
    Summary · context
    Then, hPTH-treated rats were divided into two groups each: continuously treated groups, and the groups treated with vehicle only for another 3 months.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats, weekly hPTH increased periosteal bone formation rates.

    In plain wordsIn rats, weekly hPTH increased bone formation at the outer surface.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreasePeriosteal bone formation rate
    Study

    Ratn: not reported in source

    Mature ovariectomized Wistar rats
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 or 90 microg/kg weekly · injection · 3 monthsAs given in this study (Rat).

    Source sentences

    Summary
    Weekly hPTH injections at doses of 10 or 90 microg/kg BW maintained the lumbar BMD values and increased the values of the femoral cortical bone, increasing the bone formation rates in the trabecular, endocortical, and periosteal envelopes.
    3 context sentences
    Summary · context
    One hundred fifteen Wistar rats, 7 months of age, were ovariectomized (ovx) or sham-operated to evaluate the effects of a weekly injection of human parathyroid hormone (hPTH) and withdrawal on the bone mass, strength, and turnover in mature ovariectomized rats.
    Summary · context
    At 3 months, ovx rats were given a weekly injection of hPTH(1-34) at the respective doses of 0 (vehicle), 10, and 90 microg/kg body weight (BW) for 3 months.
    Summary · context
    Then, hPTH-treated rats were divided into two groups each: continuously treated groups, and the groups treated with vehicle only for another 3 months.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats, high-dose hPTH increased trabecular osteoclasts.

    In plain wordsIn rats, high-dose hPTH increased bone-resorbing cells in spongy bone.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseTrabecular osteoclasts
    Study

    Ratn: not reported in source

    Mature ovariectomized Wistar rats
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    90 microg/kg weekly · injection · 3 monthsAs given in this study (Rat).

    Source sentences

    Summary
    Trabecular osteoclasts were increased in the 90 microg/kg dose group.
    3 context sentences
    Summary · context
    One hundred fifteen Wistar rats, 7 months of age, were ovariectomized (ovx) or sham-operated to evaluate the effects of a weekly injection of human parathyroid hormone (hPTH) and withdrawal on the bone mass, strength, and turnover in mature ovariectomized rats.
    Summary · context
    At 3 months, ovx rats were given a weekly injection of hPTH(1-34) at the respective doses of 0 (vehicle), 10, and 90 microg/kg body weight (BW) for 3 months.
    Summary · context
    Then, hPTH-treated rats were divided into two groups each: continuously treated groups, and the groups treated with vehicle only for another 3 months.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats, hPTH decreased trabecular bone surface relative to volume.

    In plain wordsIn rats, hPTH decreased spongy bone surface relative to volume.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseTrabecular surface to volume
    Study

    Ratn: not reported in source

    Mature ovariectomized Wistar rats
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 or 90 microg/kg weekly · injection · 3 monthsAs given in this study (Rat).

    Source sentences

    Summary
    Trabecular bone surface relative to the volume was decreased by hPTH.
    3 context sentences
    Summary · context
    One hundred fifteen Wistar rats, 7 months of age, were ovariectomized (ovx) or sham-operated to evaluate the effects of a weekly injection of human parathyroid hormone (hPTH) and withdrawal on the bone mass, strength, and turnover in mature ovariectomized rats.
    Summary · context
    At 3 months, ovx rats were given a weekly injection of hPTH(1-34) at the respective doses of 0 (vehicle), 10, and 90 microg/kg body weight (BW) for 3 months.
    Summary · context
    Then, hPTH-treated rats were divided into two groups each: continuously treated groups, and the groups treated with vehicle only for another 3 months.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats, hPTH increased lumbar compressive load.

    In plain wordsIn rats, hPTH increased the compression load tolerated by lower spine bones.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseLumbar compressive load
    Study

    Ratn: not reported in source

    Mature ovariectomized Wistar rats
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 or 90 microg/kg weekly · injection · 3 monthsAs given in this study (Rat).

    Source sentences

    Summary
    The compressive load of the lumbar bone and the bending moment of the midfemur were increased.
    3 context sentences
    Summary · context
    One hundred fifteen Wistar rats, 7 months of age, were ovariectomized (ovx) or sham-operated to evaluate the effects of a weekly injection of human parathyroid hormone (hPTH) and withdrawal on the bone mass, strength, and turnover in mature ovariectomized rats.
    Summary · context
    At 3 months, ovx rats were given a weekly injection of hPTH(1-34) at the respective doses of 0 (vehicle), 10, and 90 microg/kg body weight (BW) for 3 months.
    Summary · context
    Then, hPTH-treated rats were divided into two groups each: continuously treated groups, and the groups treated with vehicle only for another 3 months.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats, hPTH increased midfemur bending moment.

    In plain wordsIn rats, hPTH increased the bending moment of the middle femur.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseMidfemur bending moment
    Study

    Ratn: not reported in source

    Mature ovariectomized Wistar rats
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 or 90 microg/kg weekly · injection · 3 monthsAs given in this study (Rat).

    Source sentences

    Summary
    The compressive load of the lumbar bone and the bending moment of the midfemur were increased.
    3 context sentences
    Summary · context
    One hundred fifteen Wistar rats, 7 months of age, were ovariectomized (ovx) or sham-operated to evaluate the effects of a weekly injection of human parathyroid hormone (hPTH) and withdrawal on the bone mass, strength, and turnover in mature ovariectomized rats.
    Summary · context
    At 3 months, ovx rats were given a weekly injection of hPTH(1-34) at the respective doses of 0 (vehicle), 10, and 90 microg/kg body weight (BW) for 3 months.
    Summary · context
    Then, hPTH-treated rats were divided into two groups each: continuously treated groups, and the groups treated with vehicle only for another 3 months.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In rats, hPTH increased lumbar compressive load corrected for BMD and volume.

    In plain wordsIn rats, hPTH increased lower spine compression strength after adjustment for bone density and volume.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseAdjusted lumbar compressive load
    Study

    Ratn: not reported in source

    Mature ovariectomized Wistar rats
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 or 90 microg/kg weekly · injection · 3 monthsAs given in this study (Rat).

    Source sentences

    Summary
    The lumbar compressive load values, corrected for BMD and volume, and the moment of inertia of the midfemur were also increased.
    3 context sentences
    Summary · context
    One hundred fifteen Wistar rats, 7 months of age, were ovariectomized (ovx) or sham-operated to evaluate the effects of a weekly injection of human parathyroid hormone (hPTH) and withdrawal on the bone mass, strength, and turnover in mature ovariectomized rats.
    Summary · context
    At 3 months, ovx rats were given a weekly injection of hPTH(1-34) at the respective doses of 0 (vehicle), 10, and 90 microg/kg body weight (BW) for 3 months.
    Summary · context
    Then, hPTH-treated rats were divided into two groups each: continuously treated groups, and the groups treated with vehicle only for another 3 months.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In rats, hPTH increased midfemur moment of inertia.

    In plain wordsIn rats, hPTH increased the middle femur's moment of inertia.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseMidfemur moment of inertia
    Study

    Ratn: not reported in source

    Mature ovariectomized Wistar rats
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 or 90 microg/kg weekly · injection · 3 monthsAs given in this study (Rat).

    Source sentences

    Summary
    The lumbar compressive load values, corrected for BMD and volume, and the moment of inertia of the midfemur were also increased.
    3 context sentences
    Summary · context
    One hundred fifteen Wistar rats, 7 months of age, were ovariectomized (ovx) or sham-operated to evaluate the effects of a weekly injection of human parathyroid hormone (hPTH) and withdrawal on the bone mass, strength, and turnover in mature ovariectomized rats.
    Summary · context
    At 3 months, ovx rats were given a weekly injection of hPTH(1-34) at the respective doses of 0 (vehicle), 10, and 90 microg/kg body weight (BW) for 3 months.
    Summary · context
    Then, hPTH-treated rats were divided into two groups each: continuously treated groups, and the groups treated with vehicle only for another 3 months.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In rats, hPTH did not increase intracortical porosity.

    In plain wordsIn rats, hPTH did not increase pores within cortical bone.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeIntracortical porosity
    Study

    Ratn: not reported in source

    Mature ovariectomized Wistar rats
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 or 90 microg/kg weekly · injection · 3 monthsAs given in this study (Rat).

    Source sentences

    Summary
    The intracortical porosity values were not increased by the treatment.
    3 context sentences
    Summary · context
    One hundred fifteen Wistar rats, 7 months of age, were ovariectomized (ovx) or sham-operated to evaluate the effects of a weekly injection of human parathyroid hormone (hPTH) and withdrawal on the bone mass, strength, and turnover in mature ovariectomized rats.
    Summary · context
    At 3 months, ovx rats were given a weekly injection of hPTH(1-34) at the respective doses of 0 (vehicle), 10, and 90 microg/kg body weight (BW) for 3 months.
    Summary · context
    Then, hPTH-treated rats were divided into two groups each: continuously treated groups, and the groups treated with vehicle only for another 3 months.
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In rats, lumbar BMD fell to OVX control levels after hPTH withdrawal.

    In plain wordsIn rats, lower spine bone density fell to untreated ovariectomized control levels after hPTH stopped.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseLumbar BMD after withdrawal
    Study

    Ratn: not reported in source

    Mature ovariectomized Wistar rats
    Comparator
    End of hPTH treatment
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 or 90 microg/kg weekly · injection · 3 monthsAs given in this study (Rat).

    Source sentences

    Summary
    After withdrawal of hPTH treatment, the BMD values in both the lumbar and the midfemur were reduced to ovx control levels.
    3 context sentences
    Summary · context
    One hundred fifteen Wistar rats, 7 months of age, were ovariectomized (ovx) or sham-operated to evaluate the effects of a weekly injection of human parathyroid hormone (hPTH) and withdrawal on the bone mass, strength, and turnover in mature ovariectomized rats.
    Summary · context
    At 3 months, ovx rats were given a weekly injection of hPTH(1-34) at the respective doses of 0 (vehicle), 10, and 90 microg/kg body weight (BW) for 3 months.
    Summary · context
    Then, hPTH-treated rats were divided into two groups each: continuously treated groups, and the groups treated with vehicle only for another 3 months.
  14. 14AnimalAnimal study (in vivo)Efficacy outcome

    In rats, midfemur BMD fell to OVX control levels after hPTH withdrawal.

    In plain wordsIn rats, middle femur bone density fell to untreated ovariectomized control levels after hPTH stopped.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseMidfemur BMD after withdrawal
    Study

    Ratn: not reported in source

    Mature ovariectomized Wistar rats
    Comparator
    End of hPTH treatment
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 or 90 microg/kg weekly · injection · 3 monthsAs given in this study (Rat).

    Source sentences

    Summary
    After withdrawal of hPTH treatment, the BMD values in both the lumbar and the midfemur were reduced to ovx control levels.
    3 context sentences
    Summary · context
    One hundred fifteen Wistar rats, 7 months of age, were ovariectomized (ovx) or sham-operated to evaluate the effects of a weekly injection of human parathyroid hormone (hPTH) and withdrawal on the bone mass, strength, and turnover in mature ovariectomized rats.
    Summary · context
    At 3 months, ovx rats were given a weekly injection of hPTH(1-34) at the respective doses of 0 (vehicle), 10, and 90 microg/kg body weight (BW) for 3 months.
    Summary · context
    Then, hPTH-treated rats were divided into two groups each: continuously treated groups, and the groups treated with vehicle only for another 3 months.
  15. 15AnimalAnimal study (in vivo)Efficacy outcome

    In rats, bone mass induced by high-dose hPTH declined faster after withdrawal than mass induced by low-dose hPTH.

    In plain wordsIn rats, bone mass declined faster after high-dose hPTH stopped than after low-dose hPTH stopped.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseBone mass loss after withdrawal
    Study

    Ratn: not reported in source

    Mature ovariectomized Wistar rats
    Comparator
    10 microg/kg weekly
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    90 microg/kg weekly · injection · 3 monthsAs given in this study (Rat).

    Source sentences

    Summary
    The bone mass stimulated by the 90 microg/kg dose was reduced faster than that by the 10 microg/kg dose.
    3 context sentences
    Summary · context
    One hundred fifteen Wistar rats, 7 months of age, were ovariectomized (ovx) or sham-operated to evaluate the effects of a weekly injection of human parathyroid hormone (hPTH) and withdrawal on the bone mass, strength, and turnover in mature ovariectomized rats.
    Summary · context
    At 3 months, ovx rats were given a weekly injection of hPTH(1-34) at the respective doses of 0 (vehicle), 10, and 90 microg/kg body weight (BW) for 3 months.
    Summary · context
    Then, hPTH-treated rats were divided into two groups each: continuously treated groups, and the groups treated with vehicle only for another 3 months.
  16. 16AnimalAnimal study (in vivo)Efficacy outcome

    In rats, bone strength parameters remained above OVX controls after hPTH cessation.

    In plain wordsIn rats, bone strength remained above untreated ovariectomized controls after hPTH stopped.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseBone strength after withdrawal
    Study

    Ratn: not reported in source

    Mature ovariectomized Wistar rats
    Comparator
    OVX controls
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 or 90 microg/kg weekly · injection · 3 monthsAs given in this study (Rat).

    Source sentences

    Summary
    However, the parameters of bone strength were still larger than those of the ovx controls after cessation of the hPTH treatment.
    3 context sentences
    Summary · context
    One hundred fifteen Wistar rats, 7 months of age, were ovariectomized (ovx) or sham-operated to evaluate the effects of a weekly injection of human parathyroid hormone (hPTH) and withdrawal on the bone mass, strength, and turnover in mature ovariectomized rats.
    Summary · context
    At 3 months, ovx rats were given a weekly injection of hPTH(1-34) at the respective doses of 0 (vehicle), 10, and 90 microg/kg body weight (BW) for 3 months.
    Summary · context
    Then, hPTH-treated rats were divided into two groups each: continuously treated groups, and the groups treated with vehicle only for another 3 months.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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