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Study · In vitro (cells) · bovine · 1997

2 results

Insulin-like growth factor binding protein production in bovine retinal endothelial cells.

Giannini S, Cresci B, Manuelli C, Fujita-Yamaguchi Y, Romagnani P, Mohan S, Rotella CM

Metabolism: clinical and experimental1 Dec 1997Cited by 12 (Europe PMC)

PMID9439529 (opens in a new tab)DOI10.1016/s0026-0495(97)90134-7 (opens in a new tab)PepBankPUB-09439529
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In bovine retinal endothelial cells, Des(1‑3)IGF-I did not modulate IGFBPs.

    In plain wordsIn cells from bovine retinas, Des(1‑3)IGF-I did not change IGFBPs.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeIGFBP modulation
    Study

    bovinen: not reported in source

    Bovine retinal endothelial cells
    Outcome group
    Receptor activity and mechanism · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Des(1-3)IGF-I had no effect on IGFBP modulation
    1 context sentence
    Summary · context
    Bovine retinal endothelial cells (BRECs) were cultured to investigate if insulin, insulin-like growth factors (IGFs), IGF binding proteins (IGFBPs), and a chronic high-glucose condition could control endothelial cell growth.
  2. 02LabIn vitro (cells)Activity measurement

    In bovine retinal endothelial cells, Des(1‑3)IGF-I enhanced thymidine incorporation and significantly stimulated growth only at 10 nmol/L.

    In plain wordsIn cells from bovine retinas, Des(1‑3)IGF-I increased thymidine incorporation and stimulated growth only at 10 nmol/L.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseThymidine incorporation
    Study

    bovinen: not reported in source

    Bovine retinal endothelial cells
    Outcome group
    Receptor activity and mechanism · Eye
    Studied dose
    10 nmol/LAs given in this study (bovine).

    Source sentences

    Summary
    Des(1-3)IGF-I had no effect on IGFBP modulation, whereas at 10 nmol/L it enhanced BREC thymidine cell incorporation
    2 context sentences
    Summary · context
    the IGF-I analog, Des(1-3), even with reduced affinity for IGFBPs but in part capable of binding to IGFBP-3, significantly stimulated BRECs growth only at 10 nmol/L.
    Summary · context
    Bovine retinal endothelial cells (BRECs) were cultured to investigate if insulin, insulin-like growth factors (IGFs), IGF binding proteins (IGFBPs), and a chronic high-glucose condition could control endothelial cell growth.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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