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Study · Animal study (in vivo) · 1997

2 results

Studies of the mechanism of the anticonvulsant effect of delta-sleep-inducing peptide in conditions of increased oxygen tension.

Mendzheritskii AM, Lysenko AV, Uskova NI, Sametskii EA

Neuroscience and behavioral physiology1 Nov 1997Cited by 7 (Europe PMC)

PMID9406227 (opens in a new tab)DOI10.1007/bf02461934 (opens in a new tab)PepBankPUB-09406227
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In animals exposed to hyperbaric oxygen at 0.7 MPa, intraperitoneal DSIP delayed the onset of generalized convulsive activity by a factor of 2-2.5.

    In plain wordsIn animals exposed to high oxygen pressure, DSIP delayed the start of convulsions by 2 to 2.5 times.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseOnset of generalized convulsive activity under hyperbaric oxygen
    Study

    n: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    12 micrograms/100 g · intraperitonealAs given in this study.

    Measurements

    Delay of convulsion onset
    2 to 2.5 fold
    DSIP 12 micrograms/100 g

    Source sentences

    Summary
    Intraperitoneal administration of this dose of DSIP delayed the onset of generalized convulsive activity by a factor of 2-2.5 in animals exposed to an oxygen tension of 0.7 MPa
    1 context sentence
    Summary · context
    Studies of the protective actions of three doses of delta-sleep-inducing peptide (DSIP) given at different times before barochamber compression of animals to an oxygen tension of 0.7 MPa showed that the optimum DSIP dose is 12 micrograms/100 g.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In animals exposed to hyperbaric oxygen, intraperitoneal DSIP promoted normalization of the sleep-walking cycle within 24 h.

    In plain wordsIn animals exposed to high oxygen pressure, DSIP helped the sleep and waking cycle return to normal within 24 hours.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseNormalization of sleep-walking cycle within 24 h after hyperbaric oxygen
    Study

    n: not reported in source

    Outcome group
    Sleep · Sleep
    Studied dose
    12 micrograms/100 g · intraperitonealAs given in this study.

    Source sentences

    Summary
    promoted normalization of the sleep-walking cycle within 24 h after exposure to hyperbaric oxygen (HBO)
    1 context sentence
    Summary · context
    Studies of the protective actions of three doses of delta-sleep-inducing peptide (DSIP) given at different times before barochamber compression of animals to an oxygen tension of 0.7 MPa showed that the optimum DSIP dose is 12 micrograms/100 g.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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