In both neuroblastoma cell lines, IGFBP-6 cDNA expression depressed des IGF-I mitogenic effects compared with control cells.
In plain wordsIn cells, IGFBP-6 gene expression reduced des IGF-I growth effects compared with control cells in both neuroblastoma cell lines.
- Peptide
- IGF-1 DES (des(1-3)IGF-I)
- Outcome
- DecreaseMitogenic response to des IGF-I
- Study
n: not reported in source
IGR-N-91 and SK-N-SH neuroblastoma cells transfected with IGFBP-6 cDNA- Comparator
- Control cells
- Outcome group
- Tumor growth · Cancer
Source sentences
showed that the mitogenic effects of serum, IGF-I, IGF-II, and des (1-3) IGF-I, a truncated IGF-I analogue with no affinity for IGFBP-6, were depressed in both transfected cell lines.
1 context sentence(design, population, supporting numbers)
We stably transfected IGR-N-91 and SK-N-SH neuroblastoma cells with an expression vector comprising IGFBP-6 cDNA, whose expression was placed under the control of the constitutive and ubiquitous cytomegalovirus promoter.
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).