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Study · Animal study (in vivo) · rat · 1998

5 results

Effects of chronic central infusion of oxytocin on the response of the magnocellular neuroendocrine system to osmotic stimulation.

Koehler-Stec EM, Byers A, Summy-Long JY

Pharmacology1 Feb 1998Cited by 1 (Europe PMC)

PMID9494068 (opens in a new tab)DOI10.1159/000028187 (opens in a new tab)PepBankPUB-09494068
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, chronic intracerebroventricular oxytocin infusion raised basal plasma oxytocin versus artificial CSF (p < 0.01).

    In plain wordsIn rats, a week of oxytocin infused into the brain raised baseline blood oxytocin compared with control fluid.

    Peptide
    Oxytocin
    Outcome
    IncreaseBasal plasma oxytocin
    Study

    ratn: not reported in source

    Ovariectomized rats given gonadal steroids to simulate late gestation or lactation
    Comparator
    Artificial cerebrospinal fluid
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    2 ng/microg at 0.5 microl/h · intracerebroventricular infusion · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Animals infused centrally with OT had higher basal levels of OT in plasma (p < 0.01 vs. CSF).
    1 context sentence
    Summary · context
    The effect of continuous intracerebroventricular (i.c.v.) infusion of oxytocin (OT) on the release of OT and vasopressin (VP) following osmotic stimulation was studied in ovariectomized rats treated peripherally with gonadal steroids to simulate late gestation/lactation.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, chronic intracerebroventricular oxytocin infusion enhanced the rise in circulating vasopressin after osmotic stimulation versus artificial CSF (p < 0.01).

    In plain wordsIn rats, a week of oxytocin infused into the brain increased the vasopressin rise after a salt challenge, compared with control fluid.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma vasopressin response to osmotic stimulation
    Study

    ratn: not reported in source

    Ovariectomized rats given gonadal steroids to simulate late gestation or lactation
    Comparator
    Artificial cerebrospinal fluid
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    2 ng/microg at 0.5 microl/h · intracerebroventricular infusion · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    only circulating VP was enhanced further (p < 0.01) in animals infused with OT compared with those receiving CSF.
    1 context sentence
    Summary · context
    The effect of continuous intracerebroventricular (i.c.v.) infusion of oxytocin (OT) on the release of OT and vasopressin (VP) following osmotic stimulation was studied in ovariectomized rats treated peripherally with gonadal steroids to simulate late gestation/lactation.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, chronic oxytocin infusion did not enhance the plasma oxytocin response to osmotic stimulation further than artificial CSF did.

    In plain wordsIn rats, a week of oxytocin infused into the brain did not change the oxytocin rise after a salt challenge compared with control fluid.

    Peptide
    Oxytocin
    Outcome
    No significant changePlasma oxytocin response to osmotic stimulation
    Study

    ratn: not reported in source

    Ovariectomized rats given gonadal steroids to simulate late gestation or lactation
    Comparator
    Artificial cerebrospinal fluid
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    2 ng/microg at 0.5 microl/h · intracerebroventricular infusion · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    While osmotic stimulation increased plasma levels of both OT and VP (0.15 mol/l NaCl < 1.5 mol/l NaCl; p < 0.01), only circulating VP was enhanced further (p < 0.01) in animals infused with OT compared with those receiving CSF.
    1 context sentence
    Summary · context
    The effect of continuous intracerebroventricular (i.c.v.) infusion of oxytocin (OT) on the release of OT and vasopressin (VP) following osmotic stimulation was studied in ovariectomized rats treated peripherally with gonadal steroids to simulate late gestation/lactation.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, differences in neural lobe stores of oxytocin or vasopressin did not explain the hormone changes after oxytocin infusion.

    In plain wordsIn rats, hormone stores in the pituitary neural lobe did not explain the changes seen after oxytocin infusion.

    Peptide
    Oxytocin
    Outcome
    No significant changeNeural lobe stores of oxytocin and vasopressin
    Study

    ratn: not reported in source

    Ovariectomized rats given gonadal steroids to simulate late gestation or lactation
    Comparator
    Artificial cerebrospinal fluid
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    2 ng/microg at 0.5 microl/h · intracerebroventricular infusion · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    These changes in hormone levels could not be explained by differences in neural lobe stores of OT or VP or by alterations in daily water intake during the infusion period.
    1 context sentence
    Summary · context
    The effect of continuous intracerebroventricular (i.c.v.) infusion of oxytocin (OT) on the release of OT and vasopressin (VP) following osmotic stimulation was studied in ovariectomized rats treated peripherally with gonadal steroids to simulate late gestation/lactation.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, alterations in daily water intake during the infusion did not explain the hormone changes after oxytocin infusion.

    In plain wordsIn rats, changes in daily water intake did not explain the hormone changes seen after oxytocin infusion.

    Peptide
    Oxytocin
    Outcome
    No significant changeDaily water intake during infusion
    Study

    ratn: not reported in source

    Ovariectomized rats given gonadal steroids to simulate late gestation or lactation
    Comparator
    Artificial cerebrospinal fluid
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    2 ng/microg at 0.5 microl/h · intracerebroventricular infusion · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    These changes in hormone levels could not be explained by differences in neural lobe stores of OT or VP or by alterations in daily water intake during the infusion period.
    1 context sentence
    Summary · context
    The effect of continuous intracerebroventricular (i.c.v.) infusion of oxytocin (OT) on the release of OT and vasopressin (VP) following osmotic stimulation was studied in ovariectomized rats treated peripherally with gonadal steroids to simulate late gestation/lactation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

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