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Study · Non-randomized trial · n = 47 · 1997

4 results

Effect of acadesine on myocardial ischaemia in patients with coronary artery disease.

de Jonge R, Macleod DC, Suryapranata H, van Es GA, Friedman J, Serruys PW, de Jong JW

European journal of pharmacology1 Oct 1997Cited by 9 (Europe PMC)

PMID9389379 (opens in a new tab)DOI10.1016/s0014-2999(97)01239-9 (opens in a new tab)PepBankPUB-09389379
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In patients undergoing coronary angiography, higher acadesine doses produced minor beneficial effects on ejection fraction.

    In plain wordsIn patients undergoing coronary angiography, higher acadesine doses slightly improved the heart's pumping fraction.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseEjection fraction
    Study

    n = 47

    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Higher doses, not specified · intravenousAs given in this study (human).

    Source sentences

    Summary
    At higher doses, minor beneficial effects on ejection fraction and myocardial lactate metabolism were observed.
    2 context sentences
    Summary · context
    This study examined its influence on pacing-induced ischaemia in 47 patients undergoing coronary angiography.
    Summary · context
    After 15 min of recovery from control pacing, an infusion of acadesine (5, 10, 20, 50 mg/kg i.v.) was commenced and after a further 15 min the protocol was repeated with the infusion continued.
  2. 02HumanNon-randomized trialEfficacy outcome

    In patients undergoing coronary angiography, higher acadesine doses produced minor beneficial effects on myocardial lactate metabolism.

    In plain wordsIn patients undergoing coronary angiography, higher acadesine doses slightly improved lactate metabolism in heart muscle.

    Peptide
    AICAR (acadesine)
    Outcome
    Direction not reportedMyocardial lactate metabolism
    Study

    n = 47

    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Higher doses, not specified · intravenousAs given in this study (human).

    Source sentences

    Summary
    At higher doses, minor beneficial effects on ejection fraction and myocardial lactate metabolism were observed.
    2 context sentences
    Summary · context
    This study examined its influence on pacing-induced ischaemia in 47 patients undergoing coronary angiography.
    Summary · context
    After 15 min of recovery from control pacing, an infusion of acadesine (5, 10, 20, 50 mg/kg i.v.) was commenced and after a further 15 min the protocol was repeated with the infusion continued.
  3. 03HumanNon-randomized trialEfficacy outcome

    In patients undergoing coronary angiography, acadesine did not affect haemodynamics.

    In plain wordsIn patients undergoing coronary angiography, acadesine did not change blood circulation measures.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeHaemodynamics
    Study

    n = 47

    Outcome group
    Heart function · Cardiovascular
    Studied dose
    5, 10, 20, 50 mg/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    Haemodynamics were unaffected.
    2 context sentences
    Summary · context
    This study examined its influence on pacing-induced ischaemia in 47 patients undergoing coronary angiography.
    Summary · context
    After 15 min of recovery from control pacing, an infusion of acadesine (5, 10, 20, 50 mg/kg i.v.) was commenced and after a further 15 min the protocol was repeated with the infusion continued.
  4. 04HumanNon-randomized trialMechanism

    In patients undergoing coronary angiography, acadesine increased systemic lactate by up to 60% versus placebo.

    In plain wordsIn patients undergoing coronary angiography, acadesine increased blood lactate compared with placebo.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseSystemic lactate
    Study

    n = 47

    Comparator
    Placebo
    Outcome group
    Metabolic pathways and metabolomics · Metabolic and weight
    Studied dose
    5, 10, 20, 50 mg/kg · intravenousAs given in this study (human).

    Measurements

    Systemic lactate rise
    ≤ 60%
    acadesine versus placebo
    P value
    < 0.001 NA
    versus placebo

    Source sentences

    Summary
    Systemic lactate rose in relation to acadesine, up to 60% (P < 0.001 versus placebo).
    2 context sentences
    Summary · context
    This study examined its influence on pacing-induced ischaemia in 47 patients undergoing coronary angiography.
    Summary · context
    After 15 min of recovery from control pacing, an infusion of acadesine (5, 10, 20, 50 mg/kg i.v.) was commenced and after a further 15 min the protocol was repeated with the infusion continued.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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