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Study · Animal study (in vivo) · 1998

5 results

Thymosin alpha 1 stimulates endothelial cell migration, angiogenesis, and wound healing.

Malinda KM, Sidhu GS, Banaudha KK, Gaddipati JP, Maheshwari RK, Goldstein AL, Kleinman HK

Journal of immunology (Baltimore, Md. : 1950)1 Jan 1998Cited by 25 (Europe PMC)

PMID9551940 (opens in a new tab)PepBankPUB-09551940
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In a subcutaneous in vivo model, thymosin alpha1 stimulated angiogenesis.

    In plain wordsIn animals, thymosin alpha‑1 stimulated new blood vessel growth under the skin.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseAngiogenesis in a subcutaneous model
    Study

    n: not reported in source

    subcutaneous angiogenesis model
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vivo, Talpha1 stimulated angiogenesis in a subcutaneous model.
    1 context sentence
    Summary · context
    We analyzed the effect of thymosin alpha1 (Talpha1) on endothelial cell migration, angiogenesis, and wound healing.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In a punch wound model, thymosin alpha1 given topically or intraperitoneally accelerated wound healing.

    In plain wordsIn animals, thymosin alpha‑1 applied to the skin or injected sped up wound healing.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseWound healing in a punch model
    Study

    n: not reported in source

    punch wound model
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · topical or intraperitonealAs given in this study.

    Source sentences

    Summary
    When given either topically or i.p., it accelerated wound healing in a punch model, demonstrating that Talpha1 promotes angiogenesis and wound healing.
    1 context sentence
    Summary · context
    We analyzed the effect of thymosin alpha1 (Talpha1) on endothelial cell migration, angiogenesis, and wound healing.
  3. 03LabIn vitro (cells)Activity measurement

    In cultured endothelial cells, thymosin alpha1 enhanced morphologic differentiation.

    In plain wordsIn cells in lab tests, thymosin alpha‑1 helped endothelial cells take on their typical form.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseMorphologic differentiation of endothelial cells
    Study

    n: not reported in source

    endothelial cells
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    enhanced the morphologic differentiation of endothelial cells and was a potent chemoattractant for endothelial cells and monocytes in vitro.
    1 context sentence
    Summary · context
    We analyzed the effect of thymosin alpha1 (Talpha1) on endothelial cell migration, angiogenesis, and wound healing.
  4. 04LabIn vitro (cells)Activity measurement

    In vitro, thymosin alpha1 was a potent chemoattractant for endothelial cells.

    In plain wordsIn cells in lab tests, thymosin alpha‑1 strongly attracted endothelial cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseEndothelial cell chemoattraction
    Study

    n: not reported in source

    endothelial cells
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    was a potent chemoattractant for endothelial cells and monocytes in vitro.
    1 context sentence
    Summary · context
    We analyzed the effect of thymosin alpha1 (Talpha1) on endothelial cell migration, angiogenesis, and wound healing.
  5. 05LabIn vitro (cells)Activity measurement

    In vitro, thymosin alpha1 was a potent chemoattractant for monocytes.

    In plain wordsIn cells in lab tests, thymosin alpha‑1 strongly attracted monocytes.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseMonocyte chemoattraction
    Study

    n: not reported in source

    monocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    was a potent chemoattractant for endothelial cells and monocytes in vitro.
    1 context sentence
    Summary · context
    We analyzed the effect of thymosin alpha1 (Talpha1) on endothelial cell migration, angiogenesis, and wound healing.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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