Skip to content

Study · In vitro (cells) · 1998

9 results

Human fetal pituitary expresses functional growth hormone-releasing peptide receptors.

Shimon I, Yan X, Melmed S

The Journal of clinical endocrinology and metabolism1 Jan 1998Cited by 34 (Europe PMC)

PMID9435437 (opens in a new tab)DOI10.1210/jcem.83.1.4520 (opens in a new tab)PepBankPUB-09435437
Publisher pagePubMedAsk about this study
Jump to 9 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In human fetal pituitary cultures, GHRP‑6 dose-dependently increased GH secretion by up to 80%.

    In plain wordsIn cells from human fetal pituitary, GHRP‑6 raised growth hormone release by up to 80%.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH secretion
    Study

    humann: not reported in source

    primary human fetal pituitary cultures
    Comparator
    GHRH 10 nmol/L
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    dose-dependent, maximal effect at 100 nmol/LAs given in this study (human).

    Measurements

    GH secretion increase
    80%
    GHRP-6

    Source sentences

    Summary
    GHRP-6 dose-dependently increased GH secretion from human fetal pituitary cultures by up to 80% (P < 0.001; maximal effect achieved with 100 nmol/L), whereas GHRH (10 nmol/L) stimulated GH by up to 120% (P < 0.001).
    1 context sentence
    Summary · context
    Therefore, primary human fetal pituitary cultures (second and third trimesters) were treated with GHRP-6.
  2. 02LabIn vitro (cells)Activity measurement

    In human fetal pituitary cultures, GHRP‑6 did not alter ACTH levels.

    In plain wordsIn cells from human fetal pituitary, GHRP‑6 did not change ACTH levels.

    Peptide
    GHRP-6
    Outcome
    No significant changeACTH levels
    Study

    humann: not reported in source

    primary human fetal pituitary cultures
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast to GHRH, GHRP-6 did not alter human ACTH and PRL levels.
    1 context sentence
    Summary · context
    Therefore, primary human fetal pituitary cultures (second and third trimesters) were treated with GHRP-6.
  3. 03LabIn vitro (cells)Activity measurement

    In human fetal pituitary cultures, GHRP‑6 did not alter prolactin levels.

    In plain wordsIn cells from human fetal pituitary, GHRP‑6 did not change prolactin levels.

    Peptide
    GHRP-6
    Outcome
    No significant changeProlactin levels
    Study

    humann: not reported in source

    primary human fetal pituitary cultures
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast to GHRH, GHRP-6 did not alter human ACTH and PRL levels.
    1 context sentence
    Summary · context
    Therefore, primary human fetal pituitary cultures (second and third trimesters) were treated with GHRP-6.
  4. 04LabIn vitro (cells)Activity measurement

    In human fetal pituitary cultures, a treatment time of 2 h was required for maximal GH stimulation by GHRP‑6.

    In plain wordsIn cells from human fetal pituitary, GHRP‑6 needed about 2 hours to give its biggest growth hormone effect.

    Peptide
    GHRP-6
    Outcome
    Not applicableTreatment time for maximal GH stimulation
    Study

    humann: not reported in source

    primary human fetal pituitary cultures
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A treatment time of 2 h was required for maximal GH stimulation.
    1 context sentence
    Summary · context
    Therefore, primary human fetal pituitary cultures (second and third trimesters) were treated with GHRP-6.
  5. 05LabIn vitro (cells)Activity measurement

    In human fetal pituitary cultures, GHRP‑6 reversed GH suppression caused by IGF-I (P < 0.0001).

    In plain wordsIn cells from human fetal pituitary, GHRP‑6 reversed the drop in growth hormone caused by IGF-I.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH in cultures suppressed by IGF-I
    Study

    humann: not reported in source

    primary human fetal pituitary cultures
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHRP-6 reversed suppressed GH levels in cultures cotreated with either insulin-like growth factor I (P < 0.0001)
    1 context sentence
    Summary · context
    Therefore, primary human fetal pituitary cultures (second and third trimesters) were treated with GHRP-6.
  6. 06LabIn vitro (cells)Activity measurement

    In human fetal pituitary cultures, GHRP‑6 reversed GH suppression caused by somatostatin (P < 0.05).

    In plain wordsIn cells from human fetal pituitary, GHRP‑6 reversed the drop in growth hormone caused by somatostatin.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH in cultures suppressed by somatostatin
    Study

    humann: not reported in source

    primary human fetal pituitary cultures
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHRP-6 reversed suppressed GH levels in cultures cotreated with either insulin-like growth factor I (P < 0.0001) or somatostatin (P < 0.05).
    1 context sentence
    Summary · context
    Therefore, primary human fetal pituitary cultures (second and third trimesters) were treated with GHRP-6.
  7. 07LabIn vitro (cells)Activity measurement

    In human fetal pituitary cultures, GHRP‑6 and GHRP-2 at 100 nmol/L had similar effects in stimulating human GH release.

    In plain wordsIn cells from human fetal pituitary, GHRP‑6 and GHRP-2 raised growth hormone release by a similar amount.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH release at 100 nmol/L compared with GHRP-2
    Study

    humann: not reported in source

    primary human fetal pituitary cultures
    Comparator
    GHRP-2 100 nmol/L
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    100 nmol/LAs given in this study (human).

    Source sentences

    Summary
    GHRP-6 and GHRP-2 (100 nmol/L) had similar effects in stimulating human GH release.
    1 context sentence
    Summary · context
    Therefore, primary human fetal pituitary cultures (second and third trimesters) were treated with GHRP-6.
  8. 08LabIn vitro (cells)Activity measurement

    In human fetal pituitary cultures, GHRP‑2 and GHRP-6 at 100 nmol/L had similar effects in stimulating human GH release.

    In plain wordsIn cells from human fetal pituitary, GHRP‑2 and GHRP-6 raised growth hormone release by a similar amount.

    Peptide
    GHRP-2
    Outcome
    IncreaseGH release at 100 nmol/L compared with GHRP-6
    Study

    humann: not reported in source

    primary human fetal pituitary cultures
    Comparator
    GHRP-6 100 nmol/L
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    100 nmol/LAs given in this study (human).

    Source sentences

    Summary
    GHRP-6 and GHRP-2 (100 nmol/L) had similar effects in stimulating human GH release.
    1 context sentence
    Summary · context
    Therefore, primary human fetal pituitary cultures (second and third trimesters) were treated with GHRP-6.

Studies that did not test the peptide alone1

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 09LabNot a test of GHRP-6 aloneIn vitro (cells)Activity measurement

    In human fetal pituitary cultures, GHRP together with GHRH was additive, with up to 2.8-fold GH induction and no further synergy.

    In plain wordsIn cells from human fetal pituitary, GHRP plus GHRH together raised growth hormone in an additive way.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH induction with GHRP plus GHRH
    Study

    humann: not reported in source

    primary human fetal pituitary cultures
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    GH induction
    2.8 fold
    GHRP plus GHRH

    Source sentences

    Summary
    However, GHRP together with GHRH was additive (up to 2.8-fold GH induction) with no evidence of further positive synergy.
    1 context sentence
    Summary · context
    Therefore, primary human fetal pituitary cultures (second and third trimesters) were treated with GHRP-6.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 2

    13 Oct 2026, 16:31 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.