Characterisation of the biological effects of neurohypophysial peptides on seminiferous tubules.

Harris GC, Nicholson HD

The Journal of endocrinology1 Jan 1998Cited by 15 (Europe PMC)

PMID9496231DOI10.1677/joe.0.1560035PepBankPUB-09496231

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

1 result from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueActivity measurement
In perifused rat seminiferous tubules, oxytocin increased tubule contractility, with vasopressin at least 10 times more potent.
In plain wordsIn rat testis tissue in the lab, oxytocin made the sperm-carrying tubules contract more, though vasopressin was at least 10 times stronger.
Peptide
Oxytocin
Outcome
IncreaseSeminiferous tubule contractility after oxytocin
Study
ratn: not reported in source
Perifused seminiferous tubule segments from adult rat testes
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
2 nM · perifusionAs given in this study (rat).
Source sentences
Summary
Both OT and AVP increased tubule contractility, with AVP being at least 10 times more potent than OT.
1 context sentence(design, population, supporting numbers)
Summary · context
Adult rat testes were placed in fresh oxygenated Dulbecco's modified Eagle's medium (DMEM) F12 medium, decapsulated and the tubules gently teased apart. A small section of tubule was placed in a microslide chamber and perifused with medium. Seminiferous tubules were treated with OT (2 nM), [Arg8]-va…
Report a problemFND-0949623101

Studies that did not test the peptide alone5

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

02LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement
In perifused rat seminiferous tubules, the selective oxytocin antagonist OTA significantly reduced oxytocin-induced contractility and did not affect vasopressin-induced responses.
In plain wordsIn rat testis tissue in the lab, an oxytocin blocker reduced the contraction that oxytocin caused.
Peptide
Oxytocin
Outcome
DecreaseOxytocin antagonist OTA on oxytocin-induced contractility
Study
ratn: not reported in source
Perifused seminiferous tubule segments from adult rat testes
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
Treatment with the selective OT antagonist, desGly-NH2,d(CH2)5[d-Tyr2,Thr4]-ornithine vasotocin (OTA, 0.2 microM and 2 microM) significantly reduced OT-induced increases in seminiferous tubule contractility but had no effect on AVP-induced responses.
1 context sentence(design, population, supporting numbers)
Summary · context
Adult rat testes were placed in fresh oxygenated Dulbecco's modified Eagle's medium (DMEM) F12 medium, decapsulated and the tubules gently teased apart. A small section of tubule was placed in a microslide chamber and perifused with medium. Seminiferous tubules were treated with OT (2 nM), [Arg8]-va…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0949623102
03LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement
In perifused rat seminiferous tubules, the vasopressin antagonist AVPA reduced oxytocin-induced responses, but it was more potent against vasopressin-induced responses.
In plain wordsIn rat testis tissue in the lab, a vasopressin blocker reduced oxytocin-caused contraction, but it worked better against vasopressin-caused contraction.
Peptide
Oxytocin
Outcome
DecreaseVasopressin antagonist AVPA on oxytocin-induced contractility
Study
ratn: not reported in source
Perifused seminiferous tubule segments from adult rat testes
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
In contrast, the AVP antagonist, Phaa-d-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Arg-Tyr-NH2 (AVPA) was more potent at reducing AVP-induced increases than OT-induced responses.
1 context sentence(design, population, supporting numbers)
Summary · context
Adult rat testes were placed in fresh oxygenated Dulbecco's modified Eagle's medium (DMEM) F12 medium, decapsulated and the tubules gently teased apart. A small section of tubule was placed in a microslide chamber and perifused with medium. Seminiferous tubules were treated with OT (2 nM), [Arg8]-va…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0949623103
04LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement
In perifused rat seminiferous tubules, the non-peptide vasopressin antagonist SR 49059 blocked the response to oxytocin and to vasopressin in a similar manner.
In plain wordsIn rat testis tissue in the lab, the blocker SR 49059 stopped the response to oxytocin and to vasopressin about equally.
Peptide
Oxytocin
Outcome
DecreaseSR 49059 on oxytocin-induced contractility
Study
ratn: not reported in source
Perifused seminiferous tubule segments from adult rat testes
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
The selective non-peptide AVPA SR 49059 blocked the response to both peptides in a similar manner
1 context sentence(design, population, supporting numbers)
Summary · context
Adult rat testes were placed in fresh oxygenated Dulbecco's modified Eagle's medium (DMEM) F12 medium, decapsulated and the tubules gently teased apart. A small section of tubule was placed in a microslide chamber and perifused with medium. Seminiferous tubules were treated with OT (2 nM), [Arg8]-va…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0949623104
05LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement
In perifused rat seminiferous tubules, the non-peptide oxytocin antagonist L367,773 did not block oxytocin-induced increases in contractility.
In plain wordsIn rat testis tissue in the lab, the oxytocin blocker L367,773 did not stop the contraction that oxytocin caused.
Peptide
Oxytocin
Outcome
No significant changeL367,773 on oxytocin-induced contractility
Study
ratn: not reported in source
Perifused seminiferous tubule segments from adult rat testes
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
the non-peptide OTA L367,773 did not block OT-induced increases in seminiferous tubule contractility at doses that were slightly inhibitory to AVP-induced responses.
1 context sentence(design, population, supporting numbers)
Summary · context
Adult rat testes were placed in fresh oxygenated Dulbecco's modified Eagle's medium (DMEM) F12 medium, decapsulated and the tubules gently teased apart. A small section of tubule was placed in a microslide chamber and perifused with medium. Seminiferous tubules were treated with OT (2 nM), [Arg8]-va…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0949623105
06LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement
In perifused rat seminiferous tubules, the specific oxytocin agonist TGOT did not induce a contractile response.
In plain wordsIn rat testis tissue in the lab, an oxytocin-like compound (TGOT) did not make the tubules contract.
Peptide
Oxytocin
Outcome
No significant changeSeminiferous tubule contractility after TGOT
Study
ratn: not reported in source
Perifused seminiferous tubule segments from adult rat testes
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
The specific OT agonist TGOT did not induce a contractile response.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0949623106

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:54 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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