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Study · In vitro (cells) · 1997

1 result

Human renal fibroblasts modulate proximal tubule cell growth and transport via the IGF-I axis.

Johnson DW, Saunders HJ, Brew BK, Ganesan A, Baxter RC, Poronnik P, Cook DI, Györy AZ, Field MJ, Pollock CA

Kidney international1 Dec 1997Cited by 40 (Europe PMC)

PMID9407494 (opens in a new tab)DOI10.1038/ki.1997.479 (opens in a new tab)PepBankPUB-09407494
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In human proximal tubule cells, des(1‑3)IGF-I stimulated growth less potently than IGF-I.

    In plain wordsIn cells, des(1‑3)IGF-I stimulated kidney tubule cell growth less strongly than IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseProximal tubule cell growth
    Study

    humann: not reported in source

    Primary human proximal tubule cells
    Comparator
    IGF-I
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Des(1-3)IGF-I, an analog that binds to the IGF-I receptor but not to IGFBPs, provided a less potent stimulus for PTC growth compared with IGF-I, indicating that cell-associated IGFBP-3 facilitates the action of IGF-I on PTC.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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