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Study · In vitro (cells) · sheep · 1998

8 results

Regulation of insulin-like growth factor-binding protein-5 by insulin-like growth factor I and interleukin-1alpha in ovine articular chondrocytes.

Sunic D, McNeil JD, Rayner TE, Andress DL, Belford DA

Endocrinology1 May 1998Cited by 31 (Europe PMC)

PMID9564845 (opens in a new tab)DOI10.1210/endo.139.5.5983 (opens in a new tab)PepBankPUB-09564845
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In ovine articular chondrocytes, LR3IGF-I, which has virtually no affinity for IGFBPs, had no effect on IGFBP-5 level, unlike IGF-I.

    In plain wordsIn sheep cartilage cells, LR3IGF-I had no effect on IGFBP-5 levels, unlike IGF-I.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeIGFBP-5 level in medium
    Study

    sheepn: not reported in source

    ovine articular chondrocytes
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Des(1-3)IGF-I, an IGF-I analog with reduced affinity for IGFBPs, also increased the level of IGFBP-5, but to a lesser extent than IGF-I, whereas LR3IGF-I, which has virtually no affinity for IGFBPs, had no effect on IGFBP-5.
  2. 02LabIn vitro (cells)Mechanism

    In ovine articular chondrocyte medium, LR3IGF-I did not inhibit IGFBP-5 degradation, unlike IGF-I.

    In plain wordsIn sheep cartilage cell cultures, LR3IGF-I did not slow IGFBP-5 breakdown, unlike IGF-I.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeIGFBP-5 proteolysis
    Study

    sheepn: not reported in source

    ovine articular chondrocytes
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The degradation of IGFBP-5 was significantly inhibited by IGF-I, but not by des(1-3)IGF-I or LR3IGF-I.
  3. 03LabIn vitro (cells)Efficacy outcome

    In ovine articular chondrocytes, LR3IGF-I was 10 times more potent than IGF-I in stimulating proteoglycan synthesis, indicating inhibition of IGF-I activity by endogenous IGFBPs.

    In plain wordsIn sheep cartilage cells, LR3IGF-I was 10 times more potent than IGF-I at stimulating proteoglycan synthesis.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseProteoglycan synthesis
    Study

    sheepn: not reported in source

    ovine articular chondrocytes
    Comparator
    IGF-I
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Measurements

    potency relative to IGF-I
    10 fold
    proteoglycan synthesis

    Source sentences

    Summary
    Des(1-3)IGF-I and LR3IGF-I were 10 times more potent than IGF-I in stimulating proteoglycan synthesis, indicating inhibition of IGF-I activity by endogenous IGFBPs.
  4. 04LabIn vitro (cells)Mechanism

    In ovine articular chondrocytes, des(1‑3)IGF-I increased IGFBP-5 levels, but less than IGF-I.

    In plain wordsIn cells from sheep, des(1‑3)IGF-I increased IGFBP-5 levels, but less than IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseIGFBP-5 level
    Study

    sheepn: not reported in source

    Ovine articular chondrocytes
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Des(1-3)IGF-I, an IGF-I analog with reduced affinity for IGFBPs, also increased the level of IGFBP-5, but to a lesser extent than IGF-I, whereas LR3IGF-I, which has virtually no affinity for IGFBPs, had no effect on IGFBP-5.
    1 context sentence
    Summary · context
    The aim of this study was to investigate the effects of IGF-I and IL-1 on IGFBP production by ovine articular chondrocytes (OAC) and the roles of these IGFBPs in the regulation of proteoglycan synthesis.
  5. 05LabIn vitro (cells)Mechanism

    In ovine articular chondrocytes, des(1‑3)IGF-I stimulated proteoglycan synthesis with greater potency than IGF-I.

    In plain wordsIn cells from sheep, des(1‑3)IGF-I stimulated proteoglycan production more potently than IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseProteoglycan synthesis potency
    Study

    sheepn: not reported in source

    Ovine articular chondrocytes
    Comparator
    IGF-I
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Measurements

    Relative potency
    10 fold
    versus IGF-I

    Source sentences

    Summary
    Des(1-3)IGF-I and LR3IGF-I were 10 times more potent than IGF-I in stimulating proteoglycan synthesis, indicating inhibition of IGF-I activity by endogenous IGFBPs.
    1 context sentence
    Summary · context
    The aim of this study was to investigate the effects of IGF-I and IL-1 on IGFBP production by ovine articular chondrocytes (OAC) and the roles of these IGFBPs in the regulation of proteoglycan synthesis.
  6. 06LabIn vitro (cell-free)Mechanism

    In ovine chondrocyte-conditioned medium, des(1‑3)IGF-I did not significantly inhibit IGFBP-5 degradation.

    In plain wordsIn lab tests with sheep cell medium, des(1‑3)IGF-I did not significantly inhibit IGFBP-5 breakdown.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeIGFBP-5 degradation
    Study

    sheepn: not reported in source

    Ovine articular chondrocyte-conditioned medium
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The degradation of IGFBP-5 was significantly inhibited by IGF-I, but not by des(1-3)IGF-I or LR3IGF-I.
    2 context sentences
    Summary · context
    Furthermore, IGFBP-5 underwent a time-dependent limited proteolysis when incubated with OAC-conditioned medium, degrading into 22- and 16-kDa fragments.
    Summary · context
    The aim of this study was to investigate the effects of IGF-I and IL-1 on IGFBP production by ovine articular chondrocytes (OAC) and the roles of these IGFBPs in the regulation of proteoglycan synthesis.

Studies that did not test the peptide alone2

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 07LabNot a test of IGF-1 LR3 aloneIn vitro (cells)Mechanism

    In ovine articular chondrocytes, IL-1alpha reduced IGF-I bioactivity but had no effect on the activity of the IGF-I analogs, including LR3IGF-I.

    In plain wordsIn sheep cartilage cells, IL-1alpha did not change the activity of LR3IGF-I, but it reduced the activity of IGF-I.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeLR3IGF-I bioactivity with IL-1alpha
    Study

    sheepn: not reported in source

    ovine articular chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    IL-1alpha reduced the IGF-I bioactivity, but had no effect on the activities of the IGF-I analogs

    In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.

  2. 08LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Mechanism

    In ovine articular chondrocytes, IL-1alpha did not alter the bioactivity of des(1‑3)IGF-I.

    In plain wordsIn cells from sheep, IL-1alpha did not change des(1‑3)IGF-I activity.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeProteoglycan synthesis response to IL-1alpha
    Study

    sheepn: not reported in source

    Ovine articular chondrocytes
    Comparator
    Without IL-1alpha
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    IL-1alpha reduced the IGF-I bioactivity, but had no effect on the activities of the IGF-I analogs
    2 context sentences
    Summary · context
    Des(1-3)IGF-I and LR3IGF-I were 10 times more potent than IGF-I in stimulating proteoglycan synthesis, indicating inhibition of IGF-I activity by endogenous IGFBPs.
    Summary · context
    The aim of this study was to investigate the effects of IGF-I and IL-1 on IGFBP production by ovine articular chondrocytes (OAC) and the roles of these IGFBPs in the regulation of proteoglycan synthesis.

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 3 to 4Current

    21 Oct 2026, 13:52 UTC

    The same notice was added 2 times, first on 21 Oct 2026, 12:50 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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