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Study · Animal study (in vivo) · rat · 1997

2 results

[The effect of the delta sleep-inducing peptide on NMDA-induced seizure activity in rats].

Shandra AA, Godlevskiĭ LS, Brusentsov AI, Karliuga VA

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova1 Sept 1997

PMID9487065 (opens in a new tab)PepBankPUB-09487065
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, delta sleep-inducing peptide raised the ED100 of NMDA for clonic seizures 2.3-fold.

    In plain wordsIn rats, delta sleep-inducing peptide raised the NMDA dose needed to cause clonic seizures 2.3-fold.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseNMDA ED100 for clonic seizures
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Fold change in NMDA ED100, clonic seizures
    2.3 fold
    delta sleep-inducing peptide

    Source sentences

    Summary
    The ED100 of the NMDA inducing clonic seizures (0.53 mcg) or tonic extension of forelimbs (5.02 mcg) increased their efficiency 2.3-fold and 4.46-fold, resp., due to the delta-sleep-inducing peptide administration in rats.
    1 context sentence
    Summary · context
    The data obtained suggests a neuroprotective effect of the peptide on agonists of excitatory amino acid receptors action.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, delta sleep-inducing peptide raised the ED100 of NMDA for tonic extension of forelimbs 4.46-fold.

    In plain wordsIn rats, delta sleep-inducing peptide raised the NMDA dose needed to cause tonic forelimb extension 4.46-fold.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseNMDA ED100 for tonic extension of forelimbs
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Fold change in NMDA ED100, tonic extension
    4.46 fold
    delta sleep-inducing peptide

    Source sentences

    Summary
    The ED100 of the NMDA inducing clonic seizures (0.53 mcg) or tonic extension of forelimbs (5.02 mcg) increased their efficiency 2.3-fold and 4.46-fold, resp., due to the delta-sleep-inducing peptide administration in rats.
    1 context sentence
    Summary · context
    The data obtained suggests a neuroprotective effect of the peptide on agonists of excitatory amino acid receptors action.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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