Ameliorative influence of a nootropic drug on motor activity of rats after bilateral carotid artery occlusion.

Gschanes A, Valousková V, Windisch M

Journal of neural transmission (Vienna, Austria : 1996)1 Jan 1997Cited by 18 (Europe PMC)

PMID9503278DOI10.1007/bf01294733PepBankPUB-09503278

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In intact rats, high-dose Cerebrolysin infusion decreased motor activity compared with saline controls.
In plain wordsIn rats without ischemia, high-dose Cerebrolysin infusion decreased motor activity compared with saline controls.
Peptide
Cerebrolysin
Outcome
DecreaseMotor activity at high dose
Study
ratn: not reported in source
Intact rats
Comparator
Saline
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
0.57 mg/day · intraventricular infusionAs given in this study (rat).
Source sentences
Summary
Infusion (i.v.) of a high dose of Cerebrolysin (0.57 mg/day) decreased motor activity and spatial memory of intact rats (p < 0.01 and p < 0.05, respectively) but low dose of Cerebrolysin was well tolerated in the intact animals.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of the peptidergic nootropic drug Cerebrolysin on spatial memory and motor activity were examined in intact and ischemic rats.
Summary · context
Immediately afterwards Cerebrolysin or saline was administered, either by continuous intraventricular (i.v.) infusion or by daily intraperitoneal (i.p.) injection.
Report a problemFND-0950327801
02AnimalAnimal study (in vivo)Efficacy outcome
In intact rats, high-dose Cerebrolysin infusion decreased spatial memory compared with saline controls.
In plain wordsIn rats without ischemia, high-dose Cerebrolysin infusion decreased spatial memory compared with saline controls.
Peptide
Cerebrolysin
Outcome
DecreaseSpatial memory at high dose
Study
ratn: not reported in source
Intact rats
Comparator
Saline
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
0.57 mg/day · intraventricular infusionAs given in this study (rat).
Source sentences
Summary
Infusion (i.v.) of a high dose of Cerebrolysin (0.57 mg/day) decreased motor activity and spatial memory of intact rats (p < 0.01 and p < 0.05, respectively) but low dose of Cerebrolysin was well tolerated in the intact animals.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of the peptidergic nootropic drug Cerebrolysin on spatial memory and motor activity were examined in intact and ischemic rats.
Summary · context
Immediately afterwards Cerebrolysin or saline was administered, either by continuous intraventricular (i.v.) infusion or by daily intraperitoneal (i.p.) injection.
Report a problemFND-0950327802
03AnimalAnimal study (in vivo)Safety outcome
In intact rats, low-dose Cerebrolysin was well tolerated.
In plain wordsIn rats without ischemia, low-dose Cerebrolysin was well tolerated.
Peptide
Cerebrolysin
Outcome
Not applicableLow-dose tolerance
Study
ratn: not reported in source
Intact rats
Outcome group
Adverse events · Nervous system and cognition
Studied dose
low dose · intraventricular infusionAs given in this study (rat).
Source sentences
Summary
Infusion (i.v.) of a high dose of Cerebrolysin (0.57 mg/day) decreased motor activity and spatial memory of intact rats (p < 0.01 and p < 0.05, respectively) but low dose of Cerebrolysin was well tolerated in the intact animals.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of the peptidergic nootropic drug Cerebrolysin on spatial memory and motor activity were examined in intact and ischemic rats.
Summary · context
Immediately afterwards Cerebrolysin or saline was administered, either by continuous intraventricular (i.v.) infusion or by daily intraperitoneal (i.p.) injection.
Report a problemFND-0950327803
04AnimalAnimal study (in vivo)Efficacy outcome
In ischemic rats, Cerebrolysin infusion improved motor activity compared with saline-treated ischemic controls, to the level of intact controls.
In plain wordsIn rats with ischemia, Cerebrolysin infusion counteracted motor impairment compared with ischemic controls.
Peptide
Cerebrolysin
Outcome
IncreaseMotor recovery with infusion
Study
ratn: not reported in source
Ischemic-hypoxic injury
Comparator
Saline
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
0.0057 mg/day · intraventricular infusionAs given in this study (rat).
Source sentences
Summary
Cerebrolysin significantly counteracted deleterious motor changes due to ischemia up to the level of intact controls after both i.v. infusion (0.0057 mg/day) and daily i.p. drug administration (100 mg/kg bw and day) indicating an accelerating recovery after ischemia.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of the peptidergic nootropic drug Cerebrolysin on spatial memory and motor activity were examined in intact and ischemic rats.
Summary · context
Immediately afterwards Cerebrolysin or saline was administered, either by continuous intraventricular (i.v.) infusion or by daily intraperitoneal (i.p.) injection.
Report a problemFND-0950327804
05AnimalAnimal study (in vivo)Efficacy outcome
In ischemic rats, Cerebrolysin injection improved motor activity compared with saline-treated ischemic controls, to the level of intact controls.
In plain wordsIn rats with ischemia, daily Cerebrolysin injection counteracted motor impairment compared with ischemic controls.
Peptide
Cerebrolysin
Outcome
IncreaseMotor recovery with injection
Study
ratn: not reported in source
Ischemic-hypoxic injury
Comparator
Saline
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
100 mg/kg bw and day · intraperitoneal injectionAs given in this study (rat).
Source sentences
Summary
Cerebrolysin significantly counteracted deleterious motor changes due to ischemia up to the level of intact controls after both i.v. infusion (0.0057 mg/day) and daily i.p. drug administration (100 mg/kg bw and day) indicating an accelerating recovery after ischemia.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of the peptidergic nootropic drug Cerebrolysin on spatial memory and motor activity were examined in intact and ischemic rats.
Summary · context
Immediately afterwards Cerebrolysin or saline was administered, either by continuous intraventricular (i.v.) infusion or by daily intraperitoneal (i.p.) injection.
Report a problemFND-0950327805

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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