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Study · In vitro (cells) · mouse · 1998

1 result

Retrovirally mediated overexpression of insulin-like growth factor binding protein 4: evidence that insulin-like growth factor is required for skeletal muscle differentiation.

Damon SE, Haugk KL, Birnbaum RS, Quinn LS

Journal of cellular physiology1 Apr 1998Cited by 30 (Europe PMC)

PMID9491786 (opens in a new tab)DOI10.1002/(sici)1097-4652(199804)175:1<109::aid-jcp12>3.0.co;2-6 (opens in a new tab)PepBankPUB-09491786
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In IGFBP-4-overexpressing mouse C2 myoblasts, des(1‑3)IGF-I restored differentiation.

    In plain wordsIn mouse cells that overexpressed IGFBP-4, des(1‑3)IGF-I restored muscle cell differentiation.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseMyoblast differentiation
    Study

    mousen: not reported in source

    C2-BP4 myoblasts overexpressing IGFBP-4
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Differentiation was restored in C2-BP4 cells by treatment with high levels of exogenous IGF-I or with des(1-3)IGF-I, an analog of IGF-I with reduced affinity for IGFBPs.
    1 context sentence
    Summary · context
    To address this issue directly, we used a retroviral vector (LBP4SN) to develop a subline of mouse C2 myoblasts (C2-BP4) that constitutively overexpress IGF binding protein-4 (IGFBP-4).

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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