In fetal rat calvaria cells, des(1‑3)-IGF-I enhanced OP-1-induced alkaline phosphatase activity more effectively than full-length IGF-I.
In plain wordsIn cells from rats, des(1‑3)-IGF-I with OP-1 increased alkaline phosphatase activity more than full-length IGF-I with OP-1.
- Peptide
- IGF-1 DES (des(1-3)IGF-I)
- Outcome
- IncreaseOP-1-induced alkaline phosphatase activity
- Study
ratn: not reported in source
Primary fetal rat calvaria cells- Comparator
- Full-length IGF-I with OP-1
- Outcome group
- Bone and joint · Musculoskeletal
Source sentences
Des(1-3)-IGF-I, which has a lower affinity for IGFBPs, was more effective than the full-length IGF-I in enhancing the OP-1-induced alkaline phosphatase activity.
1 context sentence(design, population, supporting numbers)
Previous studies have shown that osteogenic protein-1 (OP-1; also known as BMP-7) alters the steady state levels of messenger RNA (mRNA) encoding insulin-like growth factor I (IGF-I), IGF-II, and IGF-binding proteins (IGFBPs) in primary cultures of fetal rat calvaria (FRC) cells.
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).