A prospective randomized study to evaluate leuprolide acetate treatment before laparoscopic myomectomy: efficacy and ultrasonographic predictors.

Zullo F, Zullo F, Pellicano M, De Stefano R, Zupi E, Mastrantonio P

American journal of obstetrics and gynecology1 Jan 1998Cited by 55 (Europe PMC)

PMID9465812DOI10.1016/s0002-9378(98)70635-0PepBankPUB-09465812

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

01HumanRandomized controlled trialEfficacy outcome
In women undergoing myomectomy, postoperative red blood cell counts were significantly higher with leuprolide pretreatment than direct surgery.
In plain wordsIn women undergoing fibroid surgery, red blood cell counts after surgery were higher with leuprolide pretreatment than direct surgery.
Peptide
Leuprolide
Outcome
IncreasePostoperative red blood cell count
Study
n = 67
Comparator
Direct surgery without leuprolide pretreatment
Outcome group
Bleeding and clotting · Reproductive and sexual health
Studied dose
Two depot injections 28 days apart · injectionAs given in this study (human).
Source sentences
Summary
Postoperatively, the red blood cell count and the serum hemoglobin and iron levels were significantly (p < 0.05) lower in group B.
2 context sentences(design, population, supporting numbers)
Summary · context
A prospective randomized study was performed on 67 patients with symptomatic uterine fibroids that were mainly intramural; these patients were undergoing laparoscopic myomectomy.
Summary · context
Patients were randomized either to preoperative administration of two injections of a depot formulation of leuprolide acetate 28 days apart (group A, n = 35) or to direct surgery (group B, n = 32).
Report a problemFND-0946581201
02HumanRandomized controlled trialEfficacy outcome
In women undergoing myomectomy, postoperative hemoglobin was significantly higher with leuprolide pretreatment than direct surgery.
In plain wordsIn women undergoing fibroid surgery, hemoglobin after surgery was higher with leuprolide pretreatment than direct surgery.
Peptide
Leuprolide
Outcome
IncreasePostoperative hemoglobin
Study
n = 67
Comparator
Direct surgery without leuprolide pretreatment
Outcome group
Bleeding and clotting · Reproductive and sexual health
Studied dose
Two depot injections 28 days apart · injectionAs given in this study (human).
Source sentences
Summary
Postoperatively, the red blood cell count and the serum hemoglobin and iron levels were significantly (p < 0.05) lower in group B.
2 context sentences(design, population, supporting numbers)
Summary · context
A prospective randomized study was performed on 67 patients with symptomatic uterine fibroids that were mainly intramural; these patients were undergoing laparoscopic myomectomy.
Summary · context
Patients were randomized either to preoperative administration of two injections of a depot formulation of leuprolide acetate 28 days apart (group A, n = 35) or to direct surgery (group B, n = 32).
Report a problemFND-0946581202
03HumanRandomized controlled trialEfficacy outcome
In women undergoing myomectomy, postoperative serum iron was significantly higher with leuprolide pretreatment than direct surgery.
In plain wordsIn women undergoing fibroid surgery, serum iron after surgery was higher with leuprolide pretreatment than direct surgery.
Peptide
Leuprolide
Outcome
IncreasePostoperative serum iron
Study
n = 67
Comparator
Direct surgery without leuprolide pretreatment
Outcome group
Bleeding and clotting · Reproductive and sexual health
Studied dose
Two depot injections 28 days apart · injectionAs given in this study (human).
Source sentences
Summary
Postoperatively, the red blood cell count and the serum hemoglobin and iron levels were significantly (p < 0.05) lower in group B.
2 context sentences(design, population, supporting numbers)
Summary · context
A prospective randomized study was performed on 67 patients with symptomatic uterine fibroids that were mainly intramural; these patients were undergoing laparoscopic myomectomy.
Summary · context
Patients were randomized either to preoperative administration of two injections of a depot formulation of leuprolide acetate 28 days apart (group A, n = 35) or to direct surgery (group B, n = 32).
Report a problemFND-0946581203
04HumanRandomized controlled trialEfficacy outcome
In women undergoing myomectomy, leuprolide pretreatment reduced operative blood loss compared with direct surgery (p < 0.01).
In plain wordsIn women undergoing fibroid surgery, leuprolide pretreatment reduced blood loss compared with direct surgery.
Peptide
Leuprolide
Outcome
DecreaseOperative blood loss
Study
n = 67
Comparator
Direct surgery without leuprolide pretreatment
Outcome group
Bleeding and clotting · Reproductive and sexual health
Studied dose
Two depot injections 28 days apart · injectionAs given in this study (human).
Source sentences
Summary
Both blood loss (p < 0.01) and operative time (p < 0.05) were significantly lower in group A.
2 context sentences(design, population, supporting numbers)
Summary · context
A prospective randomized study was performed on 67 patients with symptomatic uterine fibroids that were mainly intramural; these patients were undergoing laparoscopic myomectomy.
Summary · context
Patients were randomized either to preoperative administration of two injections of a depot formulation of leuprolide acetate 28 days apart (group A, n = 35) or to direct surgery (group B, n = 32).
Report a problemFND-0946581204
05HumanRandomized controlled trialEfficacy outcome
In women undergoing myomectomy, leuprolide pretreatment reduced operative time compared with direct surgery (p < 0.05).
In plain wordsIn women undergoing fibroid surgery, leuprolide pretreatment reduced surgery time compared with direct surgery.
Peptide
Leuprolide
Outcome
DecreaseOperative time
Study
n = 67
Comparator
Direct surgery without leuprolide pretreatment
Outcome group
Operative time · Reproductive and sexual health
Studied dose
Two depot injections 28 days apart · injectionAs given in this study (human).
Source sentences
Summary
Both blood loss (p < 0.01) and operative time (p < 0.05) were significantly lower in group A.
2 context sentences(design, population, supporting numbers)
Summary · context
A prospective randomized study was performed on 67 patients with symptomatic uterine fibroids that were mainly intramural; these patients were undergoing laparoscopic myomectomy.
Summary · context
Patients were randomized either to preoperative administration of two injections of a depot formulation of leuprolide acetate 28 days apart (group A, n = 35) or to direct surgery (group B, n = 32).
Report a problemFND-0946581205
06HumanObservational studyEfficacy outcome
In women receiving leuprolide before myomectomy, markedly hypoechoic main fibroids were linked to longer operative time.
In plain wordsIn women receiving leuprolide before fibroid surgery, markedly hypoechoic fibroids were linked to longer surgery.
Peptide
Leuprolide
Outcome
IncreaseOperative time with hypoechoic fibroids
Study
n: not reported in source
Comparator
Fibroids without marked hypoechogenicity
Outcome group
Operative time · Reproductive and sexual health
Studied dose
Two depot injections 28 days apart · injectionAs given in this study (human).
Source sentences
Summary
However, the operative time was significantly longer when the main fibroid was markedly hypoechoic, probably because the increased softness of the tumor after leuprolide acetate pretreatment makes its enucleation much more cumbersome.
2 context sentences(design, population, supporting numbers)
Summary · context
A prospective randomized study was performed on 67 patients with symptomatic uterine fibroids that were mainly intramural; these patients were undergoing laparoscopic myomectomy.
Summary · context
Patients were randomized either to preoperative administration of two injections of a depot formulation of leuprolide acetate 28 days apart (group A, n = 35) or to direct surgery (group B, n = 32).
Report a problemFND-0946581206

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:37 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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