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Study · Non-randomized trial · n = 17 · 1998

2 results

Growth hormone therapy of Turner's syndrome: beneficial effect on adult height.

Rosenfeld RG, Attie KM, Frane J, Brasel JA, Burstein S, Cara JF, Chernausek S, Gotlin RW, Kuntze J, Lippe BM, Mahoney CP, Moore WV, Saenger P, Johanson AJ

The Journal of pediatrics1 Feb 1998Cited by 128 (Europe PMC)

PMID9506648 (opens in a new tab)DOI10.1016/s0022-3476(98)70452-4 (opens in a new tab)PepBankPUB-09506648
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In girls with Turner syndrome, GH alone produced an adult height of 150.4+/-5.5 cm.

    In plain wordsIn girls with Turner syndrome, GH alone produced an adult height of 150.4+/-5.5 cm.

    Peptide
    HGH (somatotropin)
    Outcome
    Not applicableAdult height
    Study

    n = 17

    Outcome group
    Linear growth · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Adult height
    150.4 cm
    GH-alone group, mean (SD 5.5 cm)

    Source sentences

    Summary
    The 17 subjects receiving GH alone all completed the trial and reached a height of 150.4+/-5.5 cm (mean +/- SD), 8.4+/-4.5 cm taller than their mean projected adult height at enrollment (95% confidence interval [CI]: 6.3 to 10.6 cm).
    2 context sentences
    Summary · context
    To carry out a multicenter, prospective, randomized trial of human growth hormone (GH), alone or in combination with oxandrolone (OX), in patients with Turner's syndrome (TS).
    Summary · context
    After completion of the first phase, group 3 subjects continued to receive GH only.
  2. 02HumanNon-randomized trialEfficacy outcome

    In girls with Turner syndrome, adult height after GH alone exceeded projected height by 8.4+/-4.5 cm (95% CI: 6.3 to 10.6 cm).

    In plain wordsIn girls with Turner syndrome, adult height after GH alone exceeded projected height by 8.4+/-4.5 cm.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseAdult height versus projected height
    Study

    n = 17

    Comparator
    Projected adult height at enrollment
    Outcome group
    Linear growth · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Adult height gain over projected adult height at enrollment
    8.4 cm
    GH-alone group, mean (SD 4.5 cm)
    95% CI of adult height gain over projected height
    6.3 to 10.6 cm
    GH-alone group

    Source sentences

    Summary
    The 17 subjects receiving GH alone all completed the trial and reached a height of 150.4+/-5.5 cm (mean +/- SD), 8.4+/-4.5 cm taller than their mean projected adult height at enrollment (95% confidence interval [CI]: 6.3 to 10.6 cm).
    2 context sentences
    Summary · context
    To carry out a multicenter, prospective, randomized trial of human growth hormone (GH), alone or in combination with oxandrolone (OX), in patients with Turner's syndrome (TS).
    Summary · context
    After completion of the first phase, group 3 subjects continued to receive GH only.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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