Intestinal response to growth factors administered alone or in combination with human [Gly2]glucagon-like peptide 2.

Drucker DJ, DeForest L, Brubaker PL

The American journal of physiology1 Dec 1997Cited by 94 (Europe PMC)

PMID9435550DOI10.1152/ajpgi.1997.273.6.g1252PepBankPUB-09435550

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 LR3.

01AnimalNot a test of IGF-1 LR3 aloneAnimal study (in vivo)Efficacy outcome
In mice, administration of five growth factors together (h[Gly2]GLP-2, EGF, LR3IGF-I, [Gly1]IGF-II and hGH) increased crypt plus villus height.
In plain wordsIn mice, giving five growth factors together increased the height of the gut lining's crypts and villi.
Peptide
IGF-1 LR3
Outcome
IncreaseCrypt plus villus height
Study
mousen: not reported in source
Outcome group
Gastrointestinal protection · Gastrointestinal
Source sentences
Summary
Administration of all five growth factors together induced significant increases in crypt plus villus height and in small and large bowel length and weight.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the intestinotrophic properties of a dipeptidyl peptidase IV resistant glucagon-like peptide 2 (GLP-2) analog, human [Gly2]GLP-2 (h[Gly2]GLP-2), as well as of epidermal growth factor (EGF), long [Arg3]insulin-like growth factor I (LR3IGF-I), [Gly1]IGF-II, and human growth hormone (hGH), a…
In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.
Report a problemFND-0943555001
02AnimalNot a test of IGF-1 LR3 aloneAnimal study (in vivo)Efficacy outcome
In mice, administration of five growth factors together (h[Gly2]GLP-2, EGF, LR3IGF-I, [Gly1]IGF-II and hGH) increased small bowel length.
In plain wordsIn mice, giving five growth factors together made the small bowel longer.
Peptide
IGF-1 LR3
Outcome
IncreaseSmall bowel length
Study
mousen: not reported in source
Outcome group
Gastrointestinal protection · Gastrointestinal
Source sentences
Summary
Administration of all five growth factors together induced significant increases in crypt plus villus height and in small and large bowel length and weight.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the intestinotrophic properties of a dipeptidyl peptidase IV resistant glucagon-like peptide 2 (GLP-2) analog, human [Gly2]GLP-2 (h[Gly2]GLP-2), as well as of epidermal growth factor (EGF), long [Arg3]insulin-like growth factor I (LR3IGF-I), [Gly1]IGF-II, and human growth hormone (hGH), a…
In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.
Report a problemFND-0943555002
03AnimalNot a test of IGF-1 LR3 aloneAnimal study (in vivo)Efficacy outcome
In mice, administration of five growth factors together (h[Gly2]GLP-2, EGF, LR3IGF-I, [Gly1]IGF-II and hGH) increased large bowel length.
In plain wordsIn mice, giving five growth factors together made the large bowel longer.
Peptide
IGF-1 LR3
Outcome
IncreaseLarge bowel length
Study
mousen: not reported in source
Outcome group
Gastrointestinal protection · Gastrointestinal
Source sentences
Summary
Administration of all five growth factors together induced significant increases in crypt plus villus height and in small and large bowel length and weight.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the intestinotrophic properties of a dipeptidyl peptidase IV resistant glucagon-like peptide 2 (GLP-2) analog, human [Gly2]GLP-2 (h[Gly2]GLP-2), as well as of epidermal growth factor (EGF), long [Arg3]insulin-like growth factor I (LR3IGF-I), [Gly1]IGF-II, and human growth hormone (hGH), a…
In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.
Report a problemFND-0943555003
04AnimalNot a test of IGF-1 LR3 aloneAnimal study (in vivo)Efficacy outcome
In mice, administration of five growth factors together (h[Gly2]GLP-2, EGF, LR3IGF-I, [Gly1]IGF-II and hGH) increased small bowel weight.
In plain wordsIn mice, giving five growth factors together increased the weight of the small bowel.
Peptide
IGF-1 LR3
Outcome
IncreaseSmall bowel weight
Study
mousen: not reported in source
Outcome group
Gastrointestinal protection · Gastrointestinal
Source sentences
Summary
Administration of all five growth factors together induced significant increases in crypt plus villus height and in small and large bowel length and weight.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the intestinotrophic properties of a dipeptidyl peptidase IV resistant glucagon-like peptide 2 (GLP-2) analog, human [Gly2]GLP-2 (h[Gly2]GLP-2), as well as of epidermal growth factor (EGF), long [Arg3]insulin-like growth factor I (LR3IGF-I), [Gly1]IGF-II, and human growth hormone (hGH), a…
In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.
Report a problemFND-0943555004
05AnimalNot a test of IGF-1 LR3 aloneAnimal study (in vivo)Efficacy outcome
In mice, administration of five growth factors together (h[Gly2]GLP-2, EGF, LR3IGF-I, [Gly1]IGF-II and hGH) increased large bowel weight.
In plain wordsIn mice, giving five growth factors together increased the weight of the large bowel.
Peptide
IGF-1 LR3
Outcome
IncreaseLarge bowel weight
Study
mousen: not reported in source
Outcome group
Gastrointestinal protection · Gastrointestinal
Source sentences
Summary
Administration of all five growth factors together induced significant increases in crypt plus villus height and in small and large bowel length and weight.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the intestinotrophic properties of a dipeptidyl peptidase IV resistant glucagon-like peptide 2 (GLP-2) analog, human [Gly2]GLP-2 (h[Gly2]GLP-2), as well as of epidermal growth factor (EGF), long [Arg3]insulin-like growth factor I (LR3IGF-I), [Gly1]IGF-II, and human growth hormone (hGH), a…
In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.
Report a problemFND-0943555005

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

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