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Study · Animal study (in vivo) · rat · 1998

4 results

The effect of MK-801 and of brain-derived polypeptides on the development of ischemic lesion induced by photothrombotic occlusion of the distal middle cerebral artery in rats.

Koroleva VI, Korolev OS, Loseva E, Bures J

Brain research1 Mar 1998Cited by 17 (Europe PMC)

PMID9554970 (opens in a new tab)DOI10.1016/s0006-8993(97)01448-0 (opens in a new tab)PepBankPUB-09554970
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats with photothrombotic ischemia, Cerebrolysin did not influence focal ischemic depolarization during the acute phase.

    In plain wordsIn rats with brain ischemia, Cerebrolysin did not change acute ischemic depolarization.

    Peptide
    Cerebrolysin
    Outcome
    Direction not reportedAcute focal ischemic depolarization
    Study

    ratn: not reported in source

    Photothrombotic distal middle cerebral artery occlusion
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    CL treatment (2.5 ml/kg, i.p. , 1 h after ischemia) did not influence FID in the acute phase of the experiment
    2 context sentences
    Summary · context
    The effect of neuroprotective drugs on the early and late electrophysiological manifestations of photothrombotic occlusion of distal branches of middle cerebral artery was studied in rats treated with MK-801 and Cerebrolysin (CL).
    Summary · context
    DC potentials were recorded from the irradiated cortex (ischemic core), from the adjacent penumbra zone and from remote intact cortex.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with photothrombotic ischemia, Cerebrolysin increased evoked spreading depression wave amplitude during post-ischemic recovery.

    In plain wordsIn rats with brain ischemia, Cerebrolysin increased recovery-related wave amplitude in the former penumbra.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseEvoked spreading depression wave amplitude
    Study

    ratn: not reported in source

    Photothrombotic distal middle cerebral artery occlusion
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg · intraperitoneal · 10 daysAs given in this study (rat).

    Source sentences

    Summary
    CL treatment (2.5 ml/kg, i.p. , 1 h after ischemia) did not influence FID in the acute phase of the experiment, but its 10-day administration facilitated post-ischemic recovery indicated by higher amplitude of evoked SD waves penetrating into the former penumbra zone.
    2 context sentences
    Summary · context
    The effect of neuroprotective drugs on the early and late electrophysiological manifestations of photothrombotic occlusion of distal branches of middle cerebral artery was studied in rats treated with MK-801 and Cerebrolysin (CL).
    Summary · context
    DC potentials were recorded from the irradiated cortex (ischemic core), from the adjacent penumbra zone and from remote intact cortex.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with photothrombotic ischemia, total necrosis volume was marginally reduced in the Cerebrolysin group.

    In plain wordsIn rats with brain ischemia, total tissue necrosis was marginally lower with Cerebrolysin.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseTotal necrosis volume
    Study

    ratn: not reported in source

    Photothrombotic distal middle cerebral artery occlusion
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Morphological examination showed that the volume of total and partial necrosis was increased in the MK-801 group and marginally reduced in the CL group.
    2 context sentences
    Summary · context
    The effect of neuroprotective drugs on the early and late electrophysiological manifestations of photothrombotic occlusion of distal branches of middle cerebral artery was studied in rats treated with MK-801 and Cerebrolysin (CL).
    Summary · context
    DC potentials were recorded from the irradiated cortex (ischemic core), from the adjacent penumbra zone and from remote intact cortex.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with photothrombotic ischemia, partial necrosis volume was marginally reduced in the Cerebrolysin group.

    In plain wordsIn rats with brain ischemia, partial tissue necrosis was marginally lower with Cerebrolysin.

    Peptide
    Cerebrolysin
    Outcome
    DecreasePartial necrosis volume
    Study

    ratn: not reported in source

    Photothrombotic distal middle cerebral artery occlusion
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Morphological examination showed that the volume of total and partial necrosis was increased in the MK-801 group and marginally reduced in the CL group.
    2 context sentences
    Summary · context
    The effect of neuroprotective drugs on the early and late electrophysiological manifestations of photothrombotic occlusion of distal branches of middle cerebral artery was studied in rats treated with MK-801 and Cerebrolysin (CL).
    Summary · context
    DC potentials were recorded from the irradiated cortex (ischemic core), from the adjacent penumbra zone and from remote intact cortex.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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