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Study · Animal study (in vivo) · rat · 1997

8 results

Oxytocin decreases blood pressure in male but not in female spontaneously hypertensive rats.

Petersson M, Lundeberg T, Uvnäs-Moberg K

Journal of the autonomic nervous system1 Sept 1997Cited by 37 (Europe PMC)

PMID9334988 (opens in a new tab)DOI10.1016/s0165-1838(97)00040-4 (opens in a new tab)PepBankPUB-09334988
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male spontaneously hypertensive rats, repeated oxytocin injections lowered systolic blood pressure versus saline from the day after the first injection.

    In plain wordsIn male hypertensive rats, oxytocin injections lowered systolic blood pressure more than saline.

    Peptide
    Oxytocin
    Outcome
    DecreaseSystolic blood pressure in male SHR
    Study

    ratn: not reported in source

    spontaneously hypertensive rats (SHR)
    Comparator
    Saline
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    1 mg/kg · subcutaneous · 5 daysAs given in this study (rat).

    Source sentences

    Summary
    In male rats, a significant decrease in blood pressure (systolic; p < 0.01, diastolic; p < 0.05), but no effect on heart rate, was seen the day after the first injection of oxytocin, when compared to saline-treated controls.
    1 context sentence
    Summary · context
    For this purpose subcutaneous (s.c.) injections of oxytocin 1 mg/kg or saline were given for 5 days to male and female SHR.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male spontaneously hypertensive rats, repeated oxytocin injections lowered diastolic blood pressure versus saline from the day after the first injection.

    In plain wordsIn male hypertensive rats, oxytocin injections lowered diastolic blood pressure more than saline.

    Peptide
    Oxytocin
    Outcome
    DecreaseDiastolic blood pressure in male SHR
    Study

    ratn: not reported in source

    spontaneously hypertensive rats (SHR)
    Comparator
    Saline
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    1 mg/kg · subcutaneous · 5 daysAs given in this study (rat).

    Source sentences

    Summary
    In male rats, a significant decrease in blood pressure (systolic; p < 0.01, diastolic; p < 0.05), but no effect on heart rate, was seen the day after the first injection of oxytocin, when compared to saline-treated controls.
    1 context sentence
    Summary · context
    For this purpose subcutaneous (s.c.) injections of oxytocin 1 mg/kg or saline were given for 5 days to male and female SHR.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male spontaneously hypertensive rats, the systolic blood pressure difference versus controls reached a maximum of 21 mmHg after the last oxytocin injection.

    In plain wordsIn male hypertensive rats, systolic blood pressure was lower than in controls by a maximum of 21 mmHg after the last oxytocin injection.

    Peptide
    Oxytocin
    Outcome
    DecreaseMaximal systolic blood pressure difference in male SHR
    Study

    ratn: not reported in source

    spontaneously hypertensive rats (SHR)
    Comparator
    Saline
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    1 mg/kg · subcutaneous · 5 daysAs given in this study (rat).

    Measurements

    Maximal systolic blood pressure difference
    21 mmHg
    male SHR, after last injection

    Source sentences

    Summary
    Blood pressure decreased further in response to each injection and a maximal difference of 21 mmHg (systolic) (p < 0.01), compared to controls, was reached after the last injection.
    1 context sentence
    Summary · context
    For this purpose subcutaneous (s.c.) injections of oxytocin 1 mg/kg or saline were given for 5 days to male and female SHR.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In male spontaneously hypertensive rats, oxytocin had no effect on heart rate compared with saline.

    In plain wordsIn male hypertensive rats, oxytocin did not change heart rate compared with saline.

    Peptide
    Oxytocin
    Outcome
    No significant changeHeart rate in male SHR
    Study

    ratn: not reported in source

    spontaneously hypertensive rats (SHR)
    Comparator
    Saline
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1 mg/kg · subcutaneous · 5 daysAs given in this study (rat).

    Source sentences

    Summary
    In male rats, a significant decrease in blood pressure (systolic; p < 0.01, diastolic; p < 0.05), but no effect on heart rate, was seen the day after the first injection of oxytocin, when compared to saline-treated controls.
    1 context sentence
    Summary · context
    For this purpose subcutaneous (s.c.) injections of oxytocin 1 mg/kg or saline were given for 5 days to male and female SHR.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In male spontaneously hypertensive rats, systolic blood pressure was again significantly lower on day 10 in the oxytocin-treated group.

    In plain wordsIn male hypertensive rats, systolic blood pressure was again lower on day 10 in the oxytocin-treated group.

    Peptide
    Oxytocin
    Outcome
    DecreaseSystolic blood pressure on day 10 in male SHR
    Study

    ratn: not reported in source

    spontaneously hypertensive rats (SHR)
    Comparator
    Saline
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    1 mg/kg · subcutaneous · 5 daysAs given in this study (rat).

    Source sentences

    Summary
    On day 10, the oxytocin-treated SHR males again had a significantly lower systolic blood pressure (p < 0.05).
    1 context sentence
    Summary · context
    For this purpose subcutaneous (s.c.) injections of oxytocin 1 mg/kg or saline were given for 5 days to male and female SHR.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In female spontaneously hypertensive rats, the same oxytocin treatment did not affect blood pressure.

    In plain wordsIn female hypertensive rats, oxytocin did not change blood pressure.

    Peptide
    Oxytocin
    Outcome
    No significant changeBlood pressure in female SHR
    Study

    ratn: not reported in source

    spontaneously hypertensive rats (SHR)
    Comparator
    Saline
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    1 mg/kg · subcutaneous · 5 daysAs given in this study (rat).

    Source sentences

    Summary
    In female SHR, the same treatment with oxytocin affected neither blood pressure nor heart rate.
    1 context sentence
    Summary · context
    For this purpose subcutaneous (s.c.) injections of oxytocin 1 mg/kg or saline were given for 5 days to male and female SHR.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In female spontaneously hypertensive rats, the same oxytocin treatment did not affect heart rate.

    In plain wordsIn female hypertensive rats, oxytocin did not change heart rate.

    Peptide
    Oxytocin
    Outcome
    No significant changeHeart rate in female SHR
    Study

    ratn: not reported in source

    spontaneously hypertensive rats (SHR)
    Comparator
    Saline
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1 mg/kg · subcutaneous · 5 daysAs given in this study (rat).

    Source sentences

    Summary
    In female SHR, the same treatment with oxytocin affected neither blood pressure nor heart rate.
    1 context sentence
    Summary · context
    For this purpose subcutaneous (s.c.) injections of oxytocin 1 mg/kg or saline were given for 5 days to male and female SHR.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In male spontaneously hypertensive rats, the significant blood pressure difference versus saline was gone 3 days after the last oxytocin injection, although a tendency to lower blood pressure persisted.

    In plain wordsIn male hypertensive rats, the blood pressure drop from oxytocin was no longer significant 3 days after the last injection, compared with saline.

    Peptide
    Oxytocin
    Outcome
    No significant changeSystolic blood pressure 3 days after last injection in male SHR
    Study

    ratn: not reported in source

    spontaneously hypertensive rats (SHR)
    Comparator
    Saline
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    1 mg/kg · subcutaneous · 5 daysAs given in this study (rat).

    Source sentences

    Summary
    The significant effect was gone 3 days after the last injection, although a tendency to a lower blood pressure in the oxytocin-treated rats persisted.
    1 context sentence
    Summary · context
    For this purpose subcutaneous (s.c.) injections of oxytocin 1 mg/kg or saline were given for 5 days to male and female SHR.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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