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Study · Animal study (in vivo) · rat · 1997

3 results

[Dipeptide nootropic agent GVS-111 prevents accumulation of the lipid peroxidation products during immobilization].

Lysenko AV, Uskova NI, Ostrovskaia RU, Gudasheva TA, Voronina TA

Eksperimental'naia i klinicheskaia farmakologiia1 Sept 1997Cited by 2 (Europe PMC)

PMID9483398 (opens in a new tab)PepBankPUB-09483398
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In immobilized rats, GVS-111 reduced brain diene conjugate accumulation, particularly when given 60 min before immobilization.

    In plain wordsIn rats, GVS-111 reduced brain diene conjugate accumulation during immobilization.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseCortical synaptosomal diene conjugates
    Study

    ratn: not reported in source

    24 h immobilization
    Outcome group
    Oxidative stress · Nervous system and cognition
    Studied dose
    0.12 and 0.5 mg/kg · intraperitoneal · Single injection 15 or 60 min before immobilizationAs given in this study (rat).

    Source sentences

    Summary
    The dipeptide nootropic agent GVS-111 (ethyl ether of phenylacetylprolylglycine), when administered 15 and particularly 60 min before immobilization reduced the accumulation of these products of lipid peroxidation in the brain and blood.
    2 context sentences
    Summary · context
    Immobilization of rats in a narrow plastic chamber for 24 h caused a sharp increase in the level of diene conjugates and the content of schiff bases in the synaptosomes of the brain cortex as well as accumulation of extraerythrocytic hemoglobin in blood serum.
    Summary · context
    GVS-111 demonstrated these signs of its antioxidant effect after a single i.p. injection in doses of 0.12 and 0.5 mg/kg.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In immobilized rats, GVS-111 reduced brain Schiff base accumulation, particularly when given 60 min before immobilization.

    In plain wordsIn rats, GVS-111 reduced brain Schiff base accumulation during immobilization.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseCortical synaptosomal Schiff bases
    Study

    ratn: not reported in source

    24 h immobilization
    Outcome group
    Oxidative stress · Nervous system and cognition
    Studied dose
    0.12 and 0.5 mg/kg · intraperitoneal · Single injection 15 or 60 min before immobilizationAs given in this study (rat).

    Source sentences

    Summary
    The dipeptide nootropic agent GVS-111 (ethyl ether of phenylacetylprolylglycine), when administered 15 and particularly 60 min before immobilization reduced the accumulation of these products of lipid peroxidation in the brain and blood.
    2 context sentences
    Summary · context
    Immobilization of rats in a narrow plastic chamber for 24 h caused a sharp increase in the level of diene conjugates and the content of schiff bases in the synaptosomes of the brain cortex as well as accumulation of extraerythrocytic hemoglobin in blood serum.
    Summary · context
    GVS-111 demonstrated these signs of its antioxidant effect after a single i.p. injection in doses of 0.12 and 0.5 mg/kg.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In immobilized rats, GVS-111 reduced serum extraerythrocytic hemoglobin accumulation, particularly when given 60 min before immobilization.

    In plain wordsIn rats, GVS-111 reduced serum hemoglobin accumulation outside red blood cells during immobilization.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseSerum extraerythrocytic hemoglobin
    Study

    ratn: not reported in source

    24 h immobilization
    Outcome group
    Oxidative stress · Whole body
    Studied dose
    0.12 and 0.5 mg/kg · intraperitoneal · Single injection 15 or 60 min before immobilizationAs given in this study (rat).

    Source sentences

    Summary
    The dipeptide nootropic agent GVS-111 (ethyl ether of phenylacetylprolylglycine), when administered 15 and particularly 60 min before immobilization reduced the accumulation of these products of lipid peroxidation in the brain and blood.
    2 context sentences
    Summary · context
    Immobilization of rats in a narrow plastic chamber for 24 h caused a sharp increase in the level of diene conjugates and the content of schiff bases in the synaptosomes of the brain cortex as well as accumulation of extraerythrocytic hemoglobin in blood serum.
    Summary · context
    GVS-111 demonstrated these signs of its antioxidant effect after a single i.p. injection in doses of 0.12 and 0.5 mg/kg.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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