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Study · Not a test of the peptide alone · 1998

2 results

Conformational changes of neuromedin B and delta sleep-inducing peptide induced by their interaction with lipid membranes as revealed by spectroscopic techniques and molecular dynamics simulation.

Polverini E, Casadio R, Neyroz P, Masotti L

Archives of biochemistry and biophysics1 Jan 1998Cited by 8 (Europe PMC)

PMID9448709 (opens in a new tab)DOI10.1006/abbi.1997.0395 (opens in a new tab)PepBankPUB-09448709
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

  1. 01LabNot a test of Delta sleep-inducing peptide (DSIP) aloneIn vitro (cell-free)Mechanism

    In a lipid environment, the fluorescence parameters of DSIP were negligibly affected compared with aqueous buffer.

    In plain wordsIn lab tests, DSIP's fluorescence barely changed in a lipid environment compared with water-based buffer.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeFluorescence of DSIP in lipid environment versus aqueous buffer
    Study

    n: not reported in source

    Lipid membrane model studied by fluorescence, circular dichroism and molecular dynamics
    Comparator
    Aqueous buffer
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    On the other hand, in the lipid environment the same parameters of DSIP are negligibly affected as compared to the aqueous buffer.
    1 context sentence
    Summary · context
    Static and dynamic spectroscopic properties of the tryptophanil emission in conjunction with circular dichroism (CD) spectroscopy and molecular dynamics are used to investigate the interactions of the neuropeptide neuromedin B (NMB) and the membrane-permeable delta sleep-inducing peptide (DSIP) with…

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  2. 02LabNot a test of Delta sleep-inducing peptide (DSIP) aloneIn vitro (cell-free)Mechanism

    Circular dichroism and molecular dynamics indicated that DSIP adopts a globule-like structure with a surface-exposed indole ring.

    In plain wordsIn lab tests, DSIP took a globule-like shape with its indole ring exposed on the surface.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableDSIP conformation in lipid environment
    Study

    n: not reported in source

    Lipid membrane model studied by fluorescence, circular dichroism and molecular dynamics
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    while NMB assumes a helix-like conformation with the tryptophan residue in the apolar surface, DSIP adopts a globule-like structure with the indole ring that is surface-exposed
    1 context sentence
    Summary · context
    Static and dynamic spectroscopic properties of the tryptophanil emission in conjunction with circular dichroism (CD) spectroscopy and molecular dynamics are used to investigate the interactions of the neuropeptide neuromedin B (NMB) and the membrane-permeable delta sleep-inducing peptide (DSIP) with…

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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