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Study · Animal study (in vivo) · cattle · 1998

9 results

Endocrine and metabolic changes in neonatal calves in response to growth hormone and long-R3-insulin-like growth factor-I administration.

Hammon H, Blum JW

Biology of the neonate1 Jan 1998Cited by 9 (Europe PMC)

PMID9483305 (opens in a new tab)DOI10.1159/000013968 (opens in a new tab)PepBankPUB-09483305
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal calves, subcutaneous Long-R3-IGF-I lowered plasma glucose.

    In plain wordsIn calves, an injected IGF-I analogue lowered blood glucose.

    Peptide
    IGF-1 LR3
    Outcome
    DecreasePlasma glucose
    Study

    cattlen: not reported in source

    Neonatal calves
    Comparator
    Control (colostrum then milk replacer)
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    50 micrograms/[kg x day], twice daily · subcutaneous · 7 daysAs given in this study (cattle).

    Source sentences

    Summary
    subcutaneously administered Long-R3-IGF-I lowered plasma glucose and insulin concentrations (p < 0.05).
    2 context sentences
    Summary · context
    We have studied effects of recombinant bovine GH (rbGH) and Long-R3-insulin-like growth factor-I (Long-R3-IGF-I) on metabolic and endocrine characteristics of neonatal calves.
    Summary · context
    In group GrIGFf, Long-R3-IGF-I (50 micrograms/[kg x day], twice daily for 7 days) was fed together with colostrum or milk replacer and in group GrIGFi, Long-R3-IGF-I (50 micrograms/[kg x day], twice daily for 7 days) was injected subcutaneously at times of feeding.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal calves, subcutaneous Long-R3-IGF-I lowered plasma insulin concentrations.

    In plain wordsIn calves, an injected IGF-I analogue lowered blood insulin.

    Peptide
    IGF-1 LR3
    Outcome
    DecreasePlasma insulin
    Study

    cattlen: not reported in source

    Neonatal calves
    Comparator
    Control (colostrum then milk replacer)
    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    50 micrograms/[kg x day], twice daily · subcutaneous · 7 daysAs given in this study (cattle).

    Source sentences

    Summary
    subcutaneously administered Long-R3-IGF-I lowered plasma glucose and insulin concentrations (p < 0.05).
    2 context sentences
    Summary · context
    We have studied effects of recombinant bovine GH (rbGH) and Long-R3-insulin-like growth factor-I (Long-R3-IGF-I) on metabolic and endocrine characteristics of neonatal calves.
    Summary · context
    In group GrIGFf, Long-R3-IGF-I (50 micrograms/[kg x day], twice daily for 7 days) was fed together with colostrum or milk replacer and in group GrIGFi, Long-R3-IGF-I (50 micrograms/[kg x day], twice daily for 7 days) was injected subcutaneously at times of feeding.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal calves, orally administered Long-R3-IGF-I had no effects on the measured metabolic and endocrine traits.

    In plain wordsIn calves, an IGF-I analogue given by mouth had no effects on the measured traits.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeMetabolic and endocrine measures with oral administration
    Study

    cattlen: not reported in source

    Neonatal calves
    Comparator
    Control (colostrum then milk replacer)
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    50 micrograms/[kg x day], twice daily · oral (fed with colostrum or milk replacer) · 7 daysAs given in this study (cattle).

    Source sentences

    Summary
    While orally administered Long-R3-IGF-I had no effects
    2 context sentences
    Summary · context
    We have studied effects of recombinant bovine GH (rbGH) and Long-R3-insulin-like growth factor-I (Long-R3-IGF-I) on metabolic and endocrine characteristics of neonatal calves.
    Summary · context
    In group GrIGFf, Long-R3-IGF-I (50 micrograms/[kg x day], twice daily for 7 days) was fed together with colostrum or milk replacer and in group GrIGFi, Long-R3-IGF-I (50 micrograms/[kg x day], twice daily for 7 days) was injected subcutaneously at times of feeding.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal calves, Long-R3-IGF-I did not significantly affect plasma lactic acid.

    In plain wordsIn calves, an IGF-I analogue did not significantly change blood lactic acid.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changePlasma lactic acid
    Study

    cattlen: not reported in source

    Neonatal calves
    Comparator
    Control (colostrum then milk replacer)
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    50 micrograms/[kg x day], twice daily · 7 daysAs given in this study (cattle).

    Source sentences

    Summary
    Other traits (lactic acid, nonesterified fatty acids, glucagon, cortisol, thyroxine and 3.5.3'-triiodothyronine) exhibited age-dependent changes, but were not significantly affected by rbGH or Long-R3-IGF-I.
    2 context sentences
    Summary · context
    We have studied effects of recombinant bovine GH (rbGH) and Long-R3-insulin-like growth factor-I (Long-R3-IGF-I) on metabolic and endocrine characteristics of neonatal calves.
    Summary · context
    In group GrIGFf, Long-R3-IGF-I (50 micrograms/[kg x day], twice daily for 7 days) was fed together with colostrum or milk replacer and in group GrIGFi, Long-R3-IGF-I (50 micrograms/[kg x day], twice daily for 7 days) was injected subcutaneously at times of feeding.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal calves, Long-R3-IGF-I did not significantly affect plasma nonesterified fatty acids.

    In plain wordsIn calves, an IGF-I analogue did not significantly change blood fatty acids.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changePlasma nonesterified fatty acids
    Study

    cattlen: not reported in source

    Neonatal calves
    Comparator
    Control (colostrum then milk replacer)
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    50 micrograms/[kg x day], twice daily · 7 daysAs given in this study (cattle).

    Source sentences

    Summary
    Other traits (lactic acid, nonesterified fatty acids, glucagon, cortisol, thyroxine and 3.5.3'-triiodothyronine) exhibited age-dependent changes, but were not significantly affected by rbGH or Long-R3-IGF-I.
    2 context sentences
    Summary · context
    We have studied effects of recombinant bovine GH (rbGH) and Long-R3-insulin-like growth factor-I (Long-R3-IGF-I) on metabolic and endocrine characteristics of neonatal calves.
    Summary · context
    In group GrIGFf, Long-R3-IGF-I (50 micrograms/[kg x day], twice daily for 7 days) was fed together with colostrum or milk replacer and in group GrIGFi, Long-R3-IGF-I (50 micrograms/[kg x day], twice daily for 7 days) was injected subcutaneously at times of feeding.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal calves, Long-R3-IGF-I did not significantly affect plasma glucagon.

    In plain wordsIn calves, an IGF-I analogue did not significantly change blood glucagon.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changePlasma glucagon
    Study

    cattlen: not reported in source

    Neonatal calves
    Comparator
    Control (colostrum then milk replacer)
    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    50 micrograms/[kg x day], twice daily · 7 daysAs given in this study (cattle).

    Source sentences

    Summary
    Other traits (lactic acid, nonesterified fatty acids, glucagon, cortisol, thyroxine and 3.5.3'-triiodothyronine) exhibited age-dependent changes, but were not significantly affected by rbGH or Long-R3-IGF-I.
    2 context sentences
    Summary · context
    We have studied effects of recombinant bovine GH (rbGH) and Long-R3-insulin-like growth factor-I (Long-R3-IGF-I) on metabolic and endocrine characteristics of neonatal calves.
    Summary · context
    In group GrIGFf, Long-R3-IGF-I (50 micrograms/[kg x day], twice daily for 7 days) was fed together with colostrum or milk replacer and in group GrIGFi, Long-R3-IGF-I (50 micrograms/[kg x day], twice daily for 7 days) was injected subcutaneously at times of feeding.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal calves, Long-R3-IGF-I did not significantly affect plasma cortisol.

    In plain wordsIn calves, an IGF-I analogue did not significantly change blood cortisol.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changePlasma cortisol
    Study

    cattlen: not reported in source

    Neonatal calves
    Comparator
    Control (colostrum then milk replacer)
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    50 micrograms/[kg x day], twice daily · 7 daysAs given in this study (cattle).

    Source sentences

    Summary
    Other traits (lactic acid, nonesterified fatty acids, glucagon, cortisol, thyroxine and 3.5.3'-triiodothyronine) exhibited age-dependent changes, but were not significantly affected by rbGH or Long-R3-IGF-I.
    2 context sentences
    Summary · context
    We have studied effects of recombinant bovine GH (rbGH) and Long-R3-insulin-like growth factor-I (Long-R3-IGF-I) on metabolic and endocrine characteristics of neonatal calves.
    Summary · context
    In group GrIGFf, Long-R3-IGF-I (50 micrograms/[kg x day], twice daily for 7 days) was fed together with colostrum or milk replacer and in group GrIGFi, Long-R3-IGF-I (50 micrograms/[kg x day], twice daily for 7 days) was injected subcutaneously at times of feeding.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal calves, Long-R3-IGF-I did not significantly affect plasma thyroxine.

    In plain wordsIn calves, an IGF-I analogue did not significantly change blood thyroxine.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changePlasma thyroxine
    Study

    cattlen: not reported in source

    Neonatal calves
    Comparator
    Control (colostrum then milk replacer)
    Outcome group
    Thyroid function · Endocrine and hormones
    Studied dose
    50 micrograms/[kg x day], twice daily · 7 daysAs given in this study (cattle).

    Source sentences

    Summary
    Other traits (lactic acid, nonesterified fatty acids, glucagon, cortisol, thyroxine and 3.5.3'-triiodothyronine) exhibited age-dependent changes, but were not significantly affected by rbGH or Long-R3-IGF-I.
    2 context sentences
    Summary · context
    We have studied effects of recombinant bovine GH (rbGH) and Long-R3-insulin-like growth factor-I (Long-R3-IGF-I) on metabolic and endocrine characteristics of neonatal calves.
    Summary · context
    In group GrIGFf, Long-R3-IGF-I (50 micrograms/[kg x day], twice daily for 7 days) was fed together with colostrum or milk replacer and in group GrIGFi, Long-R3-IGF-I (50 micrograms/[kg x day], twice daily for 7 days) was injected subcutaneously at times of feeding.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal calves, Long-R3-IGF-I did not significantly affect plasma 3,5,3'-triiodothyronine.

    In plain wordsIn calves, an IGF-I analogue did not significantly change blood triiodothyronine.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changePlasma 3,5,3'-triiodothyronine
    Study

    cattlen: not reported in source

    Neonatal calves
    Comparator
    Control (colostrum then milk replacer)
    Outcome group
    Thyroid function · Endocrine and hormones
    Studied dose
    50 micrograms/[kg x day], twice daily · 7 daysAs given in this study (cattle).

    Source sentences

    Summary
    Other traits (lactic acid, nonesterified fatty acids, glucagon, cortisol, thyroxine and 3.5.3'-triiodothyronine) exhibited age-dependent changes, but were not significantly affected by rbGH or Long-R3-IGF-I.
    2 context sentences
    Summary · context
    We have studied effects of recombinant bovine GH (rbGH) and Long-R3-insulin-like growth factor-I (Long-R3-IGF-I) on metabolic and endocrine characteristics of neonatal calves.
    Summary · context
    In group GrIGFf, Long-R3-IGF-I (50 micrograms/[kg x day], twice daily for 7 days) was fed together with colostrum or milk replacer and in group GrIGFi, Long-R3-IGF-I (50 micrograms/[kg x day], twice daily for 7 days) was injected subcutaneously at times of feeding.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

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