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Study · Measured the body's own peptide · 1997

4 results

Presence of a bioactive and immunoreactive growth-hormone-releasing-factor-like substance in porcine placenta.

Farmer C, Gaudreau P

Biology of the neonate1 Jan 1997Cited by 3 (Europe PMC)

PMID9428996 (opens in a new tab)DOI10.1159/000244506 (opens in a new tab)PepBankPUB-09428996
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelEx vivo tissueOther

    In porcine placenta from sows at 110 days of gestation, an immunoreactive GRF content was detected in the placental extract.

    In plain wordsIn pig placenta tissue, a natural GRF-like substance (the body's own GRF) was detected.

    Peptide
    Sermorelin
    Outcome
    Not applicableImmunoreactive GRF content of porcine placental extract
    Study

    pign: not reported in source

    Porcine placental extract (110 days of gestation)
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Immunoreactive GRF content
    52 to 63 ng/mg dry weight
    placental extract, 110 days of gestation

    Source sentences

    Summary
    In addition, using a placental extract from 110 days of gestation, an immunoreactive GRF content of 52-63 ng/mg dry weight was detected.
    1 context sentence
    Summary · context
    Various concentrations of placental extracts from sows at 90 and 110 days of gestation were added to porcine anterior pituitary cells in culture.

    This result measures the body's own Sermorelin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Activity measurement

    In cultured porcine anterior pituitary cells, increasing concentrations of porcine placental extract significantly increased GH production.

    In plain wordsIn lab-grown pig pituitary cells, pig placenta extract increased growth hormone production, pointing to a natural GRF-like substance.

    Peptide
    Sermorelin
    Outcome
    IncreaseGH production in pituitary cells with placental extract
    Study

    pign: not reported in source

    Cultured porcine anterior pituitary cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Significant effects on GH production were obtained with increasing concentrations of placental extracts (p < 0.001).
    1 context sentence
    Summary · context
    Various concentrations of placental extracts from sows at 90 and 110 days of gestation were added to porcine anterior pituitary cells in culture.

    This result measures the body's own Sermorelin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelIn vitro (cells)Mechanism

    In cultured porcine anterior pituitary cells, the GH response to placental extract was significantly diminished by a GRF receptor antagonist.

    In plain wordsIn lab-grown pig pituitary cells, blocking the GRF receptor reduced the growth hormone response to placenta extract with the body's own GRF-like substance.

    Peptide
    Sermorelin
    Outcome
    DecreaseExtract-induced GH response with GRF receptor antagonist
    Study

    pign: not reported in source

    Cultured porcine anterior pituitary cells
    Comparator
    Extract without antagonist
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    This response was significantly diminished in the presence of the GRF receptor antagonist (p < 0.001).
    2 context sentences
    Summary · context
    Experiments were also performed in the presence of the GRF receptor antagonist N alpha-acetyl(D-Arg2-Ala15) rat GRF(1-29)NH2 (10(-7) M).
    Summary · context
    Various concentrations of placental extracts from sows at 90 and 110 days of gestation were added to porcine anterior pituitary cells in culture.

    This result measures the body's own Sermorelin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04LabEndogenous levelIn vitro (cells)Other

    In cultured porcine anterior pituitary cells, the gestational age of the placenta at collection did not significantly affect extract-induced GH secretion.

    In plain wordsIn lab-grown pig pituitary cells, the age of the pregnancy at placenta collection did not change the response to the body's own GRF-like substance.

    Peptide
    Sermorelin
    Outcome
    No significant changeEffect of gestational age on extract-induced GH secretion
    Study

    pign: not reported in source

    Cultured porcine anterior pituitary cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    The effect of gestational age at the time of collection of the placenta was nonsignificant (p > 0.1).
    1 context sentence
    Summary · context
    Various concentrations of placental extracts from sows at 90 and 110 days of gestation were added to porcine anterior pituitary cells in culture.

    This result measures the body's own Sermorelin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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