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Study · Randomized controlled trial · n = 5 · 1997

10 results

Short-term modulation of the androgen milieu alters pulsatile, but not exercise- or growth hormone (GH)-releasing hormone-stimulated GH secretion in healthy men: impact of gonadal steroid and GH secretory changes on metabolic outcomes.

Fryburg DA, Weltman A, Jahn LA, Weltman JY, Samojlik E, Hintz RL, Veldhuis JD

The Journal of clinical endocrinology and metabolism1 Nov 1997Cited by 36 (Europe PMC)

PMID9360530 (opens in a new tab)DOI10.1210/jcem.82.11.4379 (opens in a new tab)PepBankPUB-09360530
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. 10 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy young men, leuprolide-induced hypogonadism had serum testosterone of 33 ng/dL versus 796 ng/dL in the saline-induced eugonadal state.

    In plain wordsIn healthy men, testosterone was lower during leuprolide-induced hypogonadism than during the saline-induced eugonadal state.

    Peptide
    Leuprolide
    Outcome
    DecreaseSerum testosterone
    Study

    n = 5

    Comparator
    Saline-induced eugonadal state
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Serum testosterone
    33 ng/dL
    hypogonadal state induced by leuprolide
    Serum testosterone
    796 ng/dL
    eugonadal state (saline)

    Source sentences

    Summary
    The hypogonadal state (serum testosterone, 33 ng/dL) increased urinary nitrogen loss (by 34%; P < 0.005) and decreased basal metabolic rate (by 12%; P < 0.02) compared with the eugonadal state (testosterone, 796 ng/dL).
    3 context sentences
    Summary · context
    In the first paradigm, 5 healthy young men were each studied in a double blind, randomized manner during 3 different gonadal hormone manipulations, in which serum testosterone was varied from hypogonadal (induced by leuprolide) to eugonadal (saline injections) to high levels (testosterone enanthate,…
    Summary · context
    There was a washout period of 8 weeks between treatments.
    Summary · context
    Two to 3 weeks after the desired changes in serum testosterone, each subject was admitted to the General Clinical Research Center for study.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy young men, leuprolide-induced hypogonadism increased urinary nitrogen loss by 34% versus the eugonadal state (P < 0.005).

    In plain wordsIn healthy men, leuprolide-induced hypogonadism increased urinary nitrogen loss versus the saline-induced eugonadal state.

    Peptide
    Leuprolide
    Outcome
    IncreaseUrinary nitrogen loss
    Study

    n = 5

    Comparator
    Saline-induced eugonadal state
    Outcome group
    Protein and amino acid metabolism · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    Urinary nitrogen loss increase
    34%
    hypogonadal versus eugonadal state

    Source sentences

    Summary
    The hypogonadal state (serum testosterone, 33 ng/dL) increased urinary nitrogen loss (by 34%; P < 0.005) and decreased basal metabolic rate (by 12%; P < 0.02) compared with the eugonadal state (testosterone, 796 ng/dL).
    3 context sentences
    Summary · context
    In the first paradigm, 5 healthy young men were each studied in a double blind, randomized manner during 3 different gonadal hormone manipulations, in which serum testosterone was varied from hypogonadal (induced by leuprolide) to eugonadal (saline injections) to high levels (testosterone enanthate,…
    Summary · context
    There was a washout period of 8 weeks between treatments.
    Summary · context
    Two to 3 weeks after the desired changes in serum testosterone, each subject was admitted to the General Clinical Research Center for study.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In healthy young men, leuprolide-induced hypogonadism decreased basal metabolic rate by 12% versus the eugonadal state (P < 0.02).

    In plain wordsIn healthy men, leuprolide-induced hypogonadism lowered basal metabolic rate versus the saline-induced eugonadal state.

    Peptide
    Leuprolide
    Outcome
    DecreaseBasal metabolic rate
    Study

    n = 5

    Comparator
    Saline-induced eugonadal state
    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    Basal metabolic rate decrease
    12%
    hypogonadal versus eugonadal state

    Source sentences

    Summary
    The hypogonadal state (serum testosterone, 33 ng/dL) increased urinary nitrogen loss (by 34%; P < 0.005) and decreased basal metabolic rate (by 12%; P < 0.02) compared with the eugonadal state (testosterone, 796 ng/dL).
    3 context sentences
    Summary · context
    In the first paradigm, 5 healthy young men were each studied in a double blind, randomized manner during 3 different gonadal hormone manipulations, in which serum testosterone was varied from hypogonadal (induced by leuprolide) to eugonadal (saline injections) to high levels (testosterone enanthate,…
    Summary · context
    There was a washout period of 8 weeks between treatments.
    Summary · context
    Two to 3 weeks after the desired changes in serum testosterone, each subject was admitted to the General Clinical Research Center for study.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In healthy young men, end-exercise oxygen consumption was lower in the leuprolide-induced hypogonadal state than the eugonadal state (P < 0.05).

    In plain wordsIn healthy men, end-exercise oxygen consumption was lower during leuprolide-induced hypogonadism than during the saline-induced eugonadal state.

    Peptide
    Leuprolide
    Outcome
    DecreaseEnd-exercise oxygen consumption
    Study

    n = 5

    Comparator
    Saline-induced eugonadal state
    Outcome group
    Exercise and physical function · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    Oxygen consumption rise
    11%
    from hypogonadal to eugonadal state

    Source sentences

    Summary
    Analogously, end-exercise oxygen consumption rose by 11% between the hypogonadal and eugonadal states (P < 0.05).
    3 context sentences
    Summary · context
    In the first paradigm, 5 healthy young men were each studied in a double blind, randomized manner during 3 different gonadal hormone manipulations, in which serum testosterone was varied from hypogonadal (induced by leuprolide) to eugonadal (saline injections) to high levels (testosterone enanthate,…
    Summary · context
    There was a washout period of 8 weeks between treatments.
    Summary · context
    Two to 3 weeks after the desired changes in serum testosterone, each subject was admitted to the General Clinical Research Center for study.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In healthy young men, pulsatile GH secretion did not differ significantly between leuprolide-induced hypogonadal and eugonadal states.

    In plain wordsIn healthy men, pulsatile GH secretion did not differ significantly between leuprolide-induced hypogonadism and the saline-induced eugonadal state.

    Peptide
    Leuprolide
    Outcome
    No significant changePulsatile GH secretion
    Study

    n = 5

    Comparator
    Saline-induced eugonadal state
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Between the hypogonadal and eugonadal states, no significant changes in pulsatile (nonstimulated), exercise-stimulated, or GRF-stimulated GH secretion or serum insulin-like growth factor I concentrations were observed.
    3 context sentences
    Summary · context
    In the first paradigm, 5 healthy young men were each studied in a double blind, randomized manner during 3 different gonadal hormone manipulations, in which serum testosterone was varied from hypogonadal (induced by leuprolide) to eugonadal (saline injections) to high levels (testosterone enanthate,…
    Summary · context
    There was a washout period of 8 weeks between treatments.
    Summary · context
    Two to 3 weeks after the desired changes in serum testosterone, each subject was admitted to the General Clinical Research Center for study.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In healthy young men, exercise-stimulated GH secretion did not differ significantly between leuprolide-induced hypogonadal and eugonadal states.

    In plain wordsIn healthy men, exercise-stimulated GH secretion did not differ significantly between leuprolide-induced hypogonadism and the saline-induced eugonadal state.

    Peptide
    Leuprolide
    Outcome
    No significant changeExercise-stimulated GH secretion
    Study

    n = 5

    Comparator
    Saline-induced eugonadal state
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Between the hypogonadal and eugonadal states, no significant changes in pulsatile (nonstimulated), exercise-stimulated, or GRF-stimulated GH secretion or serum insulin-like growth factor I concentrations were observed.
    3 context sentences
    Summary · context
    In the first paradigm, 5 healthy young men were each studied in a double blind, randomized manner during 3 different gonadal hormone manipulations, in which serum testosterone was varied from hypogonadal (induced by leuprolide) to eugonadal (saline injections) to high levels (testosterone enanthate,…
    Summary · context
    There was a washout period of 8 weeks between treatments.
    Summary · context
    Two to 3 weeks after the desired changes in serum testosterone, each subject was admitted to the General Clinical Research Center for study.
  7. 07HumanRandomized controlled trialEfficacy outcome

    In healthy young men, GRF-stimulated GH secretion did not differ significantly between leuprolide-induced hypogonadal and eugonadal states.

    In plain wordsIn healthy men, GRF-stimulated GH secretion did not differ significantly between leuprolide-induced hypogonadism and the saline-induced eugonadal state.

    Peptide
    Leuprolide
    Outcome
    No significant changeGRF-stimulated GH secretion
    Study

    n = 5

    Comparator
    Saline-induced eugonadal state
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Between the hypogonadal and eugonadal states, no significant changes in pulsatile (nonstimulated), exercise-stimulated, or GRF-stimulated GH secretion or serum insulin-like growth factor I concentrations were observed.
    3 context sentences
    Summary · context
    In the first paradigm, 5 healthy young men were each studied in a double blind, randomized manner during 3 different gonadal hormone manipulations, in which serum testosterone was varied from hypogonadal (induced by leuprolide) to eugonadal (saline injections) to high levels (testosterone enanthate,…
    Summary · context
    There was a washout period of 8 weeks between treatments.
    Summary · context
    Two to 3 weeks after the desired changes in serum testosterone, each subject was admitted to the General Clinical Research Center for study.
  8. 08HumanRandomized controlled trialEfficacy outcome

    In healthy young men, serum insulin-like growth factor I did not differ significantly between leuprolide-induced hypogonadal and eugonadal states.

    In plain wordsIn healthy men, insulin-like growth factor I did not differ significantly between leuprolide-induced hypogonadism and the saline-induced eugonadal state.

    Peptide
    Leuprolide
    Outcome
    No significant changeSerum insulin-like growth factor I
    Study

    n = 5

    Comparator
    Saline-induced eugonadal state
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Between the hypogonadal and eugonadal states, no significant changes in pulsatile (nonstimulated), exercise-stimulated, or GRF-stimulated GH secretion or serum insulin-like growth factor I concentrations were observed.
    3 context sentences
    Summary · context
    In the first paradigm, 5 healthy young men were each studied in a double blind, randomized manner during 3 different gonadal hormone manipulations, in which serum testosterone was varied from hypogonadal (induced by leuprolide) to eugonadal (saline injections) to high levels (testosterone enanthate,…
    Summary · context
    There was a washout period of 8 weeks between treatments.
    Summary · context
    Two to 3 weeks after the desired changes in serum testosterone, each subject was admitted to the General Clinical Research Center for study.
  9. 09HumanRandomized controlled trialEfficacy outcome

    In healthy young men, pulsatile GH secretion was lower with leuprolide than high-dose testosterone, which increased secretion by 62% over leuprolide.

    In plain wordsIn healthy men, pulsatile GH secretion was lower with leuprolide than with high-dose testosterone.

    Peptide
    Leuprolide
    Outcome
    DecreasePulsatile GH secretion versus testosterone
    Study

    n = 5

    Comparator
    High-dose testosterone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Pulsatile GH secretion increase with testosterone over leuprolide
    62%
    high-dose testosterone versus leuprolide-induced hypogonadism

    Source sentences

    Summary
    Raising testosterone to supraphysiological levels increased pulsatile GH secretion by 62% over that with leuprolide and by 22% over that with saline (P < 0.05).
    3 context sentences
    Summary · context
    In the first paradigm, 5 healthy young men were each studied in a double blind, randomized manner during 3 different gonadal hormone manipulations, in which serum testosterone was varied from hypogonadal (induced by leuprolide) to eugonadal (saline injections) to high levels (testosterone enanthate,…
    Summary · context
    There was a washout period of 8 weeks between treatments.
    Summary · context
    Two to 3 weeks after the desired changes in serum testosterone, each subject was admitted to the General Clinical Research Center for study.
  10. 10HumanRandomized controlled trialEfficacy outcome

    In healthy young men, high-dose testosterone produced insulin-like growth factor I concentrations 34% above those during leuprolide-induced hypogonadism (P < 0.01).

    In plain wordsIn healthy men, insulin-like growth factor I was lower during leuprolide-induced hypogonadism than with high-dose testosterone.

    Peptide
    Leuprolide
    Outcome
    DecreaseInsulin-like growth factor I versus testosterone
    Study

    n = 5

    Comparator
    High-dose testosterone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Serum IGF-I increase with testosterone over hypogonadal state
    34%
    high-dose testosterone versus leuprolide-induced hypogonadism

    Source sentences

    Summary
    High dose testosterone treatment also increased serum insulin-like growth factor I concentrations by 21% and 34% over those during the eugonadal and hypogonadal states, respectively (P < 0.01).
    3 context sentences
    Summary · context
    In the first paradigm, 5 healthy young men were each studied in a double blind, randomized manner during 3 different gonadal hormone manipulations, in which serum testosterone was varied from hypogonadal (induced by leuprolide) to eugonadal (saline injections) to high levels (testosterone enanthate,…
    Summary · context
    There was a washout period of 8 weeks between treatments.
    Summary · context
    Two to 3 weeks after the desired changes in serum testosterone, each subject was admitted to the General Clinical Research Center for study.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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