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Study · In vitro (cells) · rat · 1997

4 results

Insulin-like growth factors stimulate expression of hepatocyte growth factor but not transforming growth factor beta1 in cultured hepatic stellate cells.

Skrtic S, Wallenius V, Ekberg S, Brenzel A, Gressner AM, Jansson JO

Endocrinology1 Nov 1997Cited by 42 (Europe PMC)

PMID9348194 (opens in a new tab)DOI10.1210/endo.138.11.5540 (opens in a new tab)PepBankPUB-09348194
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In rat hepatic stellate cell cultures, des(1‑3)IGF-I enhanced hepatocyte growth factor levels.

    In plain wordsIn cells from rats, des(1‑3)IGF-I increased hepatocyte growth factor levels.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseHepatocyte growth factor concentration
    Study

    ratn: not reported in source

    Primary rat hepatic stellate cell cultures
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The levels of HGF as well as DNA synthesis measured as thymidine incorporation were also enhanced by IGF-II and des(1-3)IGF-I, which has reduced binding to IGF binding proteins.
    1 context sentence
    Summary · context
    In this study we found that addition of IGF-1 (20-500 ng/ml) for 48 h to 2- to 7-day-old primary cultures of rat HSC resulted in a time- and dose-dependent increase by 50-190% of the concentrations of immunoreactive HGF in the medium.
  2. 02LabIn vitro (cells)Activity measurement

    In rat hepatic stellate cell cultures, des(1‑3)IGF-I enhanced DNA synthesis measured by thymidine incorporation.

    In plain wordsIn cells from rats, des(1‑3)IGF-I increased DNA production.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseDNA synthesis
    Study

    ratn: not reported in source

    Primary rat hepatic stellate cell cultures
    Outcome group
    Receptor activity and mechanism · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The levels of HGF as well as DNA synthesis measured as thymidine incorporation were also enhanced by IGF-II and des(1-3)IGF-I, which has reduced binding to IGF binding proteins.
    1 context sentence
    Summary · context
    In this study we found that addition of IGF-1 (20-500 ng/ml) for 48 h to 2- to 7-day-old primary cultures of rat HSC resulted in a time- and dose-dependent increase by 50-190% of the concentrations of immunoreactive HGF in the medium.

Studies that did not test the peptide alone2

In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 DES (des(1-3)IGF-I).

  1. 03LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Activity measurement

    In rat hepatic stellate cell cultures, IGFs including des(1‑3)IGF-I had no consistent effect on immunoreactive TGFbeta1 levels.

    In plain wordsIn cells from rats, IGFs including des(1‑3)IGF-I did not consistently change TGFbeta1 levels.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeImmunoreactive TGFbeta1 levels
    Study

    ratn: not reported in source

    Primary rat hepatic stellate cell cultures
    Outcome group
    Liver fat and liver function · Liver

    Source sentences

    Summary
    There was no consistent effect of the IGFs on the levels of immunoreactive TGFbeta1 or on the total DNA content of the cultures.
    2 context sentences
    Summary · context
    The levels of HGF as well as DNA synthesis measured as thymidine incorporation were also enhanced by IGF-II and des(1-3)IGF-I, which has reduced binding to IGF binding proteins.
    Summary · context
    In this study we found that addition of IGF-1 (20-500 ng/ml) for 48 h to 2- to 7-day-old primary cultures of rat HSC resulted in a time- and dose-dependent increase by 50-190% of the concentrations of immunoreactive HGF in the medium.

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

  2. 04LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Activity measurement

    In rat hepatic stellate cell cultures, IGFs including des(1‑3)IGF-I had no consistent effect on total DNA content.

    In plain wordsIn cells from rats, IGFs including des(1‑3)IGF-I did not consistently change total DNA content.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeTotal DNA content
    Study

    ratn: not reported in source

    Primary rat hepatic stellate cell cultures
    Outcome group
    Receptor activity and mechanism · Liver

    Source sentences

    Summary
    There was no consistent effect of the IGFs on the levels of immunoreactive TGFbeta1 or on the total DNA content of the cultures.
    2 context sentences
    Summary · context
    The levels of HGF as well as DNA synthesis measured as thymidine incorporation were also enhanced by IGF-II and des(1-3)IGF-I, which has reduced binding to IGF binding proteins.
    Summary · context
    In this study we found that addition of IGF-1 (20-500 ng/ml) for 48 h to 2- to 7-day-old primary cultures of rat HSC resulted in a time- and dose-dependent increase by 50-190% of the concentrations of immunoreactive HGF in the medium.

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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