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Study · Animal study (in vivo) · rat · 1997

2 results

[The correction of amphetamine action by the delta sleep-inducing peptide].

Dovedova EL, Monakov MIu

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 1997

PMID9463038 (opens in a new tab)PepBankPUB-09463038
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats given amphetamine, delta sleep-inducing peptide normalized the enzyme activities of neurotransmitter turnover and the biogenic amine contents in motor cortex and caudate nucleus.

    In plain wordsIn rats given amphetamine, delta sleep-inducing peptide returned brain neurotransmitter measures toward normal.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    MixedNeurotransmitter turnover enzymes and biogenic amines in motor cortex and caudate nucleus
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    60 micrograms/kgAs given in this study (rat).

    Source sentences

    Summary
    Normalizing action of the peptide on the studied indices was found.
    2 context sentences
    Summary · context
    Activities of the enzymes of neurotransmitter turnover as well as the contents of biogenic amines in structures of motor cortex and caudate nucleus were investigated.
    Summary · context
    Effects of "delta-sleep inducing peptide" administration (60 micrograms/kg) to rats on the background of amphetamine action (2.5 mg/kg during 3 weeks) were studied.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats given amphetamine, delta sleep-inducing peptide corrected the amphetamine-induced increase in dopaminergic and serotoninergic system activity.

    In plain wordsIn rats given amphetamine, delta sleep-inducing peptide corrected the raised activity of dopamine and serotonin systems.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseDopaminergic and serotoninergic system activity after amphetamine
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    60 micrograms/kgAs given in this study (rat).

    Source sentences

    Summary
    It reflected the correction of the increased activity of dopaminergic and serotoninergic systems elevated as a result of amphetamine action.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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