Immunohistochemical comparison of localization of pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) in the enteric nerve plexus of the guinea pig jejunum.

Suzuki M, Nokihara K, Ando E, Naruse S

Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity1 Jan 1996Cited by 4 (Europe PMC)

PMID9346832PepBankPUB-09346832

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
In guinea pig jejunum, nerve elements immunoreactive for PACAP and VIP were present in ganglia of both the myenteric and submucous plexi.
In plain wordsIn guinea pigs, nerve tissue stained for PACAP and the body's own VIP was found in both gut nerve networks.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableVIP-immunoreactive nerve elements in enteric ganglia
Study
guinea pign: not reported in source
Jejunal enteric nerve plexus immunohistochemistry
Outcome group
Endogenous peptide levels · Gastrointestinal
Source sentences
Summary
Immunoreactive nerve elements were demonstrated in the ganglia of both myenteric and submucous plexi in the guinea pig jejunum.
1 context sentence(design, population, supporting numbers)
Summary · context
The localization and co-localization of pituitary adenylate cyclase activating polypeptides (PACAPs) and vasoactive intestinal polypeptide (VIP) in the enteric nerve plexus of the guinea pig jejunum were immunohistochemically compared by the peroxidase anti-peroxidase (PAP) method using region-speci…
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0934683201
02AnimalEndogenous levelAnimal study (in vivo)Other
In guinea pig jejunum, numerous PACAP- and VIP-immunoreactive nerve cell bodies were in myenteric ganglia, but cell bodies in submucous ganglia were only slightly immunopositive.
In plain wordsIn guinea pigs, many nerve cells stained for the body's own VIP were in one gut nerve network, but only a few in the other.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableImmunoreactive nerve cell bodies in myenteric and submucous ganglia
Study
guinea pign: not reported in source
Jejunal enteric nerve plexus immunohistochemistry
Outcome group
Endogenous peptide levels · Gastrointestinal
Source sentences
Summary
Numerous immunoreactive nerve cell bodies were localized in the myenteric ganglia, while nerve cell bodies in the submucous ganglia were only slightly immunopositive.
1 context sentence(design, population, supporting numbers)
Summary · context
The localization and co-localization of pituitary adenylate cyclase activating polypeptides (PACAPs) and vasoactive intestinal polypeptide (VIP) in the enteric nerve plexus of the guinea pig jejunum were immunohistochemically compared by the peroxidase anti-peroxidase (PAP) method using region-speci…
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0934683202
03AnimalEndogenous levelAnimal study (in vivo)Other
In guinea pig jejunum, PACAP- and VIP-immunoreactive nerve terminal varicosities occurred in both myenteric and submucous ganglia.
In plain wordsIn guinea pigs, nerve endings stained for the body's own VIP were found in both gut nerve networks.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableImmunoreactive nerve terminal varicosities
Study
guinea pign: not reported in source
Jejunal enteric nerve plexus immunohistochemistry
Outcome group
Endogenous peptide levels · Gastrointestinal
Source sentences
Summary
Immunoreactive nerve terminal varicosities occurred in both myenteric and submucous ganglia.
1 context sentence(design, population, supporting numbers)
Summary · context
The localization and co-localization of pituitary adenylate cyclase activating polypeptides (PACAPs) and vasoactive intestinal polypeptide (VIP) in the enteric nerve plexus of the guinea pig jejunum were immunohistochemically compared by the peroxidase anti-peroxidase (PAP) method using region-speci…
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0934683203
04AnimalEndogenous levelAnimal study (in vivo)Other
In guinea pig jejunum, PACAP-immunoreactive nerve cell bodies were also immunopositive for VIP.
In plain wordsIn guinea pigs, gut nerve cells that contain PACAP also contain the body's own VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableCo-localization of PACAP and VIP in nerve cell bodies
Study
guinea pign: not reported in source
Jejunal enteric nerve plexus immunohistochemistry
Outcome group
Endogenous peptide levels · Gastrointestinal
Source sentences
Summary
Additionally, PACAPs-immunoreactive nerve cell bodies were also immunopositive with VIP.
1 context sentence(design, population, supporting numbers)
Summary · context
The localization and co-localization of pituitary adenylate cyclase activating polypeptides (PACAPs) and vasoactive intestinal polypeptide (VIP) in the enteric nerve plexus of the guinea pig jejunum were immunohistochemically compared by the peroxidase anti-peroxidase (PAP) method using region-speci…
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0934683204

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Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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