In cells expressing human melanocortin receptors, the cyclic lactam MSH (4-10) analogues (MTII and SHU9119) had higher overall receptor affinity than the cyclic disulphide analogues.
In plain wordsIn cells, cyclic lactam analogues, including MTII, bound melanocortin receptors more strongly overall than cyclic disulphide analogues.
- Peptide
- Melanotan II
- Outcome
- IncreaseMelanocortin receptor binding affinity of cyclic lactam versus disulphide analogues
- Study
humann: not reported in source
Cells transiently expressing human MC1, MC3, MC4 and MC5 receptors- Comparator
- Cyclic disulphide MSH (4-10) analogues
- Outcome group
- Receptor activity and mechanism · Pharmacology
Source sentences
However, the cyclic lactams displayed an over all higher affinity for the MC receptors, than any of the cyclic disulphide MSH (4-10) analogues.
1 context sentence(design, population, supporting numbers)
The binding of the 2 cyclic lactam MSH (4-10) analogues (MTII, SHU9119), and 5 cyclic [Cys4, Cys10] alpha-MSH analogues were tested on cells transiently expressing the human MC1, MC3, MC4 and MC5 receptors.
In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.