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Study · Animal study (in vivo) · dog · 1997

9 results

Effects of intermittent administration of low dose human PTH(1-34) on cancellous and cortical bone of lumbar vertebral bodies in adult beagles.

Zhang L, Takahashi HE, Inoue J, Tanizawa T, Endo N, Yamamoto N, Hori M

Bone1 Dec 1997Cited by 29 (Europe PMC)

PMID9430239 (opens in a new tab)DOI10.1016/s8756-3282(97)00198-1 (opens in a new tab)PepBankPUB-09430239
Publisher pagePubMedAsk about this study
Jump to 9 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In beagles, PTH increased mean cancellous osteoid surface versus age-related controls.

    In plain wordsIn dogs, PTH increased mean osteoid surface in spongy bone versus age-related controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseOsteoid surface
    Study

    Dogn: not reported in source

    Intact adult male beagles
    Comparator
    Age-related controls
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.375 microg/kg three times per week · injection · 24 weeksAs given in this study (Dog).

    Measurements

    Osteoid surface change
    74%
    PTH versus controls

    Source sentences

    Summary
    In intact adult beagles, on the group treated with 0.375 microg/kg per day three times per week (group 4): (1) had a higher mean value in cancellous bone formation parameters [osteoid surface (+74%), osteoid volume (twofold), mineral apposition rate (+21%), and bone formation rate (twofold)]
    2 context sentences
    Summary · context
    This study assessed the effect of low dose human parathyroid hormone [hPTH(1-34)] administration on cancellous and cortical bone of lumbar vertebrae in intact male beagles.
    Summary · context
    in group 3, the same dose of PTH was injected once per week for 24 weeks; and, in group 4, PTH was injected three times per week for 24 weeks.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In beagles, PTH increased mean cancellous osteoid volume versus age-related controls.

    In plain wordsIn dogs, PTH increased mean osteoid volume in spongy bone versus age-related controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseOsteoid volume
    Study

    Dogn: not reported in source

    Intact adult male beagles
    Comparator
    Age-related controls
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.375 microg/kg three times per week · injection · 24 weeksAs given in this study (Dog).

    Source sentences

    Summary
    In intact adult beagles, on the group treated with 0.375 microg/kg per day three times per week (group 4): (1) had a higher mean value in cancellous bone formation parameters [osteoid surface (+74%), osteoid volume (twofold), mineral apposition rate (+21%), and bone formation rate (twofold)]
    2 context sentences
    Summary · context
    This study assessed the effect of low dose human parathyroid hormone [hPTH(1-34)] administration on cancellous and cortical bone of lumbar vertebrae in intact male beagles.
    Summary · context
    in group 3, the same dose of PTH was injected once per week for 24 weeks; and, in group 4, PTH was injected three times per week for 24 weeks.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In beagles, PTH increased mean mineral apposition rate versus age-related controls.

    In plain wordsIn dogs, PTH increased mean mineral deposition rate versus age-related controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseMineral apposition rate
    Study

    Dogn: not reported in source

    Intact adult male beagles
    Comparator
    Age-related controls
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.375 microg/kg three times per week · injection · 24 weeksAs given in this study (Dog).

    Measurements

    Mineral apposition rate change
    21%
    PTH versus controls

    Source sentences

    Summary
    In intact adult beagles, on the group treated with 0.375 microg/kg per day three times per week (group 4): (1) had a higher mean value in cancellous bone formation parameters [osteoid surface (+74%), osteoid volume (twofold), mineral apposition rate (+21%), and bone formation rate (twofold)]
    2 context sentences
    Summary · context
    This study assessed the effect of low dose human parathyroid hormone [hPTH(1-34)] administration on cancellous and cortical bone of lumbar vertebrae in intact male beagles.
    Summary · context
    in group 3, the same dose of PTH was injected once per week for 24 weeks; and, in group 4, PTH was injected three times per week for 24 weeks.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In beagles, PTH increased mean cancellous bone formation rate versus age-related controls.

    In plain wordsIn dogs, PTH increased mean spongy bone formation rate versus age-related controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseBone formation rate
    Study

    Dogn: not reported in source

    Intact adult male beagles
    Comparator
    Age-related controls
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.375 microg/kg three times per week · injection · 24 weeksAs given in this study (Dog).

    Source sentences

    Summary
    In intact adult beagles, on the group treated with 0.375 microg/kg per day three times per week (group 4): (1) had a higher mean value in cancellous bone formation parameters [osteoid surface (+74%), osteoid volume (twofold), mineral apposition rate (+21%), and bone formation rate (twofold)]
    2 context sentences
    Summary · context
    This study assessed the effect of low dose human parathyroid hormone [hPTH(1-34)] administration on cancellous and cortical bone of lumbar vertebrae in intact male beagles.
    Summary · context
    in group 3, the same dose of PTH was injected once per week for 24 weeks; and, in group 4, PTH was injected three times per week for 24 weeks.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In beagles, PTH did not affect cortical thickness in either ventral or dorsal shells versus controls.

    In plain wordsIn dogs, PTH did not affect cortical thickness in either shell versus age-related controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeCortical thickness
    Study

    Dogn: not reported in source

    Intact adult male beagles
    Comparator
    Age-related controls
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.375 microg/kg three times per week · injection · 24 weeksAs given in this study (Dog).

    Source sentences

    Summary
    (2) exhibited no effect on cortical thickness and porosity in both the ventral and dorsal shell;
    2 context sentences
    Summary · context
    This study assessed the effect of low dose human parathyroid hormone [hPTH(1-34)] administration on cancellous and cortical bone of lumbar vertebrae in intact male beagles.
    Summary · context
    in group 3, the same dose of PTH was injected once per week for 24 weeks; and, in group 4, PTH was injected three times per week for 24 weeks.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In beagles, PTH did not affect cortical porosity in either ventral or dorsal shells versus controls.

    In plain wordsIn dogs, PTH did not affect cortical porosity in either shell versus age-related controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeCortical porosity
    Study

    Dogn: not reported in source

    Intact adult male beagles
    Comparator
    Age-related controls
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.375 microg/kg three times per week · injection · 24 weeksAs given in this study (Dog).

    Source sentences

    Summary
    (2) exhibited no effect on cortical thickness and porosity in both the ventral and dorsal shell;
    2 context sentences
    Summary · context
    This study assessed the effect of low dose human parathyroid hormone [hPTH(1-34)] administration on cancellous and cortical bone of lumbar vertebrae in intact male beagles.
    Summary · context
    in group 3, the same dose of PTH was injected once per week for 24 weeks; and, in group 4, PTH was injected three times per week for 24 weeks.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In beagles, PTH lowered mean node-to-termini values versus age-related controls.

    In plain wordsIn dogs, PTH lowered mean node-to-termini values versus age-related controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseNode to termini
    Study

    Dogn: not reported in source

    Intact adult male beagles
    Comparator
    Age-related controls
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.375 microg/kg three times per week · injection · 24 weeksAs given in this study (Dog).

    Measurements

    Node to termini
    0.11
    PTH
    Node to termini
    0.22
    controls

    Source sentences

    Summary
    (3) showed a lower mean value of node to termini (0.11 +/- 0.02 vs. 0.22 +/- 0.09) and a higher mean value of cortex to node (0.18 +/- 0.06 vs. 0.08 +/- 0.02), but not in trabeculae to trabeculae node, than age-related controls.
    2 context sentences
    Summary · context
    This study assessed the effect of low dose human parathyroid hormone [hPTH(1-34)] administration on cancellous and cortical bone of lumbar vertebrae in intact male beagles.
    Summary · context
    in group 3, the same dose of PTH was injected once per week for 24 weeks; and, in group 4, PTH was injected three times per week for 24 weeks.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In beagles, PTH increased mean cortex-to-node values versus age-related controls.

    In plain wordsIn dogs, PTH increased mean cortex-to-node values versus age-related controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCortex to node
    Study

    Dogn: not reported in source

    Intact adult male beagles
    Comparator
    Age-related controls
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.375 microg/kg three times per week · injection · 24 weeksAs given in this study (Dog).

    Measurements

    Cortex to node
    0.18
    PTH
    Cortex to node
    0.08
    controls

    Source sentences

    Summary
    (3) showed a lower mean value of node to termini (0.11 +/- 0.02 vs. 0.22 +/- 0.09) and a higher mean value of cortex to node (0.18 +/- 0.06 vs. 0.08 +/- 0.02), but not in trabeculae to trabeculae node, than age-related controls.
    2 context sentences
    Summary · context
    This study assessed the effect of low dose human parathyroid hormone [hPTH(1-34)] administration on cancellous and cortical bone of lumbar vertebrae in intact male beagles.
    Summary · context
    in group 3, the same dose of PTH was injected once per week for 24 weeks; and, in group 4, PTH was injected three times per week for 24 weeks.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In beagles, PTH did not alter trabeculae-to-trabeculae node values versus age-related controls.

    In plain wordsIn dogs, PTH did not alter trabeculae-to-trabeculae node values versus age-related controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeTrabeculae to trabeculae node
    Study

    Dogn: not reported in source

    Intact adult male beagles
    Comparator
    Age-related controls
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.375 microg/kg three times per week · injection · 24 weeksAs given in this study (Dog).

    Source sentences

    Summary
    (3) showed a lower mean value of node to termini (0.11 +/- 0.02 vs. 0.22 +/- 0.09) and a higher mean value of cortex to node (0.18 +/- 0.06 vs. 0.08 +/- 0.02), but not in trabeculae to trabeculae node, than age-related controls.
    2 context sentences
    Summary · context
    This study assessed the effect of low dose human parathyroid hormone [hPTH(1-34)] administration on cancellous and cortical bone of lumbar vertebrae in intact male beagles.
    Summary · context
    in group 3, the same dose of PTH was injected once per week for 24 weeks; and, in group 4, PTH was injected three times per week for 24 weeks.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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