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Study · Ex vivo tissue · rat · 1997

1 result

Insulin-like growth factors-I and -II differentially regulate endogenous acetylcholine release from the rat hippocampal formation.

Kar S, Seto D, Doré S, Hanisch U, Quirion R

Proceedings of the National Academy of Sciences of the United States of America1 Dec 1997Cited by 69 (Europe PMC)

PMID9391151 (opens in a new tab)PMCIDPMC28431 (opens in a new tab)DOI10.1073/pnas.94.25.14054 (opens in a new tab)PepBankPUB-09391151
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In rat hippocampal slices, des(1‑3) IGF-I inhibited potassium-evoked acetylcholine release.

    In plain wordsIn lab tests with rat brain slices, des(1‑3) IGF-I reduced potassium-triggered acetylcholine release.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreasePotassium-evoked acetylcholine release
    Study

    ratn: not reported in source

    Adult rat hippocampal slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10(-10)-10(-8) MAs given in this study (rat).

    Source sentences

    Summary
    IGF-I (10(-14)-10(-8) M) and des(1-3) IGF-I (10(-10)-10(-8) M) were found to inhibit whereas IGF-II (10(-14)-10(-8) M) potentiated K+-evoked ACh release from hippocampal slices.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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