Skip to content

Study · Observational study · n = 25 · 1997

3 results

Germ cell apoptosis after treatment of cryptorchidism with human chorionic gonadotropin is associated with impaired reproductive function in the adult.

Dunkel L, Taskinen S, Hovatta O, Tilly JL, Wikström S

The Journal of clinical investigation1 Nov 1997Cited by 98 (Europe PMC)

PMID9410913 (opens in a new tab)PMCIDPMC508431 (opens in a new tab)DOI10.1172/jci119773 (opens in a new tab)PepBankPUB-09410913
Source linkPubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanObservational studySafety outcome

    In men with surgically treated cryptorchidism, prior hCG treatment was linked to more extensive apoptotic spermatogonia labeling than no hCG.

    In plain wordsIn men with cryptorchidism, prior hCG treatment was linked to more dying sperm precursor cells than no hCG.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    IncreaseApoptotic spermatogonia labeling
    Study

    n = 25

    Comparator
    Patients not treated with hCG
    Outcome group
    Adverse events · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Only a few scattered apoptotic spermatogonias were seen by end-labeling of biopsies from patients not treated with hCG, whereas more extensive labeling of spermatogonia was seen after hCG treatment.
    2 context sentences
    Summary · context
    25 adult men with a history of surgically treated cryptorchidism were studied, 15 of whom had received an unsuccessful human chorionic gonadotropin (hCG) therapy before orchidopexy.
    Summary · context
    Apoptotic DNA fragmentation was assayed in testis biopsies taken during orchidopexy by end-labeling, both in extracted DNA and histochemically in situ.
  2. 02HumanObservational studyEfficacy outcome

    In men with surgically treated cryptorchidism, semen analysis findings were similar between groups with and without prior hCG treatment.

    In plain wordsIn men with cryptorchidism, semen analysis was similar between groups with and without prior hCG treatment.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    No significant changeSemen analysis
    Study

    n = 25

    Comparator
    Patients not treated with hCG
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Findings in the semen analysis were similar between the groups.
    2 context sentences
    Summary · context
    25 adult men with a history of surgically treated cryptorchidism were studied, 15 of whom had received an unsuccessful human chorionic gonadotropin (hCG) therapy before orchidopexy.
    Summary · context
    Apoptotic DNA fragmentation was assayed in testis biopsies taken during orchidopexy by end-labeling, both in extracted DNA and histochemically in situ.
  3. 03HumanObservational studySafety outcome

    In men with cryptorchidism, prior hCG treatment was linked to 4.3-fold higher low molecular weight DNA than in non-hCG-treated scrotal testes.

    In plain wordsIn men with cryptorchidism, prior hCG treatment was linked to more fragmented DNA than in non-hCG-treated scrotal testes.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    IncreaseLow molecular weight DNA
    Study

    n: not reported in source

    Comparator
    Scrotal testis of non-hCG-treated patients
    Outcome group
    Adverse events · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    Low molecular weight DNA, hCG group versus non-hCG scrotal testis
    4.3 fold higher
    gel electrophoresis, P < 0.001
    P value for low molecular weight DNA comparison
    < 0.001 p value
    hCG-treated group versus scrotal testis of non-hCG-treated patients, gel electrophoresis

    Source sentences

    Summary
    As estimated by gel electrophoresis, the amount of low molecular weight DNA was 4.3-fold higher in the hCG-treated group when compared with the level in scrotal testis of non-hCG-treated patients (P < 0.001).
    2 context sentences
    Summary · context
    25 adult men with a history of surgically treated cryptorchidism were studied, 15 of whom had received an unsuccessful human chorionic gonadotropin (hCG) therapy before orchidopexy.
    Summary · context
    Apoptotic DNA fragmentation was assayed in testis biopsies taken during orchidopexy by end-labeling, both in extracted DNA and histochemically in situ.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.