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Study · Animal study (in vivo) · rat · 1998

2 results

A role of the thymus and thymosin-alpha1 in brain NGF levels and NGF receptor expression.

Turrini P, Tirassa P, Vigneti E, Aloe L

Journal of neuroimmunology1 Feb 1998Cited by 15 (Europe PMC)

PMID9526847 (opens in a new tab)DOI10.1016/s0165-5728(97)00189-6 (opens in a new tab)PepBankPUB-09526847
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In thymectomized neonatal rats, intracerebral thymosin-alpha1 induced a partial recovery of brain NGF.

    In plain wordsIn rats lacking a thymus, thymosin alpha‑1 injected into the brain partly restored brain NGF levels.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseBrain NGF levels after thymectomy
    Study

    ratn: not reported in source

    neonatal thymectomized rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebralAs given in this study (rat).

    Source sentences

    Summary
    Intracerebral T-alpha1 injection in thymectomized animals induces a recovery, albeit not complete, of both NGF and p75NGFr.
    1 context sentence
    Summary · context
    Using neonatal rats we investigated the role of the thymus and thymosin-alpha1 (T-alpha1) in brain NGF levels, NGF receptor (p75NGFr) expression, as well as the activity of choline acetyl-transferase, a cholinergic enzyme regulated by NGF.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In thymectomized neonatal rats, intracerebral thymosin-alpha1 induced a partial recovery of p75NGFr expression.

    In plain wordsIn rats lacking a thymus, thymosin alpha‑1 injected into the brain partly restored a nerve growth factor receptor.

    Peptide
    Thymosin alpha-1
    Outcome
    Increasep75NGFr expression in basal forebrain cholinergic neurons
    Study

    ratn: not reported in source

    neonatal thymectomized rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebralAs given in this study (rat).

    Source sentences

    Summary
    Intracerebral T-alpha1 injection in thymectomized animals induces a recovery, albeit not complete, of both NGF and p75NGFr.
    1 context sentence
    Summary · context
    Using neonatal rats we investigated the role of the thymus and thymosin-alpha1 (T-alpha1) in brain NGF levels, NGF receptor (p75NGFr) expression, as well as the activity of choline acetyl-transferase, a cholinergic enzyme regulated by NGF.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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