Long [R3] insulin-like growth factor-I reduces growth, plasma growth hormone, IGF binding protein-3 and endogenous IGF-I concentrations in pigs.

Dunaiski V, Dunshea FR, Walton PE, Goddard C

The Journal of endocrinology1 Dec 1997Cited by 12 (Europe PMC)

PMID9488001DOI10.1677/joe.0.1550559PepBankPUB-09488001

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In finisher pigs, a four-day infusion of LR3IGF-I decreased average daily gain.
In plain wordsIn pigs, a four-day LR3IGF-I infusion lowered daily weight gain.
Peptide
IGF-1 LR3
Outcome
DecreaseAverage daily gain
Study
pign: not reported in source
finisher pigs
Outcome group
Body weight · Metabolic and weight
Studied dose
180 micrograms/kg/day · infusion · 4 daysAs given in this study (pig).
Source sentences
Summary
A four-day infusion of Long [R3] IGF-I (LR3IGF-I; 180 micrograms/kg/day) decreased the average daily gain, food intake, and plasma IGFBP-3, IGF-I and insulin concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
This study was designed to determine the effect of IGF peptides alone or in combination with porcine GH (pGH) on growth characteristics and plasma hormone concentrations in finisher pigs.
Report a problemFND-0948800101
02AnimalAnimal study (in vivo)Efficacy outcome
In finisher pigs, a four-day infusion of LR3IGF-I decreased food intake.
In plain wordsIn pigs, a four-day LR3IGF-I infusion lowered food intake.
Peptide
IGF-1 LR3
Outcome
DecreaseFood intake
Study
pign: not reported in source
finisher pigs
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
180 micrograms/kg/day · infusion · 4 daysAs given in this study (pig).
Source sentences
Summary
A four-day infusion of Long [R3] IGF-I (LR3IGF-I; 180 micrograms/kg/day) decreased the average daily gain, food intake, and plasma IGFBP-3, IGF-I and insulin concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
This study was designed to determine the effect of IGF peptides alone or in combination with porcine GH (pGH) on growth characteristics and plasma hormone concentrations in finisher pigs.
Report a problemFND-0948800102
03AnimalAnimal study (in vivo)Mechanism
In finisher pigs, a four-day infusion of LR3IGF-I decreased plasma IGFBP-3.
In plain wordsIn pigs, a four-day LR3IGF-I infusion lowered blood IGFBP-3.
Peptide
IGF-1 LR3
Outcome
DecreasePlasma IGFBP-3
Study
pign: not reported in source
finisher pigs
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
180 micrograms/kg/day · infusion · 4 daysAs given in this study (pig).
Source sentences
Summary
A four-day infusion of Long [R3] IGF-I (LR3IGF-I; 180 micrograms/kg/day) decreased the average daily gain, food intake, and plasma IGFBP-3, IGF-I and insulin concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
This study was designed to determine the effect of IGF peptides alone or in combination with porcine GH (pGH) on growth characteristics and plasma hormone concentrations in finisher pigs.
Report a problemFND-0948800103
04AnimalAnimal study (in vivo)Mechanism
In finisher pigs, a four-day infusion of LR3IGF-I decreased plasma IGF-I.
In plain wordsIn pigs, a four-day LR3IGF-I infusion lowered blood IGF-I.
Peptide
IGF-1 LR3
Outcome
DecreasePlasma IGF-I
Study
pign: not reported in source
finisher pigs
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
180 micrograms/kg/day · infusion · 4 daysAs given in this study (pig).
Source sentences
Summary
A four-day infusion of Long [R3] IGF-I (LR3IGF-I; 180 micrograms/kg/day) decreased the average daily gain, food intake, and plasma IGFBP-3, IGF-I and insulin concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
This study was designed to determine the effect of IGF peptides alone or in combination with porcine GH (pGH) on growth characteristics and plasma hormone concentrations in finisher pigs.
Report a problemFND-0948800104
05AnimalAnimal study (in vivo)Mechanism
In finisher pigs, a four-day infusion of LR3IGF-I decreased plasma insulin.
In plain wordsIn pigs, a four-day LR3IGF-I infusion lowered blood insulin.
Peptide
IGF-1 LR3
Outcome
DecreasePlasma insulin
Study
pign: not reported in source
finisher pigs
Outcome group
Glycemic control · Endocrine and hormones
Studied dose
180 micrograms/kg/day · infusion · 4 daysAs given in this study (pig).
Source sentences
Summary
A four-day infusion of Long [R3] IGF-I (LR3IGF-I; 180 micrograms/kg/day) decreased the average daily gain, food intake, and plasma IGFBP-3, IGF-I and insulin concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
This study was designed to determine the effect of IGF peptides alone or in combination with porcine GH (pGH) on growth characteristics and plasma hormone concentrations in finisher pigs.
Report a problemFND-0948800105
06AnimalAnimal study (in vivo)Mechanism
In finisher pigs, LR3IGF-I infusion decreased the mean plasma GH concentration by 23%.
In plain wordsIn pigs, LR3IGF-I infusion lowered average blood growth hormone by 23%.
Peptide
IGF-1 LR3
Outcome
DecreaseMean plasma GH concentration
Study
pign: not reported in source
finisher pigs
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
180 micrograms/kg/day · infusion · 4 daysAs given in this study (pig).
Measurements
Mean plasma GH decrease
23%
LR3IGF-I
Source sentences
Summary
The mean plasma GH concentration was decreased by 23%
1 context sentence(design, population, supporting numbers)
Summary · context
This study was designed to determine the effect of IGF peptides alone or in combination with porcine GH (pGH) on growth characteristics and plasma hormone concentrations in finisher pigs.
Report a problemFND-0948800106
07AnimalAnimal study (in vivo)Mechanism
In finisher pigs, LR3IGF-I infusion reduced the area under the GH peaks by 60%.
In plain wordsIn pigs, LR3IGF-I infusion reduced the size of growth hormone peaks by 60%.
Peptide
IGF-1 LR3
Outcome
DecreaseArea under the GH peaks
Study
pign: not reported in source
finisher pigs
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
180 micrograms/kg/day · infusion · 4 daysAs given in this study (pig).
Measurements
Area under GH peaks reduction
60%
LR3IGF-I
Source sentences
Summary
the area under the GH peaks was reduced by 60%.
1 context sentence(design, population, supporting numbers)
Summary · context
This study was designed to determine the effect of IGF peptides alone or in combination with porcine GH (pGH) on growth characteristics and plasma hormone concentrations in finisher pigs.
Report a problemFND-0948800107
08AnimalAnimal study (in vivo)Efficacy outcome
In finisher pigs, plasma glucose was unaffected by any treatment, including LR3IGF-I.
In plain wordsIn pigs, blood glucose did not change with any treatment, including LR3IGF-I.
Peptide
IGF-1 LR3
Outcome
No significant changePlasma glucose
Study
pign: not reported in source
finisher pigs
Outcome group
Glycemic control · Metabolic and weight
Studied dose
180 micrograms/kg/day · infusion · 4 daysAs given in this study (pig).
Source sentences
Summary
Plasma glucose levels were unaffected by any treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
This study was designed to determine the effect of IGF peptides alone or in combination with porcine GH (pGH) on growth characteristics and plasma hormone concentrations in finisher pigs.
Report a problemFND-0948800108

Studies that did not test the peptide alone5

In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 LR3.

09AnimalNot a test of IGF-1 LR3 aloneAnimal study (in vivo)Efficacy outcome
In finisher pigs, co-administration of pGH with LR3IGF-I had no interactive effect on growth performance.
In plain wordsIn pigs, adding growth hormone to LR3IGF-I made no extra difference to growth performance.
Peptide
IGF-1 LR3
Outcome
No significant changeGrowth performance with LR3IGF-I plus pGH
Study
pign: not reported in source
finisher pigs
Outcome group
Body weight · Metabolic and weight
Source sentences
Summary
Co-administration of pGH (30 micrograms/kg/day) with LR3IGF-I had no interactive effect on growth performance, and plasma insulin, IGFBP-3 and IGF-I concentrations remained suppressed.
1 context sentence(design, population, supporting numbers)
Summary · context
This study was designed to determine the effect of IGF peptides alone or in combination with porcine GH (pGH) on growth characteristics and plasma hormone concentrations in finisher pigs.
In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.
Report a problemFND-0948800109
10AnimalNot a test of IGF-1 LR3 aloneAnimal study (in vivo)Mechanism
In finisher pigs given LR3IGF-I with pGH, plasma insulin remained suppressed.
In plain wordsIn pigs given LR3IGF-I with growth hormone, blood insulin stayed low.
Peptide
IGF-1 LR3
Outcome
DecreasePlasma insulin with LR3IGF-I plus pGH
Study
pign: not reported in source
finisher pigs
Outcome group
Glycemic control · Endocrine and hormones
Source sentences
Summary
Co-administration of pGH (30 micrograms/kg/day) with LR3IGF-I had no interactive effect on growth performance, and plasma insulin, IGFBP-3 and IGF-I concentrations remained suppressed.
1 context sentence(design, population, supporting numbers)
Summary · context
This study was designed to determine the effect of IGF peptides alone or in combination with porcine GH (pGH) on growth characteristics and plasma hormone concentrations in finisher pigs.
In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.
Report a problemFND-0948800110
11AnimalNot a test of IGF-1 LR3 aloneAnimal study (in vivo)Mechanism
In finisher pigs given LR3IGF-I with pGH, plasma IGFBP-3 remained suppressed.
In plain wordsIn pigs given LR3IGF-I with growth hormone, blood IGFBP-3 stayed low.
Peptide
IGF-1 LR3
Outcome
DecreasePlasma IGFBP-3 with LR3IGF-I plus pGH
Study
pign: not reported in source
finisher pigs
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Co-administration of pGH (30 micrograms/kg/day) with LR3IGF-I had no interactive effect on growth performance, and plasma insulin, IGFBP-3 and IGF-I concentrations remained suppressed.
1 context sentence(design, population, supporting numbers)
Summary · context
This study was designed to determine the effect of IGF peptides alone or in combination with porcine GH (pGH) on growth characteristics and plasma hormone concentrations in finisher pigs.
In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.
Report a problemFND-0948800111
12AnimalNot a test of IGF-1 LR3 aloneAnimal study (in vivo)Mechanism
In finisher pigs given LR3IGF-I with pGH, plasma IGF-I remained suppressed.
In plain wordsIn pigs given LR3IGF-I with growth hormone, blood IGF-I stayed low.
Peptide
IGF-1 LR3
Outcome
DecreasePlasma IGF-I with LR3IGF-I plus pGH
Study
pign: not reported in source
finisher pigs
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Co-administration of pGH (30 micrograms/kg/day) with LR3IGF-I had no interactive effect on growth performance, and plasma insulin, IGFBP-3 and IGF-I concentrations remained suppressed.
1 context sentence(design, population, supporting numbers)
Summary · context
This study was designed to determine the effect of IGF peptides alone or in combination with porcine GH (pGH) on growth characteristics and plasma hormone concentrations in finisher pigs.
In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.
Report a problemFND-0948800112
13AnimalNot a test of IGF-1 LR3 aloneAnimal study (in vivo)Mechanism
In finisher pigs, the area under the GH peaks was not restored by the combination of LR3IGF-I and pGH.
In plain wordsIn pigs, adding growth hormone to LR3IGF-I did not restore the size of growth hormone peaks.
Peptide
IGF-1 LR3
Outcome
No significant changeArea under the GH peaks with LR3IGF-I plus pGH
Study
pign: not reported in source
finisher pigs
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
The area under the GH peaks was not restored with this combination treatment although mean plasma GH concentrations were elevated in all animals receiving pGH.
1 context sentence(design, population, supporting numbers)
Summary · context
This study was designed to determine the effect of IGF peptides alone or in combination with porcine GH (pGH) on growth characteristics and plasma hormone concentrations in finisher pigs.
In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.
Report a problemFND-0948800113

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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