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Study · In vitro (cells) · bovine · 1997

4 results

Interactions between follicle-stimulating hormone and growth factors in regulation of deoxyribonucleic acid synthesis in bovine granulosa cells.

Khamsi F, Armstrong DT

Biology of reproduction1 Sept 1997Cited by 23 (Europe PMC)

PMID9283008 (opens in a new tab)DOI10.1095/biolreprod57.3.684 (opens in a new tab)PepBankPUB-09283008
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In bovine cumulus cells, LR3-IGF-I stimulated [3H]thymidine incorporation, to a much greater extent than in mural granulosa cells.

    In plain wordsIn cow cumulus cells, LR3-IGF-I increased DNA synthesis, much more than in mural granulosa cells.

    Peptide
    IGF-1 LR3
    Outcome
    Increase[3H]thymidine incorporation in cumulus cells
    Study

    bovinen: not reported in source

    bovine granulosa cells (cumulus and mural)
    Outcome group
    Cell proliferation and differentiation · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both IGF-I and LR3-IGF-I stimulated [3H]thymidine incorporation in cumulus cells to a much greater extent than in mural granulosa cells.
    1 context sentence
    Summary · context
    To determine the possible role of IGFBP in modulating the mitogenic response to IGF-I, an IGF-I analogue that does not bind to IGFBP, long arg3-IGF-I (LR3-IGF-I), was compared with native IGF-I for efficacy in stimulating DNA synthesis in the absence and presence of each of the above agonists.
  2. 02LabIn vitro (cells)Mechanism

    In bovine mural granulosa cells, LR3-IGF-I stimulated [3H]thymidine incorporation, but to a smaller extent than in cumulus cells.

    In plain wordsIn cow mural granulosa cells, LR3-IGF-I increased DNA synthesis, but less than in cumulus cells.

    Peptide
    IGF-1 LR3
    Outcome
    Increase[3H]thymidine incorporation in mural granulosa cells
    Study

    bovinen: not reported in source

    bovine granulosa cells (cumulus and mural)
    Outcome group
    Cell proliferation and differentiation · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both IGF-I and LR3-IGF-I stimulated [3H]thymidine incorporation in cumulus cells to a much greater extent than in mural granulosa cells.
    1 context sentence
    Summary · context
    To determine the possible role of IGFBP in modulating the mitogenic response to IGF-I, an IGF-I analogue that does not bind to IGFBP, long arg3-IGF-I (LR3-IGF-I), was compared with native IGF-I for efficacy in stimulating DNA synthesis in the absence and presence of each of the above agonists.

Studies that did not test the peptide alone2

In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 LR3.

  1. 03LabNot a test of IGF-1 LR3 aloneIn vitro (cells)Mechanism

    In bovine mural granulosa cells, DNA synthesis was considerably enhanced in most instances by FSH, EGF or dbcAMP combined with each IGF-I form, including LR3-IGF-I.

    In plain wordsIn cow mural cells, adding FSH, EGF or dbcAMP to the IGF-I forms often raised DNA synthesis further.

    Peptide
    IGF-1 LR3
    Outcome
    Increase[3H]thymidine incorporation in mural cells with FSH, EGF or dbcAMP plus IGF-I forms
    Study

    bovinen: not reported in source

    bovine granulosa cells (cumulus and mural)
    Outcome group
    Cell proliferation and differentiation · Reproductive and sexual health

    Source sentences

    Summary
    Incorporation in mural cells was increased by each of FSH, EGF, and dbcAMP acting by itself, and in most instances was considerably enhanced by the combined action of these agents with each of the IGF-I forms.
    1 context sentence
    Summary · context
    To determine the possible role of IGFBP in modulating the mitogenic response to IGF-I, an IGF-I analogue that does not bind to IGFBP, long arg3-IGF-I (LR3-IGF-I), was compared with native IGF-I for efficacy in stimulating DNA synthesis in the absence and presence of each of the above agonists.

    In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.

  2. 04LabNot a test of IGF-1 LR3 aloneIn vitro (cells)Mechanism

    In bovine cumulus cells, the stimulatory effect of IGF-I and LR3-IGF-I was markedly decreased by FSH, EGF and dbcAMP.

    In plain wordsIn cow cumulus cells, FSH, EGF and dbcAMP strongly reduced the DNA synthesis that IGF-I and LR3-IGF-I had caused.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseStimulation of cumulus cells by IGF-I forms with FSH, EGF or dbcAMP
    Study

    bovinen: not reported in source

    bovine granulosa cells (cumulus and mural)
    Outcome group
    Cell proliferation and differentiation · Reproductive and sexual health

    Source sentences

    Summary
    In contrast, the considerably greater stimulatory effect of both IGF-I and LR3-IGF-I on cumulus cells was markedly decreased by each of FSH, EGF, and dbcAMP.
    1 context sentence
    Summary · context
    To determine the possible role of IGFBP in modulating the mitogenic response to IGF-I, an IGF-I analogue that does not bind to IGFBP, long arg3-IGF-I (LR3-IGF-I), was compared with native IGF-I for efficacy in stimulating DNA synthesis in the absence and presence of each of the above agonists.

    In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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