[Use of thymogen in the treatment of various forms of acute abdominal disorders in an experiment].

Reznikov KM, Filippova OV, Glukhov AA, Griaznov DV, Banin IN

Patologicheskaia fiziologiia i eksperimental'naia terapiia1 Jan 1998

PMID9542399PepBankPUB-09542399

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with acute abdominal disorders, thymogen lowered autoenzyme aggression assessed by serum alpha-amylolytic activity compared with untreated animals.
In plain wordsIn rats with acute abdominal disorders, thymogen lowered serum alpha-amylolytic activity compared with untreated animals.
Peptide
Thymogen (oglufanide)
Outcome
DecreaseSerum alpha-amylolytic activity
Study
Ratn: not reported in source
Male albino rats with acute pancreatitis and peritonitis
Comparator
Untreated animals
Outcome group
Organ injury · Gastrointestinal
Studied dose
Dose not stated · Intraperitoneal · 5 daysAs given in this study (Rat).
Source sentences
Summary
The results of the trial demonstrate that the degree of autoenzyme aggression (the data of blood serum alpha-amylolytic activity control) and the content of lipid peroxidation products (assessment of malonic dialdehyde quantity in tissue homogenate) were low in the experimental group as compared to…
2 context sentences(design, population, supporting numbers)
Summary · context
The authors have carried out experimental studies of thymogen action on the course of acute pancreatitis and acute peritonitis in white albino rat males.
Summary · context
The preparation was introduced into the abdominal cavity early after the modeling and every 24 hours for 5 days.
Report a problemFND-0954239901
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with acute abdominal disorders, thymogen lowered tissue lipid peroxidation products compared with untreated animals.
In plain wordsIn rats with acute abdominal disorders, thymogen lowered tissue lipid peroxidation products compared with untreated animals.
Peptide
Thymogen (oglufanide)
Outcome
DecreaseLipid peroxidation products
Study
Ratn: not reported in source
Male albino rats with acute pancreatitis and peritonitis
Comparator
Untreated animals
Outcome group
Oxidative stress · Whole body
Studied dose
Dose not stated · Intraperitoneal · 5 daysAs given in this study (Rat).
Source sentences
Summary
The results of the trial demonstrate that the degree of autoenzyme aggression (the data of blood serum alpha-amylolytic activity control) and the content of lipid peroxidation products (assessment of malonic dialdehyde quantity in tissue homogenate) were low in the experimental group as compared to…
2 context sentences(design, population, supporting numbers)
Summary · context
The authors have carried out experimental studies of thymogen action on the course of acute pancreatitis and acute peritonitis in white albino rat males.
Summary · context
The preparation was introduced into the abdominal cavity early after the modeling and every 24 hours for 5 days.
Report a problemFND-0954239902
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with acute abdominal disorders, thymogen attenuated depression of superoxide dismutase activity compared with untreated animals.
In plain wordsIn rats with acute abdominal disorders, thymogen preserved superoxide dismutase activity compared with untreated animals.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseSuperoxide dismutase activity
Study
Ratn: not reported in source
Male albino rats with acute pancreatitis and peritonitis
Comparator
Untreated animals
Outcome group
Oxidative stress · Whole body
Studied dose
Dose not stated · Intraperitoneal · 5 daysAs given in this study (Rat).
Source sentences
Summary
In the experimental group less pronounced depression of antiradical activity (superoxide dismutase and catalase activity control) was found, leukocytosis and leukocyte intoxication index were diminished.
2 context sentences(design, population, supporting numbers)
Summary · context
The authors have carried out experimental studies of thymogen action on the course of acute pancreatitis and acute peritonitis in white albino rat males.
Summary · context
The preparation was introduced into the abdominal cavity early after the modeling and every 24 hours for 5 days.
Report a problemFND-0954239903
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with acute abdominal disorders, thymogen attenuated depression of catalase activity compared with untreated animals.
In plain wordsIn rats with acute abdominal disorders, thymogen preserved catalase activity compared with untreated animals.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseCatalase activity
Study
Ratn: not reported in source
Male albino rats with acute pancreatitis and peritonitis
Comparator
Untreated animals
Outcome group
Oxidative stress · Whole body
Studied dose
Dose not stated · Intraperitoneal · 5 daysAs given in this study (Rat).
Source sentences
Summary
In the experimental group less pronounced depression of antiradical activity (superoxide dismutase and catalase activity control) was found, leukocytosis and leukocyte intoxication index were diminished.
2 context sentences(design, population, supporting numbers)
Summary · context
The authors have carried out experimental studies of thymogen action on the course of acute pancreatitis and acute peritonitis in white albino rat males.
Summary · context
The preparation was introduced into the abdominal cavity early after the modeling and every 24 hours for 5 days.
Report a problemFND-0954239904
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with acute abdominal disorders, thymogen diminished leukocytosis compared with untreated animals.
In plain wordsIn rats with acute abdominal disorders, thymogen reduced leukocytosis compared with untreated animals.
Peptide
Thymogen (oglufanide)
Outcome
DecreaseLeukocytosis
Study
Ratn: not reported in source
Male albino rats with acute pancreatitis and peritonitis
Comparator
Untreated animals
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · Intraperitoneal · 5 daysAs given in this study (Rat).
Source sentences
Summary
In the experimental group less pronounced depression of antiradical activity (superoxide dismutase and catalase activity control) was found, leukocytosis and leukocyte intoxication index were diminished.
2 context sentences(design, population, supporting numbers)
Summary · context
The authors have carried out experimental studies of thymogen action on the course of acute pancreatitis and acute peritonitis in white albino rat males.
Summary · context
The preparation was introduced into the abdominal cavity early after the modeling and every 24 hours for 5 days.
Report a problemFND-0954239905
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with acute abdominal disorders, thymogen diminished the leukocyte intoxication index compared with untreated animals.
In plain wordsIn rats with acute abdominal disorders, thymogen reduced the leukocyte intoxication index compared with untreated animals.
Peptide
Thymogen (oglufanide)
Outcome
DecreaseLeukocyte intoxication index
Study
Ratn: not reported in source
Male albino rats with acute pancreatitis and peritonitis
Comparator
Untreated animals
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · Intraperitoneal · 5 daysAs given in this study (Rat).
Source sentences
Summary
In the experimental group less pronounced depression of antiradical activity (superoxide dismutase and catalase activity control) was found, leukocytosis and leukocyte intoxication index were diminished.
2 context sentences(design, population, supporting numbers)
Summary · context
The authors have carried out experimental studies of thymogen action on the course of acute pancreatitis and acute peritonitis in white albino rat males.
Summary · context
The preparation was introduced into the abdominal cavity early after the modeling and every 24 hours for 5 days.
Report a problemFND-0954239906

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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